Results 1 to 10 of about 24,480 (215)
The Influence of Topiramate on Morphine Dependence in Mice. [PDF]
BiomoleculesTopiramate evokes pharmacological activity via a blockade of voltage-dependent sodium channels, reduction in glutamate release, inhibition of AMPA receptors and kainate receptors, and potentiation of GABAergic neurotransmission. Therefore, it is used not only as an antiseizure drug but is also effective in migraine prophylaxis, cluster headaches ...
Pysiewicz A +7 more
europepmc +5 more sources
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. [PDF]
Sci Rep, 2018 AbstractOpioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use. In the current study, a morphine-murine model was used to investigate the role of the gut microbiome and metabolome as a ...
Wang F +5 more
europepmc +4 more sources
Preference for Morphine and Drug-Seeking Behavior in Morphine Dependent Rats.
Japanese Journal of Pharmacology, 1978 We have already reported that morphine pretreated rats prefered morphine-admixed food during choice trials with the two cup method. In the present work, we utilized both the five and two cup methods and observed the preference for morphine in rats forcedly pretreated with the drug and the increasing rate of preference for the drug in rats where the ...
YANAURA, Saizo, SUZUKI, Tsutomu
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Fatal dependence on kaolin and morphine mixture [PDF]
Postgraduate Medical Journal, 1980 Summary A patient is described who had a long history of abuse of kaolin and morphine mixture which ultimately proved fatal.
J M, Barragry, D V, Morris
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The role of mPer1 in morphine dependence in mice [PDF]
Neuroscience, 2005 Investigations using Drosophila melanogaster have shown that the circadian clock gene period can influence behavioral responses to cocaine, and the mouse homologues, mPer1 and mPer2, modulate cocaine sensitization and reward. In the present study, we applied DNAzyme targeting mPer1 to interfere the expression of mPer1 in CNS in mice and studied the ...
Y, Liu +9 more
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Rat brain proteome in morphine dependence
Neurochemistry International, 2006 The aim of this study was to reveal potential markers associated with drug dependence, using the proteomic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem ...
Bierczyńska-Krzysik, Anna +8 more
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Dopamine-dependent responses to morphine depend on glucocorticoid receptors [PDF]
Proceedings of the National Academy of Sciences, 1998 Previous work has shown that glucocorticoid hormones facilitate the behavioral and dopaminergic effects of morphine. In this study we examined the possible role in these effects of the two central corticosteroid receptor types: mineralocorticoid receptor (MR), and glucocorticoid receptor (GR).
Marinelli, M +4 more
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How lidocaine acts in morphine dependency
Neurosciences, 2006 OBJECTIVE: To study the effect of analgesia caused by a local anesthetic agent (Lidocaine) in morphine dependent and independent rats. METHODS: We carried out this experimental study in the Neuroscience Research Center of Kerman Medical University, Iran in 2003. We evaluated 2 groups of morphine dependent and independent rats.
Behnaz, Sedighi +3 more
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Micturition in naive and morphine‐dependent rats [PDF]
British Journal of Pharmacology, 1986 Voiding responses were recorded in conscious water-loaded rats. Morphine sulphate (5 mg kg-1) elevated the volume threshold for micturition (MV); the group mean MV of 16 rats after morphine was 40% larger than control. Micturition was nevertheless complete since no urine remained in the bladder afterwards.
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Does Morphine Exposure Before Gestation Change Anxiety-Like Behavior During Morphine Dependence in Male Wistar Rats? [PDF]
Addict Health, 2023 Sabzevari S +5 more
europepmc +1 more source