Results 31 to 40 of about 46,768 (219)

Naltrexone, Naloxone, Morphine, and Fentanyl Pharmacologically Chaperone a Mutant μ-Opioid Receptor via an Endoplasmic Reticulum Exit Site-Dependent Pathway. [PDF]

Pharmacol Res Perspect
ABSTRACT Opioid receptor antagonists increase the plasma membrane density of μ‐opioid receptors (MOR) in vivo, thereby inducing “supersensitivity” to opioid agonists. This phenomenon increases the risk of overdose in patients that were being treated with naltrexone (Ntx), a popular MOR antagonist.
Grant SN, Mulcahy MJ, Lester HA.
europepmc   +2 more sources

Naloxone and Metabolites Quantification in Cord Blood of Prenatally Exposed Newborns and Correlations with Maternal Concentrations

American Journal of Perinatology Reports, 2016
Objective To quantify naloxone and metabolite concentrations in newborns prenatally exposed to sublingual buprenorphine/naloxone and to correlate neonatal and maternal metabolite concentrations.
Samantha L. Wiegand, Madeleine J. Swortwood, Marilyn A. Huestis, John Thorp, Hendreé E. Jones, Neeta L. Vora   +5 more
doaj   +1 more source

Characteristics of and Experience Among People Who Use Take-Home Naloxone in Skåne County, Sweden

Frontiers in Public Health, 2022
BackgroundOpioid overdose related injury or death can be prevented by bystander naloxone administration. For naloxone to be present when and where overdoses occur, opioid prevention education and naloxone distribution (OPEND) must be established on a ...
Katja Troberg, Katja Troberg, Pernilla Isendahl, Marianne Alanko Blomé, Marianne Alanko Blomé, Disa Dahlman, Disa Dahlman, Anders Håkansson, Anders Håkansson   +8 more
doaj   +1 more source

Overdose reversal through peer intervention: Findings from the naloxone prospective outcome research study (NalPORS) on the effectiveness of overdose response by people who use opioids in the United Kingdom and Sweden. [PDF]

Addiction
Abstract Background/aims Take‐home naloxone (THN) programmes have been introduced in many European countries to provide non‐medically trained people who are likely to witness an opioid overdose, including people who use opioids, with a naloxone kit and training.
Metrebian N, Dascal T, Mackie C, Tinch-Taylor R, Carter B, Neale J, Utrilla MG, Day E, Guterstam J, Horsburgh K, Kåberg M, Kelleher M, Mayet S, Smith J, Eide D, Holmén E, McDonald R, Parkin S, Thiesen H, Strang J, NalPORS Research Team.   +20 more
europepmc   +2 more sources

The effect of subcutaneous naloxone on experimentally induced pain [PDF]

, 2008
The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surface of each hand, after injection of an opioid antagonist (80 μg naloxone) or vehicle alone (0.2 mL saline) into the burnt skin of 1 hand, and after ...
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core  

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Public Perceptions of Community Pharmacy-Based Naloxone Services: A National Cross-Sectional Survey

Pharmacy, 2022
Little is known about the general public’s perceptions regarding community pharmacist-delivered naloxone services at the national level. Accordingly, the purpose of this study was to describe the US general public’s awareness, knowledge, beliefs, comfort,
Lindsey A. Hohmann, Zach Krauss, Jitisha Patel, Grace T. Marley   +3 more
doaj   +1 more source

Naloxone-AuNPs@ZIF-8-Based Impedimetric Sensor Platform for Ultrasensitive Detection of Fentanyl and Fabrication of Fen-Track Prototype for Real-Field Analysis

, 2023
Opioids are considered to be a global threat, and we are facing the worst opioid crisis of the decade. Synthetic opioids like fentanyl are highly potent and deadly toward human body, and hence its detection is an inevitable requirement globally. Naloxone
Sriram Muthukumar (7511177), Anirban Paul (3489791), Ivneet Kaur Banga (17708855), Shalini Prasad (4276705)   +3 more
core   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria

Advanced Science, EarlyView.
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean‐Philippe Pin   +12 more
wiley   +1 more source

Accessibility of Naloxone in Pharmacies Registered Under the Illinois Standing Order

Western Journal of Emergency Medicine
Introduction: To expand access to naloxone, the state of Illinois implemented a standing order allowing registered pharmacies to dispense the drug without an individual prescription.
P. Quincy Moore, Kaitlin Ellis, Patricia Simmer, Mweya Waetjen, Ellen Almirol, Elizabeth Salisbury-Afshar, Mai T. Pho   +6 more
doaj   +1 more source