Results 21 to 30 of about 162,133 (313)

Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]

, 2013
There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine, Sarah Koutnik, Inka Regine Weingaertner, Koutnik, Sarah, Hermann Ammer, Ammer, Hermann   +5 more
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Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects

Pain Research and Management, 2018
Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods.
Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner   +5 more
doaj   +1 more source

Morphine Induces Apoptosis of Human Endothelial Cells through Nitric Oxide and Reactive Oxygen Species Pathways [PDF]

, 2011
Morphine has been widely used for pain management. Other than analgesia, it has effects on vascular endothellial cells, including angiogenesis and apoptosis.
蕭柏妮;張明誠;鄭文芳;陳祈安;林漢威;謝長堯;孫維仁, HSIAO, PU-NI;CHANG, MING-CHENG;CHENG, WEN-FANG;CHEN, CHI-AN;LIN, HAN-WEI;HSIEH, CHANG-YAO;SUN, WEI-ZEN   +1 more
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Morphine-induced taste aversions : A consideration of parameters [PDF]

, 1978
Following consumption of saccharin, groups of rats were injected with various doses of morphine sulfate. Although no aversion was found after one conditioning trial, repeated saccharin-morphine pairings resulted in decreases in consumption of the ...
W.J. Jacobs (16783884), Anthony Riley (14622746), Vincent M. Lolordo (16783887)   +2 more
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The Effect of Acute and Chronic Morphine on Some Blood Biochemical ‎Parameters in an Inflammatory Condition in Gonadectomized Male Rats [PDF]

Addiction and Health, 2015
Background: Opiates affect blood factors as well as pain and inflammation in a gender-dependent manner. The aim of the present study was to evaluate the effects of morphine on serum glucose, cholesterol, triglycerides, and urea in gonadectomized and ...
Mohadeseh Chahkandi, Nayerreh Askari, Gholamreza Asadikaram   +2 more
doaj  

The effectiveness of Patient Controlled Analgesia (PCA) morphine-ketamine compared to Patient Controlled Analgesia (PCA) morphine to reduce total dose of morphine and Visual Analog Scale (VAS) in postoperative laparotomy surgery

Bali Journal of Anesthesiology, 2017
Background: Laparotomy may cause moderate to severe after surgery pain, thus adequate pain management is needed. The addition of ketamine in patient controlled analgesia (PCA) morphine after surgery can be the option.
I Gusti Ngurah Mahaalit Aribawa, Tjokorda Gde Agung Senapathi, Made Wiryana, I Ketut Sinardja, I Gede Budiarta, I Made Gede Widnyana, I Wayan Aryabiantara, Pontisomaya Parami, Pande Nyoman Kurniasari, Adinda Putra Pradhana   +9 more
doaj   +1 more source

A Nine-Step Formal Synthesis of (±)-Morphine [PDF]

, 2019
A nine-step stereoselective formal synthesis of (±)-morphine from readily available o-vanillin is presented. The carbocyclic structure of morphine was quickly assembled through an orchestration of the intermolecular Diels–Alder/Claisen/Friedel–Crafts ...
Louis Barriault, Amandine Xolin, Julie Brousseau, Amandine Xolin (6382523), Louis Barriault (1590244), Julie Brousseau (6382520)   +5 more
core   +1 more source

Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence

Translational Psychiatry, 2022
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in Wistar rats which shows classic ...
María Elena Quintanilla, Mauricio Quezada, Paola Morales, Pablo Berríos-Cárcamo, Daniela Santapau, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer   +8 more
doaj   +1 more source

Context-dependent effects of the CB1 receptor antagonist rimonabant on morphine-induced behavioral sensitization in female mice

Frontiers in Pharmacology, 2023
Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment ...
Eduardo A. V. Marinho, Eduardo A. V. Marinho, Alexandre Justo Oliveira-Lima, Alexandre Justo Oliveira-Lima, Henrique S. Reis, Renan Santos-Baldaia, Raphael Wuo-Silva, Andre W. Hollais, Thais S. Yokoyama, Roberto Frussa-Filho, Lais F. Berro, Lais F. Berro, Lais F. Berro   +12 more
doaj   +1 more source

Intrathecal Morphine versus Morphine-Dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement: A Randomized Controlled Trial [PDF]

, 2023
Amany F Omara,1 Hadal Hassan Mohsen,2 Alaa Mohammed Abo Hagar,1 Ahmed F Abdelrahman1 1Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Anaesthesia and Surgical Intensive Care ...
Mohammed Abo Hagar A, Mohsen HH, Abdelrahman AF, Omara AF   +3 more
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