Results 11 to 20 of about 73,544 (253)

Neuromelanin Imaging and Dopaminergic Loss in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder in which the major pathologic substrate is a loss of dopaminergic neurons from the substantia nigra.
Ioannis Ugo Isaias, Ioannis Ugo Isaias, Paula Trujillo, Paula Trujillo, Paul Summers, Giorgio Marotta, Luca Mainardi, Gianni Pezzoli, Luigi Zecca, Antonella Costa   +9 more
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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

Nature Communications, 2020
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber   +8 more
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9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease

NeuroImage: Clinical, 2017
Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey, MA Miranda, O Al-Helli, HG Parkes, JS Thornton, P-W So, MJ White, L Mancini, C Strand, J Holton, AJ Lees, T Revesz, TA Yousry   +12 more
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Combined Application of Quantitative Susceptibility Mapping and Diffusion Kurtosis Imaging Techniques to Investigate the Effect of Iron Deposition on Microstructural Changes in the Brain in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2022
ObjectivesBrain iron deposition and microstructural changes in brain tissue are associated with Parkinson’s disease (PD). However, the correlation between these factors in Parkinson’s disease has been little studied.
Lin Yang, Lin Yang, Yan Cheng, Yongyan Sun, Yinghua Xuan, Jianping Niu, Jitian Guan, Yunjie Rong, Yanlong Jia, Zerui Zhuang, Gen Yan, Renhua Wu, Renhua Wu   +12 more
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A robust method for the detection of small changes in relaxation parameters and free water content in the vicinity of the substantia nigra in Parkinson's disease patients.

PLoS ONE, 2021
Alterations in the substantia nigra are strongly associated with Parkinson's disease. However, due to low contrast and partial volume effects present in typical MRI images, the substantia nigra is not of sufficient size to obtain a reliable segmentation ...
Krzysztof Dzieciol, Elene Iordanishvili, Zaheer Abbas, Adjmal Nahimi, Michael Winterdahl, N Jon Shah   +5 more
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Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

Neurobiology of Disease, 2015
Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting.
Junchao Tong, Lee-Cyn Ang, Belinda Williams, Yoshiaki Furukawa, Paul Fitzmaurice, Mark Guttman, Isabelle Boileau, Oleh Hornykiewicz, Stephen J. Kish   +8 more
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Striatal Infarction in the Rat Causes a Transient Reduction of Tyrosine Hydroxylase Immunoreactivity in the Ipsilateral Substantia Nigra

Neurobiology of Disease, 1997
Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia.
Marc A. Soriano, Carles Justicia, Isidre Ferrer, Eduard Rodrı́guez-Farré, Anna M. Planas   +4 more
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Microstructural changes within the basal ganglia differ between Parkinson disease subtypes

Frontiers in Neuroanatomy, 2016
Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae, Justin M Honce, Jody eTanabe, Erika eShelton, Stefan H Sillau, Brian D Berman, Brian D Berman   +6 more
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Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses

Frontiers in Aging Neuroscience
BackgroundParkinson’s disease (PD) is a complex, common neurodegenerative disorder with unclear etiology. The pathogenic hallmark is the death of dopaminergic neurons in the substantia nigra. PD diagnosis depends on clinical manifestation of symptoms but
Hui-Hui Fan, Na-Na Hou, Na-Na Hou, Dao-Lu Zhang, Dan-Ni Liu, Rong-Ting Tang, Hai-Tao Luo, Ya-Dan Song, Lei Cui, Xiong Zhang, Jian-Hong Zhu, Jian-Hong Zhu   +11 more
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Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease

Frontiers in Neuroscience, 2017
The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients.
Chunmei Li, Min Chen, Xuna Zhao, Rui Wang, Haibo Chen, Wen Su, Shuhua Li, Baohui Lou, Guodong Song, Shuai Zhang, Jintao Zhang, Jinyuan Zhou   +11 more
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