Results 51 to 60 of about 54,444 (297)

Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]

Reviews in Clinical Medicine, 2015
Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar, Golnaz Vaseghi, Mahmoud Rafieian-Kopaei, Sasan Andalib, Azadeh Eshraghi, Nooshin Masoudian   +5 more
doaj   +3 more sources

The significance of the adenosinergic system in morphine dependence

Current Issues in Pharmacy and Medical Sciences, 2015
Addiction is a chronic and recurrent disease. In its pathology, neuroadaptive changes within the dopaminergic pathways inside the mesolimbic system play a predominant role.
Lupina Malgorzata, Listos Joanna
doaj   +1 more source

Family Related Factors and Concurrent Heroin Use in Methadone Maintenance Treatment in China. [PDF]

, 2018
BackgroundThe use of heroin during Methadone Maintenance Treatment (MMT) is a challenging problem that contributes to poor treatment outcomes. Families may play an important role in addressing concurrent heroin use during MMT, especially in collectivist ...
Feng, Nan, Hsieh, Julie, Li, Li, Lin, Chunqing, Rou, Keming   +4 more
core   +1 more source

Effect of oxycodone vs. morphine as first‐line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Postoperative opioids, intended for short‐term analgesia, contribute to new persistent opioid use in 1%–7% of patients, adversely affecting outcomes. Oxycodone may carry higher risk than morphine, though long‐term data are limited.
Eward J. Melis, Johanna E. Vriezekolk, Frédérique H. C. Bollen, Dirk E. Schrander, Arnt F. A. Schellekens, Bart J. F. van den Bemt   +5 more
wiley   +1 more source

Attenuation of morphine tolerance and dependence by thymoquinone in mice [PDF]

Avicenna Journal of Phytomedicine, 2016
Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were ...
Hossein Hosseinzadeh, Siavash Parvardeh, Alireza Masoudi, Mahsa Moghimi, Fatemeh Mahboobifard   +4 more
doaj  

Antinociceptive Activity and Effect of Methanol Extracts of Three Salvia Spp. on Withdrawal Syndrome in Mice [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: There are several reports about effects of Salvia spp. on CNS. The present experiment is undertaken to study effect of S. limbata, S. hypoleuca and S. macrosiphon on withdrawal syndrome in mice.
Mohammad Karami, Mohammad Mehdi Shamerani, Ebrahim Hossini, Ahmad Reza Gohari, Mohammad Ali Ebrahimzadeh, Anahita Nosrati   +5 more
doaj   +1 more source

Pathological regional blood flow in opiate-dependent patients during withdrawal: A HMPAO-SPECT study [PDF]

, 1998
The aims of the present study were to investigate regional cerebral blood flow (rCBF) in heroin-dependent patients during withdrawal and to assess the relation between these changes and duration of heroin consumption and withdrawal data.
Biersack, H. J., Broich, K., Danos, P., Grunwald, F., Hoflich, G., Kasper, S., Klemm, E., Krappel, C., Möller, Hans-Jürgen, Overbeck, B.   +9 more
core   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Morphine Reduces Expression of TRPV1 Receptors in the Amygdala but not in the Hippocampus of Male Rats

Iranian Journal of Medical Sciences, 2014
Background: Chronic use of opioids usually results in physical dependence. The underlying mechanisms for this dependence are still being evaluated. Transient receptor potential vanilloid type 1 (TRPV1) are important receptors of pain perception.
Elham Hakimizadeh, Mohammad Kazemi Arababadi, Ali Shamsizadeh, Mohammad Allahtavakoli, Mohammad*Ebrahim Rezvani, Ali Roohbakhsh   +5 more
doaj  

Impairment of value-based decision-making in morphine-dependent rats is partly related to neural connectivity between the anterior cingulate cortex and basolateral amygdala

EXCLI Journal : Experimental and Clinical Sciences
Previous studies have established that the amygdala specifically the basolateral amygdala (BLA), has a fundamental role in decision-making. The present study aimed to investigate functional and neural synchronization between the BLA and anterior ...
Zahra Fatahi, Mohammad Fatahi, Abbas Haghparast   +2 more
doaj   +1 more source