Illicit Stimulant Use Is Associated with Abnormal Substantia Nigra Morphology in Humans [PDF]
PLoS ONE, 2013 Use of illicit stimulants such as methamphetamine, cocaine, and ecstasy is an increasing health problem. Chronic use can cause neurotoxicity in animals and humans but the long-term consequences are not well understood. The aim of the current study was to
Gabrielle Todd +2 more
exaly +2 more sources
Semi-Automated Neuromelanin-Sensitive MRI Reveals Substantia Nigra Volume Reduction in Early Parkinson’s Disease with Moderate Diagnostic Performance [PDF]
DiagnosticsBackground: Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, accompanied by neuromelanin loss.
Arturs Silovs +14 more
doaj +2 more sources
Stable Dopamine-Signaling mRNA Co-Expression in the Substantia Nigra Is Deregulated in Pathological Conditions, but Not in Dopamine Transporter Knockout Rats [PDF]
BiomoleculesDopamine transporter (DAT) mutations are associated with neurological and psychiatric diseases, and DAT gene knockout in rats (DAT-KO) provides an opportunity to evaluate the DAT role in pathological conditions.
Anastasia N. Vaganova +3 more
doaj +2 more sources
Frontiers in Neurology, 2023 ObjectiveThis study aimed to investigate the application value of multi-parametric magnetic resonance imaging (MRI) in the diagnosis of iron deposition in the substantia nigra dense zone in Parkinson's disease (PD) and to evaluate the diagnostic value of
Qing Cao +7 more
doaj +1 more source
PLoS ONE, 2023 Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang +4 more
doaj +3 more sources
Wfs1 Is Expressed In Dopaminoceptive Regions Of The Amniote Brain And Modulates Levels Of D1-Like Receptors [PDF]
, 2017 During amniote evolution, the construction of the forebrain has diverged across different lineages, and accompanying the structural changes, functional diversification of the homologous brain regions has occurred.
Allikalt, A. +13 more
core +15 more sources
Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue [PDF]
, 2020 Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens.
Griesser, Eva +5 more
core +3 more sources
Crystals in the Substantia Nigra [PDF]
ACS Chemical Neuroscience, 2019 Crystals of TiO2 and CaO were detected in electron-beam exposed extracts of four substantia nigra specimens of Parkinson's disease donors. A likely precursor of the CaO crystals is inflammatory calcium oxalate dihydrate, decomposing according to CaC2O4·2H2O → CaO + CO↑ + CO2↑ + 2H2O↑.
Adam Heller, Sheryl S. Coffman
openaire +2 more sources
Measurement of the adult human midbrain with transcranial ultrasound.
PLoS ONE, 2021 BackgroundTranscranial sonography is increasingly used to aid clinical diagnoses of movement disorders, for example, to identify an enlarged area of substantia nigra echogenicity in patients with Parkinson's disease.ObjectiveThe current study ...
Karl Aoun +5 more
doaj +1 more source
THE SUBSTANTIA NIGRA SOEMERINGI [PDF]
The Journal OF Nervous and Mental Disease, 1909 n ...
Bauer, Julius, Karpas, M. J.
openaire +1 more source