Results 41 to 50 of about 25,962 (253)

Impairment of value-based decision-making in morphine-dependent rats is partly related to neural connectivity between the anterior cingulate cortex and basolateral amygdala

EXCLI Journal : Experimental and Clinical Sciences
Previous studies have established that the amygdala specifically the basolateral amygdala (BLA), has a fundamental role in decision-making. The present study aimed to investigate functional and neural synchronization between the BLA and anterior ...
Zahra Fatahi, Mohammad Fatahi, Abbas Haghparast   +2 more
doaj   +1 more source

The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine-induced conditioned place preference in male rat

Research in Pharmaceutical Sciences, 2023
Background and purpose: The central nucleus of the amygdala (CeA) is one of the nuclei involved in the reward system. The aim of the current study was to investigate the electrical stimulation (e-stim) effect of the CeA in combination with dopamine D1 ...
Zahra Jokar, Saeed Khatamsaz, Hojjatallah Alaei, Mehrdad Shariati   +3 more
doaj   +1 more source

How lidocaine acts in morphine dependency

Neurosciences, 2006
OBJECTIVE: To study the effect of analgesia caused by a local anesthetic agent (Lidocaine) in morphine dependent and independent rats. METHODS: We carried out this experimental study in the Neuroscience Research Center of Kerman Medical University, Iran in 2003. We evaluated 2 groups of morphine dependent and independent rats.
Behnaz, Sedighi, Abbas, Haghparast, Tajpary, Klantary, Maryam, Taieban   +3 more
openaire   +2 more sources

Micturition in naive and morphine‐dependent rats [PDF]

British Journal of Pharmacology, 1986
Voiding responses were recorded in conscious water-loaded rats. Morphine sulphate (5 mg kg-1) elevated the volume threshold for micturition (MV); the group mean MV of 16 rats after morphine was 40% larger than control. Micturition was nevertheless complete since no urine remained in the bladder afterwards.
openaire   +2 more sources

Preoperative Risk Factors for Opioid Use Predict Self‐Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To identify risk factors that predict the need for rescue opioid use and patient‐reported outcomes following an opioid‐limiting postoperative analgesia protocol after anterior cruciate ligament reconstruction. Methods This prospective cohort study recruited 44 patients undergoing primary arthroscopic‐assisted anterior cruciate ligament ...
Eric V. Neufeld, William DeGouveia, Camille Pinpin, Matthew Zinner, Michael J. Sayegh, Michael J. Meade, Steven E. Rokito   +6 more
wiley   +1 more source

The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023
Background and Objectives: Studies have indicated that the chronic use of morphine can result in physical and psychological dependence. Morphine dependence is associated with several cellular and molecular alterations in the mesocorticolimbic system, and
Sahar Khalili Samani, Solmaz Khalifeh, Mehdi Vahiddastjerdi, Mandana Hassanzad, Afshin Kheradmand, Farzaneh Nazari Serenjeh   +5 more
doaj  

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

ffects of morphine_ dependence on the induction and modulation of epileptic seizures in rats [PDF]

Journal of Kerman University of Medical Sciences, 1997
Kindling is a very suitable animal model for studying basis mechanisms of epilepsy. In this model , repeated exposure to weak electrical or chemical increases neuronal excitability and there fore decreases the threshold for induction of epileptic ...
N Atapour, M Niyazi
doaj  

Matricaria chamomilla Extract Inhibits Both Development of Morphine Dependence and Expression of Abstinence Syndrome in Rats

Journal of Pharmacological Sciences, 2003
The effect of Matricaria chamomilla (M. chamomilla) on the development of morphine dependence and expression of abstinence was investigated in rats.
Adel Gomaa, Tahia Hashem, Mahmoud Mohamed, Esraa Ashry   +3 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source