Results 1 to 10 of about 50,460 (257)

Melatonin attenuates morphine‐induced conditioned place preference in Wistar rats

Brain and Behavior, 2021
Purpose Morphine is the predominantly used drug for postoperative and cancer pain management. However, the abuse potential of morphine is the primary disadvantage of using opioids in pain management.
Fahad S. Alshehri, Badrah S. Alghamdi, Alqassem Y. Hakami, Abdullah A. Alshehri, Yusuf S. Althobaiti   +4 more
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Intrathecal morphine plus general anesthesia in cardiac surgery: effects on pulmonary function, postoperative analgesia, and plasma morphine concentration

Clinics, 2009
OBJECTIVES: To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac surgery. INTRODUCTION: Lung dysfunction increases morbidity and mortality after cardiac surgery.
Luciana Moraes dos Santos, Verônica Cavani Jorge Santos, Silvia Regina Cavani Jorge Santos, Luiz Marcelo Sá Malbouisson, Maria José Carvalho Carmona   +4 more
doaj   +1 more source

Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance. [PDF]

PLoS ONE, 2014
Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of ...
Wen-Jinn Liaw, Cheng-Ming Tsao, Go-Shine Huang, Chin-Chen Wu, Shung-Tai Ho, Jhi-Joung Wang, Yuan-Xiang Tao, Hao-Ai Shui   +7 more
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Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects

Pain Research and Management, 2018
Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods.
Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner   +5 more
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The Effect of Acute and Chronic Morphine on Some Blood Biochemical ‎Parameters in an Inflammatory Condition in Gonadectomized Male Rats [PDF]

Addiction and Health, 2015
Background: Opiates affect blood factors as well as pain and inflammation in a gender-dependent manner. The aim of the present study was to evaluate the effects of morphine on serum glucose, cholesterol, triglycerides, and urea in gonadectomized and ...
Mohadeseh Chahkandi, Nayerreh Askari, Gholamreza Asadikaram   +2 more
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The effectiveness of Patient Controlled Analgesia (PCA) morphine-ketamine compared to Patient Controlled Analgesia (PCA) morphine to reduce total dose of morphine and Visual Analog Scale (VAS) in postoperative laparotomy surgery

Bali Journal of Anesthesiology, 2017
Background: Laparotomy may cause moderate to severe after surgery pain, thus adequate pain management is needed. The addition of ketamine in patient controlled analgesia (PCA) morphine after surgery can be the option.
I Gusti Ngurah Mahaalit Aribawa, Tjokorda Gde Agung Senapathi, Made Wiryana, I Ketut Sinardja, I Gede Budiarta, I Made Gede Widnyana, I Wayan Aryabiantara, Pontisomaya Parami, Pande Nyoman Kurniasari, Adinda Putra Pradhana   +9 more
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Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence

Translational Psychiatry, 2022
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in Wistar rats which shows classic ...
María Elena Quintanilla, Mauricio Quezada, Paola Morales, Pablo Berríos-Cárcamo, Daniela Santapau, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer   +8 more
doaj   +1 more source

Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression

Journal of the Formosan Medical Association, 2016
We previously showed that subsequent intrathecal (i.t.) injection of resveratrol (30 μg) significantly reverses morphine-evoked neuroinflammation in morphine-tolerant rats. The present study examined the underlying mechanism.
Ru-Yin Tsai, Juei-Chii Wang, Kuang-Yi Chou, Chih-Shung Wong, Chen-Hwan Cherng   +4 more
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Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice

Frontiers in Pharmacology, 2023
Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment ...
Eduardo A. V. Marinho, Eduardo A. V. Marinho, Alexandre Justo Oliveira-Lima, Alexandre Justo Oliveira-Lima, Henrique S. Reis, Renan Santos-Baldaia, Raphael Wuo-Silva, Andre W. Hollais, Thais S. Yokoyama, Roberto Frussa-Filho, Lais F. Berro, Lais F. Berro, Lais F. Berro   +12 more
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Significance of Metabolite Ratios in the Interpretation of Segmental Hair Testing Results—Differentiation of Single from Chronic Morphine Use in a Case Series

Metabolites, 2021
In morphine intoxication cases, forensic toxicologists are frequently confronted with the question of if the individual was opioid-tolerant or opioid-naïve, which can be investigated by hair analysis. However, interpretation of results can be challenging.
Milena M. Madry, Sandra N. Poetzsch, Andrea E. Steuer, Thomas Kraemer, Markus R. Baumgartner   +4 more
doaj   +1 more source