Results 31 to 40 of about 5,438,451 (166)
D3PM: a comprehensive database for protein motions ranging from residue to domain
BMC Bioinformatics, 2022 Background Knowledge of protein motions is significant to understand its functions. While currently available databases for protein motions are mostly focused on overall domain motions, little attention is paid on local residue motions.
Cheng Peng +6 more
doaj +1 more source
Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling [PDF]
, 2016 G protein-coupled receptors (GPCRs) can initiate intracellular signalling cascades by coupling to an array of heterotrimeric G proteins and arrestin adaptor proteins. Understanding the contribution of each of these coupling options to GPCR signalling has
Alvarez-Curto, Elisa +6 more
core +1 more source
The Cell Density Factor CMF Regulates the Chemoattractant Receptor cAR1 in Dictyostelium [PDF]
, 1996 Starving Dictyostelium cells aggregate by chemotaxis to cAMP when a secreted protein called conditioned medium factor (CMF) reaches a threshold concentration.
Bishop, John D., +2 more
core +4 more sources
Current Issues in Molecular BiologyMultiple lines of evidence suggest that multiple pathological conditions and diseases that account for the majority of human mortality are driven by the molecular aging process.
Marina Junyent +7 more
doaj +1 more source
Auxiliary Subunits: Shepherding AMPA Receptors to the Plasma Membrane
Membranes, 2014 Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated cation channels that mediate excitatory signal transmission in the central nervous system (CNS) of vertebrates.
Simon C. Haering +3 more
doaj +1 more source
Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. [PDF]
, 1980 Protease digestion of acetylcholine receptor-rich membranes derived from Torpedo californica electroplaques by homogenization and isopycnic centrifugation results in degradation of all receptor subunits without any significant effect on the appearance in
Heuser, JE, Klymkowsky, MW, Stroud, RM
core +1 more source
A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal [PDF]
, 2014 A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4 ...
Jin, Cheng Cheng +7 more
core +2 more sources
Nature Communications, 2019 Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a
Shane C. Wright +15 more
doaj +1 more source
Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling
Nature Communications, 2022 aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with Gq, Gs, Gi, G12 and G13 protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and ...
Xinyan Zhu +11 more
doaj +1 more source
Scientific ReportsProgesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome.
Diana A. Stavreva +5 more
doaj +1 more source