Results 1 to 10 of about 66,367 (159)

Orexinergic input to dopaminergic neurons of the human ventral tegmental area. [PDF]

PLoS ONE, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
Erik Hrabovszky, Csilla S Molnár, Beáta Á Borsay, Péter Gergely, László Herczeg, Zsolt Liposits   +5 more
doaj   +9 more sources

Ventral tegmental area GABA neurons integrate positive and negative valence [PDF]

Nature Communications
The ventral tegmental area (VTA) is classically linked to learning and reinforcement via the actions of dopamine neurons. Intermingled VTA GABA neurons are positioned to regulate dopamine, but we lack detailed insight into how this population contributes
Margaret E. Stelzner, Amy R. Wolff, Benjamin T. Saunders   +2 more
doaj   +2 more sources

Identification of rat ventral tegmental area GABAergic neurons. [PDF]

PLoS ONE, 2012
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons.
Elyssa B Margolis, Brian Toy, Patricia Himmels, Marisela Morales, Howard L Fields   +4 more
doaj   +1 more source

Anatomy and Function of Ventral Tegmental Area Glutamate Neurons

Frontiers in Neural Circuits, 2022
The ventral tegmental area (VTA) is well known for regulating reward consumption, learning, memory, and addiction behaviors through mediating dopamine (DA) release in downstream regions.
Jing Cai, Jing Cai, Qingchun Tong, Qingchun Tong   +3 more
doaj   +1 more source

Uncovering the Connectivity Logic of the Ventral Tegmental Area

Frontiers in Neural Circuits, 2022
Decades of research have revealed the remarkable complexity of the midbrain dopamine (DA) system, which comprises cells principally located in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc).
Pieter Derdeyn, May Hui, Desiree Macchia, Kevin T. Beier, Kevin T. Beier, Kevin T. Beier, Kevin T. Beier, Kevin T. Beier   +7 more
doaj   +1 more source

Glutamatergic Plasticity in Medial Prefrontal Cortex and Ventral Tegmental Area Following Extended-Access Cocaine Self-Administration [PDF]

, 2011
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the molecular and behavioral plasticity associated with addiction to drugs of abuse.
Ghasemzadeh, Behnam, Giles, Chad, Mantsch, John R., Purgianto, Anthony, Seubert, Chad, Vasudevan, Preethi   +5 more
core   +2 more sources

Timing and expectation of reward: a neuro-computational model of the afferents to the ventral tegmental area

Frontiers in Neurorobotics, 2014
Neural activity in dopaminergic areas such as the ventral tegmental area is influenced by timing processes, in particular by the temporal expectation of rewards during Pavlovian conditioning.
Julien eVitay, Fred H Hamker
doaj   +1 more source

Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression [PDF]

, 2019
One of the core symptoms of major depressive disorder is anhedonia, an inability to experience pleasure. In patients with major depressive disorder, a dysfunctional reward-system may exist, with blunted temporal difference reward-related learning signals
Figueroa, Caroline A., Geugies, Hanneke, Groot, Paul F. C., Marsman, Jan-Bernard C., Mocking, Roel J. T., Ruhé, Henricus G., Schene, Aart H., Servaas, Michelle N., Steele, J. Douglas   +8 more
core   +4 more sources

Rabies screen reveals GPe control of cocaine-triggered plasticity. [PDF]

, 2017
Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results.
AE Stepien, AH Gittis, B Weissbourd, BN Armbruster, Boris D. Heifets, C Hammond, C Lüscher, Christina K. Kim, CM Bäckman, D Lin, EJ Nestler, ES Boyden, F-M Zhou, G Schiavo, H Taniguchi, HH Yin, IR Wickersham, JA Shuen, JS Park, K Miyamichi, K Miyamichi, K Yonehara, Karl Deisseroth, Katherine E. DeLoach, Kevin T. Beier, KF Raab-Graham, KT Beier, L Madisen, L Petreanu, L Ye, LA Gunaydin, LA Schwarz, Lin Wai Hung, Liqun Luo, M Watabe-Uchida, M Xue, MJ Krashes, NR Wall, P Rajasethupathy, Paul Hoerbelt, PE Rothwell, PW Kalivas, RC Pierce, RL Albin, Robert C. Malenka, S Hippenmeyer, S Lammel, S Lammel, SHR Oliet, Sophie Neuner, Timothy J. Mosca, TJ Mosca, TJ Stachniak, TN Lerner, Y Smith   +54 more
core   +2 more sources

Ventral tegmental area afferents and drug-dependent behaviors

Frontiers in Psychiatry, 2016
Drug-related behaviors in both humans and rodents are commonly thought to arise from aberrant learning processes. Preclinical studies demonstrate that the acquisition and expression of many drug-dependent behaviors involves the ventral tegmental area ...
Idaira eOliva, Matthew eWanat
doaj   +1 more source