Results 51 to 60 of about 122,423 (305)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Investigations into the use of human embryonal carcinoma stem cells as a model to study dopaminergic neurogenesis [PDF]

, 2009
Parkinson's disease in reality arises as a result of a complex series of events, however it is strongly linked to the loss of a specific cellular population of midbrain dopaminergic neurons making it a candidate for stem cell based research.
Bramwell, Thomas William
core  

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

Neurobiology of Disease, 2014
Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells.
Jun-Shiao Chou, Chu-Yu Chen, Ying-Ling Chen, Yi-Hsin Weng, Tu-Hsueh Yeh, Chin-Song Lu, Ya-Ming Chang, Hung-Li Wang   +7 more
doaj   +1 more source

Arecoline Induces an Excitatory Response in Ventral Tegmental Area Dopaminergic Neurons in Anesthetized Rats

Frontiers in Pharmacology, 2022
Arecoline is the principle psychoactive alkaloid in areca nuts. Areca nuts are chewable seeds of Areca catechu L., which are epidemic plants that grow in tropical and subtropical countries and cause dependency after long-term use. However, the mechanisms
Qinghui Lan, Peiqing Guan, Chunzheng Huang, Shile Huang, Peiling Zhou, Changzheng Zhang   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons

Biology
Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain.
Valentina Basso, Máté D. Döbrössy, Lachlan H. Thompson, Deniz Kirik, Heidi R. Fuller, Monte A. Gates   +5 more
doaj   +1 more source

Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats

Frontiers in Neuroanatomy, 2020
Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim of this study was to investigate
Slobodan Kapor, Milan Aksić, Laslo Puškaš, Marin Jukić, Marin Jukić, Joko Poleksić, Filip Milosavljević, Suncica Bjelica, Suncica Bjelica, Branislav Filipović   +9 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Functional Analyses of dopaminergic neurons.

, 2013
Standard whole-cell patch clamp, current-clamp techniques (A) and dopamine release measurement (B) were performed to explore the biological function of dopaminergic neurons.
Huixia Ren (500186), Yaohua Hu (500185), Chuanming Luo (500187), Na Ni (500184), Peng Li (69518), Jian-Bo Wan (500188), Huanxing Su (104291)   +6 more
core   +1 more source

Stimulation of Dopamine Production by Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive

Journal of Alzheimer's Disease Reports, 2021
Background: Parkinson’s disease (PD) is one of the most important neurodegenerative disorders in human in which recovery of functions could be achieved by improving the survival and function of residual dopaminergic neurons in the substantia nigra pars ...
Suresh B. Rangasamy, Sridevi Dasarathi, Aparna Nutakki, Shreya Mukherjee, Rohith Nellivalasa, Kalipada Pahan   +5 more
doaj   +1 more source