Results 21 to 30 of about 50,460 (257)
CPT: Pharmacometrics & Systems Pharmacology, 2022 Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access.
Thomas Duflot +6 more
doaj +1 more source
Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]
Reviews in Clinical Medicine, 2015 Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar +5 more
doaj +3 more sources
Journal of Pharmacological Sciences, 2004 The present study was designed to investigate the pharmacokinetic interaction of morphine with three classes of L-type calcium channel blockers (CCB) and its relationship to morphine-induced mechanical antinociception in mice.
Norifumi Shimizu +6 more
doaj +1 more source
Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +4 more
core +1 more source
Morphine is not a prodrug [PDF]
British Journal of Anaesthesia, 2015 Editor–A prodrug is defined as a medication that is administered in an inactive or less than fully active form and is then converted to its active form through a normal metabolic process (http://en. wikipedia.org/wiki/Prodrug). The title of a recent publication in the British Journal of Analgesia, ‘Morphine-6-glucuronide is responsible for the ...
A, Dahan, J, Lötsch
openaire +2 more sources
The Journal of Physiology, 1974 1. To find the site where morphine acts when producing hyperglycaemia on injection into the cerebral ventricles in unanaesthetized cats, morphine sulphate was infused or injected through an implanted Collison cannula into different parts of the liquor space in an amount of 0·75 mg except on microinfusion into the posterior hypothalamus, when the ...
W, Feldberg, K P, Gupta
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PSYCHOSIS OF MORPHINISM. [PDF]
JAMA: The Journal of the American Medical Association, 1905 All writers have mentioned the general defective conception of truth and the relation of right and wrong which appears to be a prominent symptom in all persons who use morphia. It is difficult to understand whether this is a veritable paralysis of the higher reasoning centers or a defect of the senses by which distorted conceptions of facts are not ...
openaire +2 more sources
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources
Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine +5 more
core +1 more source
THE TREATMENT OF MORPHINISM. [PDF]
The Lancet, 1909 n ...
Sainsbury, Harrington, Jennings, Oscar
openaire +4 more sources