The Influence of Topiramate on Morphine Dependence in Mice [PDF]
BiomoleculesTopiramate evokes pharmacological activity via a blockade of voltage-dependent sodium channels, reduction in glutamate release, inhibition of AMPA receptors and kainate receptors, and potentiation of GABAergic neurotransmission. Therefore, it is used not
Adrian Pysiewicz +7 more
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The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar ...
Iman Fatemi +6 more
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Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes [PDF]
Molecules, 2018 Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood. Astrocytes aggravate the pathological process in their neighboring cellsthrough exosomes in central nervous system diseases ...
Jinying Ou +11 more
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Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K [PDF]
Journal of Ginseng Research, 2016 Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng
Taddesse Yayeh +3 more
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Modulation of oxidative stress/NMDA/nitric oxide pathway by topiramate attenuates morphine dependence in mice [PDF]
HeliyonMorphine belongs to the class of opioids and is known for its potential to cause dependence and addiction, particularly with prolonged use. Due to the associated risks, caution must be taken when prescribing and limiting its clinical use.
Shabir Hussain +5 more
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KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice. [PDF]
PLoS BiologyHeterologous sensitization of adenylyl cyclase (AC) results in elevated cAMP signaling transduction that contributes to drug dependence. Inhibiting cullin3-RING ligases by blocking the neddylation of cullin3 abolishes heterologous sensitization, however,
Zhong Ding +5 more
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Impact of antibiotic-induced gut microbiota modulation on morphine analgesia, tolerance, withdrawal, and neurophysiological changes in mice [PDF]
Scientific ReportsMorphine, a potent opioid analgesic, is limited in clinical use due to tolerance, dependence, and withdrawal. Recent research highlights the gut microbiota as a crucial regulator of opioid effects through the microbiota-gut-brain axis.
Zahra Jokar +5 more
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Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
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The role of hippocampal glial glutamate transporter (GLT‐1) in morphine‐induced behavioral responses
Brain and Behavior, 2021 Opioid abuse modifies synaptic plasticity, which leads to behavioral changes, such as morphine dependence, but the mechanism remains poorly understood.
Negin Saeedi +7 more
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Frontiers in Microbiology, 2020 Morphine is one of the most severely abused drugs in the world. Previous research on morphine addiction has focused on the central nervous system (CNS). Studies have shown that a two-way regulation of the brain and gut microbiota (GM), suggesting a link ...
Zhu Chen +8 more
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