Results 1 to 10 of about 80,877 (282)

Estimating naloxone need in the USA across fentanyl, heroin, and prescription opioid epidemics: a modelling study

The Lancet Public Health, 2022
Summary: Background: The US overdose crisis is driven by fentanyl, heroin, and prescription opioids. One evidence-based policy response has been to broaden naloxone distribution, but how much naloxone a community would need to reduce the incidence of ...
Michael A Irvine, PhD, Declan Oller, PhD, Jesse Boggis, MPH, Brian Bishop, PharmD, Daniel Coombs, ProfPhD, Eliza Wheeler, MPA, Maya Doe-Simkins, MPH, Alexander Y Walley, ProfMD, Brandon D L Marshall, PhD, Jeffrey Bratberg, PharmD, Traci C Green, ProfPhD   +10 more
doaj   +2 more sources

Nobody Wants to Be Narcan’d: A Pilot Qualitative Analysis of Drug Users’ Perspectives on Naloxone

Western Journal of Emergency Medicine, 2020
Introduction: Bystander naloxone distribution is an important component of public health initiatives to decrease opioid-related deaths. While there is evidence supporting naloxone distribution programs, the effects of increasing naloxone availability on ...
Jeffrey T. Lai, Charlotte E. Goldfine, Brittany P. Chapman, Melissa M. Taylor, Rochelle K. Rosen, Stephanie P. Carreiro, Kavita M. Babu   +6 more
doaj   +2 more sources

Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

BMC Public Health, 2021
Background Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged as a key intervention in reducing opioid overdose ...
Amina Moustaqim-Barrette, Damon Dhillon, Justin Ng, Kristen Sundvick, Farihah Ali, Tara Elton-Marshall, Pamela Leece, Katherine Rittenbach, Max Ferguson, Jane A. Buxton   +9 more
doaj   +2 more sources

Reciprocal influences between overdose experiences and naloxone access among people who use drugs utilizing a syringe services program: a cross-lagged panel model [PDF]

Harm Reduction Journal
Background The opioid epidemic continues to be one of the most pressing public health crises in the United States, with more than 80,000 overdose deaths in 2024.
Marina Plesons, Tyler Bartholomew, Hansel Tookes, Daniel Feaster   +3 more
doaj   +2 more sources

Preventing opioid overdose with peer-administered naloxone: findings from a rural state

Harm Reduction Journal, 2020
Background In response to the opioid epidemic, naloxone distribution programs aim to prevent overdose death by making naloxone available and training people to use it.
Bridget L. Hanson, Rebecca R. Porter, Amanda L. Zöld, Heather Terhorst-Miller   +3 more
doaj   +2 more sources

Are take‐home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria

Addiction, 2016
Background and Aims Fatal outcome of opioid overdose, once detected, is preventable through timely administration of the antidote naloxone. Take‐home naloxone provision directly to opioid users for emergency use has been implemented recently in more than
John Strang, Rebecca Mcdonald
exaly   +2 more sources

Impact of a community-based naloxone distribution program on opioid overdose death rates

Drug and Alcohol Dependence, 2019
Background: In August 2013, a naloxone distribution program was implemented in North Carolina (NC). This study evaluated that program by quantifying the association between the program and county-level opioid overdose death (OOD) rates and conducting a ...
Meghan Shanahan, Anna Austin, Stephen Marshall   +2 more
exaly   +2 more sources

Beyond access: improving real-world naloxone use to address the opioid overdose epidemic [PDF]

International Journal of Emergency Medicine
James Neuenschwander, R. Gentry Wilkerson, Scott G. Weiner   +2 more
doaj   +2 more sources

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level.

PLoS ONE, 2020
Rapid resuscitation of an opioid overdose with naloxone, an opioid antagonist, is critical. We developed an opioid receptor quantitative systems pharmacology (QSP) model for evaluation of naloxone dosing.
Ronald B Moss, Meghan McCabe Pryor, Rebecca Baillie, Katherine Kudrycki, Christina Friedrich, Mike Reed, Dennis J Carlo   +6 more
doaj   +2 more sources

Racial/ethnic disparities in opioid overdose prevention: comparison of the naloxone care cascade in White, Latinx, and Black people who use opioids in New York City

Harm Reduction Journal, 2023
Background Drug overdose mortality is rising precipitously among Black people who use drugs. In NYC, the overdose mortality rate is now highest in Black (38.2 per 100,000) followed by the Latinx (33.6 per 100,000) and white (32.7 per 100,000) residents ...
Maria R. Khan, Lee Hoff, Luther Elliott, Joy D. Scheidell, John R. Pamplin, T. Townsend, Natalia Irvine, Alex S. Bennett   +7 more
semanticscholar   +1 more source