Results 1 to 10 of about 2,706,998 (267)

Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Nature Communications, 2022
Neuromedin U receptors (NMURs) are potential drug targets for obesity and inflammatory disorders. Here, the authors report structural basis for neuromedin recognition and activation mechanism of NMURs.
Chongzhao You, Yumu Zhang, Peiyu Xu, Sijie Huang, Wanchao Yin, H. Eric Xu, Yi Jiang   +6 more
doaj   +1 more source

Central Role of the EGF Receptor in Neurometabolic Aging

International Journal of Endocrinology, 2012
A strong connection between neuronal and metabolic health has been revealed in recent years. It appears that both normal and pathophysiological aging, as well as neurodegenerative disorders, are all profoundly influenced by this “neurometabolic ...
Sana Siddiqui, Meng Fang, Bin Ni, Daoyuan Lu, Bronwen Martin, Stuart Maudsley   +5 more
doaj   +1 more source

Structural insight into small molecule action on Frizzleds

Nature Communications, 2020
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far.
Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Jana Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, Asuka Inoue, Carsten Hoffmann, Gunnar Schulte   +9 more
doaj   +1 more source

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Nature Communications, 2017
The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading ...
Ido Goldstein, Ville Paakinaho, Songjoon Baek, Myong-Hee Sung, Gordon L. Hager   +4 more
doaj   +1 more source

Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A

Cell Discovery, 2022
5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/o protein. It is involved in nervous system regulation and an attractive target for the treatment of psychosis, depression, schizophrenia, and ...
Yangxia Tan, Peiyu Xu, Sijie Huang, Gong Yang, Fulai Zhou, Xinheng He, Honglei Ma, H. Eric Xu, Yi Jiang   +8 more
doaj   +1 more source

Cryo-EM structure of the human histamine H1 receptor/Gq complex

Nature Communications, 2021
Histamine receptors are effective targets for allergy treatments and antihistamines are the first choice of many allergic disorders, but the exact mechanism of agonist binding and receptor activation remain unknown.
Ruixue Xia, Na Wang, Zhenmei Xu, Yang Lu, Jing Song, Anqi Zhang, Changyou Guo, Yuanzheng He   +7 more
doaj   +1 more source

Single-molecule analysis of steroid receptor and cofactor action in living cells

Nature Communications, 2017
Transcription factors (TFs) are thought to regulate gene expression by stably binding to target DNA elements. Here, the authors use single-molecule tracking to analyse the dynamic behaviour of steroid receptors TFs and show that most specific ...
Ville Paakinaho, Diego M. Presman, David A. Ball, Thomas A. Johnson, R. Louis Schiltz, Peter Levitt, Davide Mazza, Tatsuya Morisaki, Tatiana S. Karpova, Gordon L. Hager   +9 more
doaj   +1 more source

D3PM: a comprehensive database for protein motions ranging from residue to domain

BMC Bioinformatics, 2022
Background Knowledge of protein motions is significant to understand its functions. While currently available databases for protein motions are mostly focused on overall domain motions, little attention is paid on local residue motions.
Cheng Peng, Xinben Zhang, Zhijian Xu, Zhaoqiang Chen, Yanqing Yang, Tingting Cai, Weiliang Zhu   +6 more
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Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

Frontiers in Molecular Neuroscience, 2016
Brain ischemic preconditioning (PC) provides vital insights into the endogenous protection against stroke. Genomic and epigenetic responses to PC condition the brain into a state of ischemic tolerance.
Xiaoyu Yang, Qimei Wu, Lei Zhang, Linyin Feng   +3 more
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Unravelling Convergent Signaling Mechanisms Underlying the Aging-Disease Nexus Using Computational Language Analysis

Current Issues in Molecular Biology
Multiple lines of evidence suggest that multiple pathological conditions and diseases that account for the majority of human mortality are driven by the molecular aging process.
Marina Junyent, Haki Noori, Robin De Schepper, Shanna Frajdenberg, Razan Khalid Abdullah Hussen Elsaigh, Patricia H. McDonald, Derek Duckett, Stuart Maudsley   +7 more
doaj   +1 more source