TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide
iScience, 2019 Summary: The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative, 5-carboxylcytosine (5caC), as a factor driving new CTCF binding within genomic DNA ...
Kyster K. Nanan +6 more
doaj +1 more source
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
Nature Communications, 2021 The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands ...
Hui Zhang +11 more
doaj +1 more source
The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]
, 1989 Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F. +24 more
core +1 more source
Structural basis of frizzled 7 activation and allosteric regulation
Nature CommunicationsFrizzleds (ten paralogs: FZD1-10) belong to the class F of G protein-coupled receptors (GPCRs), which remains poorly understood despite its crucial role in multiple key biological functions including embryonic development, stem cell regulation, and ...
Julien Bous +7 more
doaj +1 more source
How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
Nature Communications, 2021 Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy.
Dorien Clarisse, Karolien De Bosscher
doaj +1 more source
Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120 [PDF]
, 2016 It is established that long-chain free fatty acids including ω-3 fatty acids mediate an array of biological responses through members of the free fatty acid receptor family, which includes FFA4.
Alvarez-Curto, Elisa +7 more
core +2 more sources
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Nature Communications, 2017 BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress.
Jinping Liu +6 more
doaj +1 more source
Protein connectivity in chemotaxis receptor complexes [PDF]
, 2015 The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations ...
Eismann, S, Endres, RG
core +4 more sources
Bivariate Genomic Footprinting Detects Changes in Transcription Factor Activity
Cell Reports, 2017 In response to activating signals, transcription factors (TFs) bind DNA and regulate gene expression. TF binding can be measured by protection of the bound sequence from DNase digestion (i.e., footprint).
Songjoon Baek +2 more
doaj +1 more source
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nature Communications, 2022 The basis for the diverse peptide-binding modes and the G protein selectivity of peptide GPCRs remains elusive. Here, the authors offer a structural basis for allosteric-like agonism and G protein selectivity of a neuropeptide GPCR, galanin receptor.
Jia Duan +18 more
doaj +1 more source