Illicit Stimulant Use Is Associated with Abnormal Substantia Nigra Morphology in Humans [PDF]
PLoS ONE, 2013 Use of illicit stimulants such as methamphetamine, cocaine, and ecstasy is an increasing health problem. Chronic use can cause neurotoxicity in animals and humans but the long-term consequences are not well understood. The aim of the current study was to
Gabrielle Todd +2 more
exaly +3 more sources
Super-resolution ultrasound imaging indirectly reveals neurovascular uncoupling in substantia nigra of a Parkinson’s disease model [PDF]
npj Parkinson's DiseaseNeurovascular coupling contributes to the regulation of cognitive function in Parkinson’s disease (PD). However, the correlation between structural and functional integrity of neurovascular unit in substantia nigra and cognitive impairment in PD remains ...
Chao Hou +7 more
doaj +2 more sources
9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease [PDF]
NeuroImage: Clinical, 2017 Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey +12 more
doaj +2 more sources
Semi-Automated Neuromelanin-Sensitive MRI Reveals Substantia Nigra Volume Reduction in Early Parkinson’s Disease with Moderate Diagnostic Performance [PDF]
DiagnosticsBackground: Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, accompanied by neuromelanin loss.
Arturs Silovs +14 more
doaj +2 more sources
Stable Dopamine-Signaling mRNA Co-Expression in the Substantia Nigra Is Deregulated in Pathological Conditions, but Not in Dopamine Transporter Knockout Rats [PDF]
BiomoleculesDopamine transporter (DAT) mutations are associated with neurological and psychiatric diseases, and DAT gene knockout in rats (DAT-KO) provides an opportunity to evaluate the DAT role in pathological conditions.
Anastasia N. Vaganova +3 more
doaj +2 more sources
Frontiers in Neurology, 2023 ObjectiveThis study aimed to investigate the application value of multi-parametric magnetic resonance imaging (MRI) in the diagnosis of iron deposition in the substantia nigra dense zone in Parkinson's disease (PD) and to evaluate the diagnostic value of
Qing Cao +7 more
doaj +1 more source
PLoS ONE, 2023 Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang +4 more
doaj +3 more sources
THE SUBSTANTIA NIGRA SOEMERINGI [PDF]
The Journal OF Nervous and Mental Disease, 1909 n ...
Bauer, Julius, Karpas, M. J.
openaire +1 more source
Crystals in the Substantia Nigra [PDF]
ACS Chemical Neuroscience, 2019 Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
openaire +2 more sources
Measurement of the adult human midbrain with transcranial ultrasound.
PLoS ONE, 2021 BackgroundTranscranial sonography is increasingly used to aid clinical diagnoses of movement disorders, for example, to identify an enlarged area of substantia nigra echogenicity in patients with Parkinson's disease.ObjectiveThe current study ...
Karl Aoun +5 more
doaj +1 more source