Results 41 to 50 of about 122,423 (305)

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

, 2011
Background: The ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN) and neurons of the red nucleus (RN).
Joyner, Alexandra L., Stephen Daniel, Chanet, S., Chanet, Soline, Blaess, S., Emilie Mugniery, Sandra Blaess, Joyner, L., Daniel Stephen, Soline Chanet, Mugniery, E., Kabanova, Anna, Bodea, G., Blaess, Sandra, Derouiche, Amin, Alexandra L Joyner, Mugniery Emilie, Gabriela O Bodea, Chanet Soline, Joyner, Alexandra, Joyner Alexandra L, Bodea, Gabriela O., Mugniery, Emilie, Derouiche, A., Blaess Sandra, Stephen, D., Kabanova, A., Derouiche Amin, Bodea Gabriela O, Bodea, Gabriela, Kabanova Anna, Anna Kabanova, Stephen, Daniel, Amin Derouiche   +33 more
core   +2 more sources

Direct Glutamatergic Signaling From Midbrain Dopaminergic Neurons Onto Pyramidal Prefrontal Cortex Neurons

Frontiers in Neural Circuits, 2018
The dopaminergic neurons of the ventral tegmental area (VTA) have been identified with the ability to co-release dopamine and glutamate. This ability was first documented in the nucleus accumbens but showed to be absent in the dorsal striatum.
José Luis Pérez-López, Rubén Contreras-López, Josué O. Ramírez-Jarquín, Fatuel Tecuapetla   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

NOX4 exacerbates Parkinson’s disease pathology by promoting neuronal ferroptosis and neuroinflammation

Neural Regeneration Research
Parkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a vital role in the death of ...
Zhihao Lin, Changzhou Ying, Xiaoli Si, Naijia Xue, Yi Liu, Ran Zheng, Ying Chen, Jiali Pu, Baorong Zhang   +8 more
doaj   +1 more source

Growth factors and feeder cells promote differentiation of human embryonic stem cell into dopaminergic neurons: a novel role of fibroblast growth factor-20

Frontiers in Neuroscience, 2008
Human embryonic stem cells (hESCs) are a potential source of dopaminergic neurons for treatment of Parkinson’s disease (PD). Dopaminergic neurons can be derived from hESCs and display a characteristic midbrain phenotype. Once transplanted, they can
Ana Sofia Correia, Jia-Yi Li, Patrik Brundin   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

, 2017
Exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (SN) and may in fact initiate the loss of dopaminergic neurons within the SN.
Ong, Lin Kooi, Zalewska, Katarzyna, Zhao, Zidan, Dickson, Phillip W., Walker, Frederick R., TeBay, Clifford, Nilsson, Michael, Kluge, Murielle, Johnson, Sarah J.   +8 more
core   +1 more source

Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. [PDF]

PLoS ONE, 2009
BACKGROUND:Human embryonic stem cells (hESCs) may provide an invaluable resource for regenerative medicine. To move hESCs towards the clinic it is important that cells with therapeutic potential be reproducibly generated under completely defined ...
Andrzej Swistowski, Jun Peng, Yi Han, Anna Maria Swistowska, Mahendra S Rao, Xianmin Zeng   +5 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Spontaneous Activity of Dopaminergic Retinal Neurons [PDF]

Biophysical Journal, 2003
Dopaminergic local circuit neurons in the retina (DA cells) show robust, spontaneous, tetrodotoxin-sensitive pacemaking. To investigate the mechanism underlying this behavior, we characterized the sodium current and a subset of the potassium currents in the cells in voltage-clamp experiments.
Steffen, Michael A., Seay, Christina A., Amini, Behrang, Cai, Yidao, Feigenspan, Andreas, Baxter, Douglas A., Marshak, David W.   +6 more
openaire   +2 more sources