Results 21 to 30 of about 66,550 (299)

The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: A critical reappraisal

International Journal of Preventive Medicine, 2021
Background: Diabetes mellitus (DM) is an endocrine disorder characterized by hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS) of humans and other mammals.
Hayder M Al-Kuraishy, Nawar R Hussian, Marwa S Al-Naimi, Ali I Al-Gareeb, Farah Al-Mamorri, Ali K Al-Buhadily   +5 more
doaj   +1 more source

Gamma-aminobutyric acid as a potential postbiotic mediator in the gut–brain axis

npj Science of Food
Gamma-aminobutyric acid (GABA) plays a crucial role in the central nervous system as an inhibitory neurotransmitter. Imbalances of this neurotransmitter are associated with neurological diseases, such as Alzheimer’s and Parkinson’s disease, and ...
Jason D. Braga, M. Thongngam, Thanutchaporn Kumrungsee   +2 more
semanticscholar   +1 more source

Restoration of gamma-aminobutyric acid homeostasis: A novel approach to alleviating central nervous system injury–associated immunodepression syndrome

Neural Regeneration Research
Injuries to the central nervous system can disrupt body functions and often cause excessive sympathetic activity, leading to immune suppression known as central nervous system injury–associated immunodepression syndrome.
Ping Yang, Di Tian, Zijiao Li, Zhongxiang Yao   +3 more
doaj   +1 more source

A systematic review of Gamma-aminobutyric Acid Receptor Type B autoimmunity.

Neurologia i Neurochirurgia Polska, 2018
OBJECTIVE To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies.
Jake H. McKay, E. Dimberg, A. S. Lopez Chiriboga   +2 more
semanticscholar   +1 more source

Chronic myocardial infarction changed the excitatory–inhibitory synaptic balance in the medial prefrontal cortex of rat

Molecular Pain, 2018
The medial prefrontal cortex is a key area for the regulation of pain and emotion. However, the functional involvement of the medial prefrontal cortex for visceral nociception, at the neuronal or synaptic level, is obscure yet.
Jing Li
doaj   +1 more source

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

Cell Reports, 2018
Summary: Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation ...
Ryutaro Ikegami, Ippei Shimizu, Takeshi Sato, Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Goro Katsuumi, Ji Li, Takayuki Wakasugi, Yasuhiko Minokoshi, Shiki Okamoto, Eiichi Hinoi, Søren Nielsen, Naja Zenius Jespersen, Camilla Scheele, Tomoyoshi Soga, Tohru Minamino   +16 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells

Cell Reports, 2016
The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enables us to ...
Jorge E. Ramirez, Brandon M. Stell
doaj   +1 more source

Extracellular expression of glutamate decarboxylase B in Escherichia coli to improve gamma-aminobutyric acid production

AMB Express, 2016
Escherichia coli overexpressing glutamate decarboxylase GadB can produce gamma-aminobutyric acid with addition of monosodium glutamate. The yield and productivity of gamma-aminobutyric acid might be significantly improved if the overexpressed GadB in E ...
Anqi Zhao, Xiaoqing Hu, Ye Li, Cheng Chen, Xiaoyuan Wang   +4 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source