Results 31 to 40 of about 2,706,998 (267)

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Nature Communications, 2019
Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identify a
Shane C. Wright, Paweł Kozielewicz, Maria Kowalski-Jahn, Julian Petersen, Carl-Fredrik Bowin, Greg Slodkowicz, Maria Marti-Solano, David Rodríguez, Belma Hot, Najeah Okashah, Katerina Strakova, Jana Valnohova, M. Madan Babu, Nevin A. Lambert, Jens Carlsson, Gunnar Schulte   +15 more
doaj   +1 more source

Auxiliary Subunits: Shepherding AMPA Receptors to the Plasma Membrane

Membranes, 2014
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated cation channels that mediate excitatory signal transmission in the central nervous system (CNS) of vertebrates.
Simon C. Haering, Daniel Tapken, Steffen Pahl, Michael Hollmann   +3 more
doaj   +1 more source

Novel biosensor for high-throughput detection of progesterone receptor-interacting endocrine disruptors

Scientific Reports
Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome.
Diana A. Stavreva, Lyuba Varticovski, Razi Raziuddin, Gianluca Pegoraro, R. Louis Schiltz, Gordon L. Hager   +5 more
doaj   +1 more source

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Nature Communications, 2022
aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with Gq, Gs, Gi, G12 and G13 protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and ...
Xinyan Zhu, Yu Qian, Xiaowan Li, Zhenmei Xu, Ruixue Xia, Na Wang, Jiale Liang, Han Yin, Anqi Zhang, Changyou Guo, Guangfu Wang, Yuanzheng He   +11 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Trio and CRMP2 regulate axon branching and Semaphorin3A signaling

Communications Biology
Trio is a neuronally expressed, Rac1- and RhoA-activating RhoGEF, that is required for neurodevelopment. Mutations affecting the Rac1-activating GEF domain of Trio are associated with profound neurodevelopmental delay and Trio knock-out is embryonic ...
Erin Fingleton, Alexandra Lombardo, Sehoon Won, Kai Chang, Yan Li, Katherine W. Roche   +5 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp3)-H olefination mediated by donor/donor carbenes

Nature Communications, 2021
Furanocembranoid-like natural products with the alkene-substituted furan scaffold display a range of biological activities, but are difficult to access. Here, the authors report a modular biomimetic strategy to synthesise diverse alkene-substituted furan-
Jiping Hao, Xueying Guo, Shijun He, Zhongliang Xu, Lu Chen, Zhongyu Li, Bichao Song, Jianping Zuo, Zhenyang Lin, Weibo Yang   +9 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Immunoprecipitation and Sequencing of Acetylated RNA

Bio-Protocol, 2019
Generation of the epitranscriptome through chemical modifications of protein-coding messenger RNAs (mRNAs) has emerged as a new mechanism of post-transcriptional gene regulation.
Daniel Arango, David Sturgill, Shalini Oberdoerffer   +2 more
doaj   +1 more source