Results 11 to 20 of about 86,799 (302)

Histological changes in the substantia nigra in Parkinsonism model in male albino rat [PDF]

Minia Journal of Medical Research, 2019
The substantia nigra is a part of the basal ganglia that is present in the midbrain. It is characterized by the presence of dopaminergic neurons in the substantia nigra pars compacta.Parkinsonism disease is one of the most common neurodegenerative ...
Sara Abdel-Hafez, Manar Ibrahim, , Sara Elsebaay, Soha Abdelwahab   +3 more
doaj   +1 more source

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease [PDF]

, 2021
Parkinson’s disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Parkinson’
Hans Rudolf Widmer, Lukas Andereggen, Widmer, Hans Rudolf, Andereggen, L., Widmer, H.R., Hewer, E., Andereggen, Lukas, Seiler, Stefanie, Seiler, S., Ekkehard Hewer, Stefanie Seiler, Di Santo, S., Gian-Carlo Eyer, Di Santo, Stefano, Hewer, Ekkehard, Eyer, Gian-Carlo, Eyer, G.C., Stefano Di Santo   +17 more
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Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20 [PDF]

, 2021
Background Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) underlines much of the pathology of Parkinson’s disease (PD), but the existence of an endogenous neurogenic system that could be targeted as a therapeutic strategy has ...
Danai Kassandra Meri, Ilias Kazanis, Maria Anesti, Dimitrios Dimitrakopoulos, Konstantinos Botsakis, Ioannis Charalampopoulos, Dimitrios Kakogiannis, Theodora Mourtzi, Achilleas Gravanis, Fevronia Angelatou, Nikolaos Matsokis, Charalampos Salodimitris, Aggeliki Dimopoulou   +12 more
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MRI T2 and T2* relaxometry to visualize neuromelanin in the dorsal substantia nigra pars compacta

NeuroImage, 2020
Visualizing gradual changes in neuromelanin distribution within the substantia nigra is an important metric used to monitor the progression of Parkinsonism.
Hansol Lee, Sun-Yong Baek, Eun-Joo Kim, Gi Yeong Huh, Jae-Hyeok Lee, HyungJoon Cho   +5 more
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Neuromelanin Imaging and Dopaminergic Loss in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra.
Ioannis Ugo Isaias, Ioannis Ugo Isaias, Paula Trujillo, Paula Trujillo, Paul Summers, Giorgio Marotta, Luca Mainardi, Gianni Pezzoli, Luigi Zecca, Antonella Costa   +9 more
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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Nature Communications, 2020
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber   +8 more
doaj   +1 more source

Korrelate von Substantia Nigra Echogenität bei gesunden Kindern

, 2021
Objective: Substantia nigra hyperechogenicity is found in children with attention- deficit hyperactivity disorder (ADHD). Research with transcranial sonography (TCS) in adults suggests that echogenic alterations are linked to subclinical behavioral ...
Schaeff, Sulamith
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Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2022
ObjectivesBrain iron deposition and microstructural changes in brain tissue are associated with Parkinson’s disease (PD). However, the correlation between these factors in Parkinson’s disease has been little studied.
Lin Yang, Lin Yang, Yan Cheng, Yongyan Sun, Yinghua Xuan, Jianping Niu, Jitian Guan, Yunjie Rong, Yanlong Jia, Zerui Zhuang, Gen Yan, Renhua Wu, Renhua Wu   +12 more
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Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]

, 2007
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu, Edgar R Kramer, Zhuang, Xiaoxi, Zhuang, X. X., Klein, R., Klaus Beyer, Geert M J Ramakers, Smidt, M. P., Smidt, Marten P., Kramer, E., Ramakers, Geert M. J., Klein, Rüdiger, Beyer, K., Seitz, S., Marten P Smidt, Ramakers, G., Xiaoxi Zhuang, Beyer, Klaus, Zhuang, X., Liviu Aron, Sabine Seitz, Rüdiger Klein, Smidt, M., Seitz, Sabine, Kramer, Edgar R., Aron, L., Ramakers, G. M. J., Kramer, E. R.   +27 more
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A robust method for the detection of small changes in relaxation parameters and free water content in the vicinity of the substantia nigra in Parkinson's disease patients.

PLoS ONE, 2021
Alterations in the substantia nigra are strongly associated with Parkinson's disease. However, due to low contrast and partial volume effects present in typical MRI images, the substantia nigra is not of sufficient size to obtain a reliable segmentation ...
Krzysztof Dzieciol, Elene Iordanishvili, Zaheer Abbas, Adjmal Nahimi, Michael Winterdahl, N Jon Shah   +5 more
doaj   +1 more source