Results 51 to 60 of about 45,683 (251)

Micro‐QuEChERS Extraction for Broad‐Spectrum LC‐QQQ‐MS Quantification of Nitazene Analogs in Plasma: A Validated Method With Casework Application

Drug Testing and Analysis, EarlyView.
Micro‐QuEChERS sample preparation coupled to LC‐QQQ‐MS enabled sensitive quantification of nitazene analogs in 100 μL of plasma. The validated method provided low detection limits and was successfully applied to an authentic intoxication case involving N‐pyrrolidino protonitazene, supporting clinical and forensic toxicology workflows.
Karla A. O. Souza, Náthaly C. B. F. Santos, Rafael Lanaro, Sara E. Walton, Alex J. Krotulski, Barry K. Logan, Mauricio Yonamine, Jose Luiz Costa   +7 more
wiley   +1 more source

Public Perceptions of Community Pharmacy-Based Naloxone Services: A National Cross-Sectional Survey

Pharmacy, 2022
Little is known about the general public’s perceptions regarding community pharmacist-delivered naloxone services at the national level. Accordingly, the purpose of this study was to describe the US general public’s awareness, knowledge, beliefs, comfort,
Lindsey A. Hohmann, Zach Krauss, Jitisha Patel, Grace T. Marley   +3 more
doaj   +1 more source

Detection of Nitazenes in the Illicit Drug Supply Utilizing Precursor Ion Scan Methods With Paper Spray Mass Spectrometry

Drug Testing and Analysis, EarlyView.
Nitazenes are increasingly present in the illicit drug supply, complicating harm reduction efforts. We have developed a rapid, nontargeted precursor ion scan method to detect emerging nitazenes in real‐world opioid samples. The method identified multiple nitazenes, often replacing pharmaceutical opioids or mixed with fentanyl and benzodiazepines ...
Allie Miskulin, Irene Shkolnikov, Jindar Sboto, Collin Kielty, Bruce Wallace, Chris G. Gill, Dennis K. Hore   +6 more
wiley   +1 more source

Naloxone-AuNPs@ZIF-8-Based Impedimetric Sensor Platform for Ultrasensitive Detection of Fentanyl and Fabrication of Fen-Track Prototype for Real-Field Analysis

, 2023
Opioids are considered to be a global threat, and we are facing the worst opioid crisis of the decade. Synthetic opioids like fentanyl are highly potent and deadly toward human body, and hence its detection is an inevitable requirement globally. Naloxone
Sriram Muthukumar (7511177), Anirban Paul (3489791), Ivneet Kaur Banga (17708855), Shalini Prasad (4276705)   +3 more
core   +1 more source

A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial

Nature Communications
Severe opioid-induced respiratory depression (OIRD) can be treated with intranasal (IN) or intramuscular (IM) naloxone. It is relevant to compare their efficacy and determine the optimal strategy to restore breathing following OIRD.
Maarten A. van Lemmen, Monique van Velzen, Elise Y. Sarton, Albert Dahan, Marieke Niesters, Rutger M. van der Schrier   +5 more
doaj   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, EarlyView.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source

Utilizing a train-the-trainer model for multi-site naloxone distribution programs [PDF]

, 2016
BackgroundIn order to have a substantial impact on overdose prevention, the expansion and scaling-up of overdose prevention with naloxone distribution (OPEND) programs are needed.
Lobmaier, Philipp Paul, Clausen, Thomas, Madah-Amiri, Desiree, Lobmaier, Philipp   +3 more
core   +1 more source

Use of nebulized naloxone to reverse methadone overdose – A case report and review of literature

Journal of Community Hospital Internal Medicine Perspectives, 2019
Opioid use is a frequent cause of morbidity and mortality in the USA. We report a case of methadone overdose reversed with naloxone nebulization. Peripheral IV access can be difficult to obtain in patients with a history of IV drug abuse making needless ...
Muhammad Sameed, Heidi Teague
doaj   +1 more source

Addressing in‐hospital substance use: A bioethical evaluation of two possible approaches

Journal of Hospital Medicine, EarlyView.
Abstract Up to 40% of patients with substance use disorder report using non‐prescribed drugs when hospitalized. In‐hospital substance (IHSU) use is associated with poor outcomes and raises safety concerns for healthcare providers. Despite its prevalence, little guidance exists regarding best practices in responding to IHSU.
John C. Messinger, Taylor Baisey, Johanna Sluser, Benjamin A. Barsky, Marlene Martin, Leslie W. Suen   +5 more
wiley   +1 more source

Naloxone Access [PDF]

, 2022
Key Points ● Naloxone is a life-saving opioid antagonist that can reverse an opioid overdose. Tennessee law makes it available to anyone with or without a prescription and protects from civil suit any physician who prescribes it, and any bystander who ...
Kourvelas, Jeremy, Lyons, William, PhD, Tourville, Jennifer G, DNP   +2 more
core