Results 21 to 30 of about 86,799 (302)

Dopamine restores reward prediction errors in old age [PDF]

, 2013
Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value ...
Dayan, P., Dolan, Raymond J, Dayan, P, Dolan, R., Huys, Q., Guitart-Masip, M. ; https://orcid.org/, Düzel, E., Rumana Chowdhury, Chowdhury, R., Christian Lambert, Emrah Düzel, Duezel, Emrah, Guitart-Masip, M., Dolan, Raymond J., Lambert, C., Lambert, C, Chowdhury, Rumana, Chowdhury, R, Guitart-Masip, Marc,, Guitart-Masip, Marc, Dolan, RJ, Marc Guitart-masip, Düzel, E, Dolan, R. ; https://orcid.org/, Raymond J Dolan, Peter Dayan, Dayan, Peter, Guitart-Masip, M, Düzel, Emrah, Huys, Q, Lambert, Christian, Quentin Huys, Huys, Quentin   +32 more
core   +1 more source

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

Neurobiology of Disease, 2015
Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting.
Junchao Tong, Lee-Cyn Ang, Belinda Williams, Yoshiaki Furukawa, Paul Fitzmaurice, Mark Guttman, Isabelle Boileau, Oleh Hornykiewicz, Stephen J. Kish   +8 more
doaj   +1 more source

Striatal Infarction in the Rat Causes a Transient Reduction of Tyrosine Hydroxylase Immunoreactivity in the Ipsilateral Substantia Nigra

Neurobiology of Disease, 1997
Dopaminergic neurons of the substantia nigra pars compacta were examined in the rat brain following striatal infarction subsequent to transient focal cerebral ischemia.
Marc A. Soriano, Carles Justicia, Isidre Ferrer, Eduard Rodrı́guez-Farré, Anna M. Planas   +4 more
doaj   +1 more source

Microstructural changes within the basal ganglia differ between Parkinson disease subtypes

Frontiers in Neuroanatomy, 2016
Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia ...
Lidia M Nagae, Justin M Honce, Jody eTanabe, Erika eShelton, Stefan H Sillau, Brian D Berman, Brian D Berman   +6 more
doaj   +1 more source

Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses

Frontiers in Aging Neuroscience
BackgroundParkinson’s disease (PD) is a complex, common neurodegenerative disorder with unclear etiology. The pathogenic hallmark is the death of dopaminergic neurons in the substantia nigra. PD diagnosis depends on clinical manifestation of symptoms but
Hui-Hui Fan, Na-Na Hou, Na-Na Hou, Dao-Lu Zhang, Dan-Ni Liu, Rong-Ting Tang, Hai-Tao Luo, Ya-Dan Song, Lei Cui, Xiong Zhang, Jian-Hong Zhu, Jian-Hong Zhu   +11 more
doaj   +1 more source

The neurotoxicity of DOPAL: behavioral and stereological evidence for its role in Parkinson disease pathogenesis. [PDF]

PLoS ONE, 2010
BACKGROUND: The etiology of Parkinson disease (PD) has yet to be fully elucidated. We examined the consequences of injections of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a toxic metabolite of dopamine, into the substantia nigra of rats on motor behavior ...
W Michael Panneton, V B Kumar, Qi Gan, William J Burke, James E Galvin   +4 more
doaj   +1 more source

Iron deficiency in parkinsonism : region-specific iron dysregulation in Parkinson's disease and multiple system atrophy [PDF]

Alpha synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution is unknown.
Visanji, Naomi P., Finnegan, Mary E., Collingwood, Joanna F., Hazrati, Lili-Naz, Tandon, Anurag, House, Emily   +5 more
core   +1 more source

Chemical Exchange Saturation Transfer MRI Signal Loss of the Substantia Nigra as an Imaging Biomarker to Evaluate the Diagnosis and Severity of Parkinson's Disease

Frontiers in Neuroscience, 2017
The early diagnosis of Parkinson's disease (PD) and the accurate evaluation of disease severity are crucial for intervention and treatment in PD patients.
Chunmei Li, Min Chen, Xuna Zhao, Rui Wang, Haibo Chen, Wen Su, Shuhua Li, Baohui Lou, Guodong Song, Shuai Zhang, Jintao Zhang, Jinyuan Zhou   +11 more
doaj   +1 more source

Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra

, 2021
Inflammation plays a role in neuropathology. We hypothesised that inflammation, induced by a single intraperitoneal injection of lipopolysaccharide (LPS), would induce long-term changes in the regulation of tyrosine hydroxylase (TH) in the rat midbrain ...
Ong, Lin Kooi, Dickson, Phillip W., Guan, Liying, Dunkley, Peter R., Briggs, Gabrielle D.   +4 more
core   +1 more source

Eyes as Gateways for Environmental Light to the Substantia Nigra: Relevance in Parkinson’s Disease

The Scientific World Journal, 2014
Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra
Stefania Romeo, Daniela Di Camillo, Alessandra Splendiani, Marta Capannolo, Cristina Rocchi, Gabriella Aloisi, Irene Fasciani, Giovanni U. Corsini, Eugenio Scarnati, Luca Lozzi, Roberto Maggio   +10 more
doaj   +1 more source