Results 1 to 10 of about 108,344 (304)

Production of gamma-aminobutyric acid by Lactobacillus brevis NCL912 using fed-batch fermentation [PDF]

Microbial Cell Factories, 2010
Background Gamma-aminobutyric acid is a major inhibitory neurotransmitter in mammalian brains, and has several well-known physiological functions. Lactic acid bacteria possess special physiological activities and are generally regarded as safe. Therefore,
Huang Guidong, Qiu Ting, Li Haixing, Cao Yusheng   +3 more
doaj   +3 more sources

Urine amino acid and gamma aminobutyric acid level in COVID 19 patients [PDF]

Iranian Journal of Microbiology
Background and Objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most ...
Cemal Kazezoglu, Arzu İrvem, Yasemin Tuba Sutasir, Büşra Çakiroglu, Banu Kirgiz, Habip Yilmaz, Ali Kocatas   +6 more
doaj   +1 more source

Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling [PDF]

Cancer & Metabolism
Objective Cancer cells exhibit abnormal dependence on glutamine, which is associated with the hyperactivation of γ-aminobutyric acid (GABA) metabolic pathways that promotes tumor growth.
Jing Dong, Yuanyuan Wu, Ji Che, Zhiyong He, Jun Zhang   +4 more
doaj   +2 more sources

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration [PDF]

, 2012
Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in ...
A Agrawal, A Pierucci-Lagha, A Ruiz, AR Yang, C Fahlke, C Schwarzer, CI Dixon, CI Dixon, Claire I. Dixon, D Belelli, David N. Stephens, DM Dick, E Persohn, GJ Lydall, HH Samson, HJ Edenberg, HL June, HM Haughey, HV Morris, HV Morris, I Ponomarev, J Covault, J Lappalainen, JE Kralic, JE Kralic, JL Weiner, JT Sakai, K Low, KA Wafford, M Roberto, M Tauber, M Wakita, MA Enoch, MA Enoch, ML Barbaccia, N Onori, PA Lind, PJ Zhu, RT Khisti, Rudolph Uwe, S Bohlhalter, S Hansen, S Pirker, S Ueno, Sarah L. King, Sophie E. Walker, YA Blednov   +46 more
core   +10 more sources

GABA transaminase deficiency. Case report and literature review

Clinical Case Reports, 2021
GABA transaminase deficiency should be considered in the differential diagnosis of early onset epileptic encephalopathies. This case was diagnosed post‐mortem, but increased vigilance to this will allow for earlier diagnoses in other infants and families.
Amira Oshi, Abdullah Alfaifi, Mohammed Z. Seidahmed, Khalid Al Hussein, Abeer Miqdad, Abdelmohsin Samadi, Omar Abdelbasit   +6 more
doaj   +1 more source

Sleep deprivation: a risk for epileptic seizures [PDF]

Sleep Science, 2022
There is a well-documented correlation between epilepsy and sleep deprivation. For decades, preclinical and clinical studies have shown that sleep deprivation can lead to an increased risk of epileptic seizures.
Jason Tyler Dell’Aquila, Varun Soti
doaj   +1 more source

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source

Anterior cingulate gamma‐aminobutyric acid concentrations and electroconvulsive therapy

Brain and Behavior, 2020
Objective The anticonvulsant hypothesis posits that ECT’s mechanism of action is related to enhancement of endogenous anticonvulsant brain mechanisms. Results of prior studies investigating the role of the inhibitory neurotransmitter gamma‐aminobutyric ...
Vera J. Erchinger, Jeremy Miller, Thomas Jones, Ute Kessler, Juan Bustillo, Jan Haavik, Jonathan Petrillo, Gregory Ziomek, Åsa Hammar, Ketil J. Oedegaard, Vince D. Calhoun, Shawn M. McClintock, Lars Ersland, Leif Oltedal, Christopher C. Abbott   +14 more
doaj   +1 more source

Optimization of Gamma-Aminobutyric Acid Production in Probiotics Extracted from Local Dairy Products in West Region of Iran using MRS broth and Whey Protein Media

Applied Food Biotechnology, 2018
Background and objective: Gamma-aminobutyric acid is a non-protein amino acid produced by lactic acid bacteria in fermented foods and includes unique functions in the human biological system.
Fatemeh Zarei, Leila Nateghi, Mohamad Reza Eshaghi, Maryam Ebrahimi Taj Abadi   +3 more
doaj   +1 more source

Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]

, 2003
The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Calandra, Ricardo S., Doepner, Richard F. G., Frungieri, Monica B., Gamel-Didelon, Katia, Geigerseder, Christof, Kohn, Frank M., Mayerhofer, Artur, Thalhammer, Andrea   +7 more
core   +2 more sources