Results 21 to 30 of about 69,874 (309)

DETERMINATION OF GAMMA - AMINOBUTYRIC ACID BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY [PDF]

Acta Medica Iranica, 1998
Gamma-aminobutyric acid is the main inhibitory amino acid neurotransmitter in several areas of the brain. Measurement of gamma-aminobutyric acid in the brain will help elucidate its metabolic rote and diagnostic value.
D. Qujeq
doaj   +2 more sources

Pharmacokinetic and pharmacodynamic effects of Withania somnifera (L.) Dunal (ashwagandha) and carbamazepine combination in rats [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Withania somnifera, also known as ashwagandha, has antibacterial, anti-inflammatory, anticonvulsant, and anti-diabetic properties and reduces stress. Carbamazepine is one of the most used antiepileptic medications for treating epilepsy. Aims:
Zein Husam Alsabaa, Luay Abu-Qatouseh, Kenza Mansoor, Feras Darwish El-Hajji, Razan Bardees, Ghofran Aljabr, Khaled W. Omari, Eyad Mallah   +7 more
doaj   +1 more source

Temperature dependence of the microwave dielectric properties of $$\gamma$$ γ -aminobutyric acid

Scientific Reports, 2021
The GABA molecule is the major inhibitory neurotransmitter in the mammalian central nervous system. Through binding to post-synaptic neurons, GABA reduces the neuronal excitability by hyperpolarization.
Jie Hou, Sisay Mebre Abie, Runar Strand-Amundsen, Yuri M. Galperin, Joakim Bergli, Christin Schuelke, Sina Hashemizadeh, Ørjan Grøttem Martinsen   +7 more
doaj   +1 more source

Midazolam: an essential palliative care drug

Palliative Care and Social Practice, 2020
Midazolam is a commonly used benzodiazepine in palliative care and is considered one of the four essential drugs needed for the promotion of quality care in dying patients.
Eric Prommer
doaj   +1 more source

The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: A critical reappraisal

International Journal of Preventive Medicine, 2021
Background: Diabetes mellitus (DM) is an endocrine disorder characterized by hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS) of humans and other mammals.
Hayder M Al-Kuraishy, Nawar R Hussian, Marwa S Al-Naimi, Ali I Al-Gareeb, Farah Al-Mamorri, Ali K Al-Buhadily   +5 more
doaj   +1 more source

Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites

Angewandte Chemie, EarlyView.
We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan, Andrew J. Tague, Ashna A. Kumar, Marie Ranson, Christopher J. T. Hyland, Shane R. Ellis   +5 more
wiley   +2 more sources

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Restoration of gamma-aminobutyric acid homeostasis: A novel approach to alleviating central nervous system injury–associated immunodepression syndrome

Neural Regeneration Research
Injuries to the central nervous system can disrupt body functions and often cause excessive sympathetic activity, leading to immune suppression known as central nervous system injury–associated immunodepression syndrome.
Ping Yang, Di Tian, Zijiao Li, Zhongxiang Yao   +3 more
doaj   +1 more source

Chronic myocardial infarction changed the excitatory–inhibitory synaptic balance in the medial prefrontal cortex of rat

Molecular Pain, 2018
The medial prefrontal cortex is a key area for the regulation of pain and emotion. However, the functional involvement of the medial prefrontal cortex for visceral nociception, at the neuronal or synaptic level, is obscure yet.
Jing Li
doaj   +1 more source

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

Cell Reports, 2018
Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation ...
Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Ji Li, Takayuki Wakasugi, Yasuhiko Minokoshi, Shiki Okamoto, Eiichi Hinoi, Søren Nielsen, Naja Zenius Jespersen, Camilla Scheele, Tomoyoshi Soga, Tohru Minamino   +16 more
doaj   +1 more source