Results 1 to 10 of about 6,470,327 (195)

Uncovering the Connectivity Logic of the Ventral Tegmental Area [PDF]

Frontiers in Neural Circuits, 2022
Decades of research have revealed the remarkable complexity of the midbrain dopamine (DA) system, which comprises cells principally located in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc).
Pieter Derdeyn, May Hui, Desiree Macchia, Kevin T. Beier, Kevin T. Beier, Kevin T. Beier, Kevin T. Beier, Kevin T. Beier   +7 more
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Ventral tegmental area afferents and drug-dependent behaviors [PDF]

Frontiers in Psychiatry, 2016
Drug-related behaviors in both humans and rodents are commonly thought to arise from aberrant learning processes. Preclinical studies demonstrate that the acquisition and expression of many drug-dependent behaviors involves the ventral tegmental area ...
Idaira eOliva, Matthew eWanat
doaj   +3 more sources

Anatomy and Function of Ventral Tegmental Area Glutamate Neurons

Frontiers in Neural Circuits, 2022
The ventral tegmental area (VTA) is well known for regulating reward consumption, learning, memory, and addiction behaviors through mediating dopamine (DA) release in downstream regions.
Jing Cai, Jing Cai, Qingchun Tong, Qingchun Tong   +3 more
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Ventral tegmental area GABA neurons integrate positive and negative valence [PDF]

Nature Communications
The ventral tegmental area (VTA) is classically linked to learning and reinforcement via the actions of dopamine neurons. Intermingled VTA GABA neurons are positioned to regulate dopamine, but we lack detailed insight into how this population contributes
Margaret E. Stelzner, Amy R. Wolff, Benjamin T. Saunders   +2 more
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Identification of rat ventral tegmental area GABAergic neurons. [PDF]

PLoS ONE, 2012
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons.
Elyssa B Margolis, Brian Toy, Patricia Himmels, Marisela Morales, Howard L Fields   +4 more
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Timing and expectation of reward: a neuro-computational model of the afferents to the ventral tegmental area

Frontiers in Neurorobotics, 2014
Neural activity in dopaminergic areas such as the ventral tegmental area is influenced by timing processes, in particular by the temporal expectation of rewards during Pavlovian conditioning.
Julien eVitay, Fred H Hamker
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Anticipatory pleasure predicts effective connectivity in the mesolimbic system

Frontiers in Behavioral Neuroscience, 2015
Convergent evidence suggests the important role of the mesolimbic pathway in anticipating monetary rewards. However, the underlying mechanism of how the sub-regions interact with each other is still not clearly understood.
Zhi eLi, Zhi eLi, Chao eYan, Wei-zhen eXie, Ke eLi, Ya-wei eZeng, Zhen eJin, Eric F. C. Cheung, Raymond C. K. Chan   +8 more
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Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections

Nature Communications, 2021
The authors show that terminal activity of dopaminergic neurons selectively projecting from the ventral tegmental area to the lateral septum is sufficient for promoting aggression and necessary for establishing baseline aggression in mice.
Darshini Mahadevia, Rinki Saha, Alessia Manganaro, Nao Chuhma, Annette Ziolkowski-Blake, Ashlea A. Morgan, Dani Dumitriu, Stephen Rayport, Mark S. Ansorge   +8 more
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Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise

Molecular Pain, 2016
Background Exercise alleviates pain and it is a central component of treatment strategy for chronic pain in clinical setting. However, little is known about mechanism of this exercise-induced hypoalgesia.
Kenta Wakaizumi MD, Takashige Kondo BS, Yusuke Hamada BS, Michiko Narita BS, Rui Kawabe BS, Hiroki Narita, Moe Watanabe MS, Shigeki Kato PhD, Emiko Senba MD, PhD, Kazuto Kobayashi PhD, Naoko Kuzumaki PhD, Akihiro Yamanaka PhD, Hiroshi Morisaki MD, PhD, Minoru Narita PhD   +13 more
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Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice

Nature Communications, 2022
Solié, Contestabile et al. show that the superior colliculus to ventral tegmental area (VTA) pathway encodes orienting behavior toward conspecifics, and modulates VTA dopamine neurons projecting onto dorsolateral striatum perturbing social interaction.
Clément Solié, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone   +7 more
doaj   +1 more source