Results 41 to 50 of about 45,683 (251)
Naloxone Accessibility Across Mississippi [PDF]
, 2022 Background/Objectives Despite widespread standing orders allowing pharmacies to dispense naloxone under protocol or without a prescription, there is substantial variation in naloxone availability and cost geographically.
Gravlee, Emily
core +1 more source
American Journal of Perinatology Reports, 2016 Objective To quantify naloxone and metabolite concentrations in newborns prenatally exposed to sublingual buprenorphine/naloxone and to correlate neonatal and maternal metabolite concentrations.
Samantha L. Wiegand +5 more
doaj +1 more source
Development of a nalmefene formulation suitable for a community‐use auto‐injector
British Journal of Clinical Pharmacology, EarlyView.Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano +6 more
wiley +1 more source
The effect of subcutaneous naloxone on experimentally induced pain [PDF]
, 2008 The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surface of each hand, after injection of an opioid antagonist (80 μg naloxone) or vehicle alone (0.2 mL saline) into the burnt skin of 1 hand, and after ...
Hammond, G.R. +2 more
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Harm Reduction Journal, 2023 Background Naloxone is a medication that can quickly reverse an opioid overdose. Syringe service programs (SSPs) are community-based prevention programs that provide a range of evidence-based interventions in the USA, including naloxone distribution ...
Barrot H. Lambdin +7 more
doaj +1 more source
Drugs in Context, 2021 Background: Older adults (≥65 years) have seen significant increases in opioid overdose deaths. Diversion of older adults’ opioid medication is also a contributor to opioid misuse.
Brianna M McQuade +4 more
doaj +1 more source
Paediatric clonidine medication errors: Findings from a multicentre French study
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard +8 more
wiley +1 more source
Accessibility of Naloxone in Pharmacies Registered Under the Illinois Standing Order
Western Journal of Emergency MedicineIntroduction: To expand access to naloxone, the state of Illinois implemented a standing order allowing registered pharmacies to dispense the drug without an individual prescription.
P. Quincy Moore +6 more
doaj +1 more source
Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science
Clinical Pharmacology &Therapeutics, EarlyView.New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova +9 more
wiley +1 more source
Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]
, 2007 The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R. +2 more
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