Results 71 to 80 of about 41,379 (243)

The effects of heat and freeze-thaw cycling on naloxone stability

Harm Reduction Journal, 2019
Purpose The availability of take home naloxone (THN) was increased for Canadians in 2016, including access to kits via pharmacies. Unlike typical over-the-counter (OTC) and prescription drugs, THN kits may be stored in non-standard conditions, including ...
Dulcie Lai, Amy Trinh Pham, Praveen P. Nekkar Rao, Michael A. Beazely   +3 more
doaj   +1 more source

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level.

PLoS ONE, 2020
Rapid resuscitation of an opioid overdose with naloxone, an opioid antagonist, is critical. We developed an opioid receptor quantitative systems pharmacology (QSP) model for evaluation of naloxone dosing.
Ronald B Moss, Meghan McCabe Pryor, Rebecca Baillie, Katherine Kudrycki, Christina Friedrich, Mike Reed, Dennis J Carlo   +6 more
doaj   +1 more source

Context, mechanisms and outcomes of a social enterprise model of residential rehabilitation for problem substance use: A realist‐informed process evaluation

Addiction, EarlyView.
Abstract Background and aims This study evaluated a three‐year residential rehabilitation programme, which aimed to support recovery from problem substance use via peer support and social enterprise activities. The aims were to clarify programme mechanisms and identify contextual factors associated with variation in outcomes.
Martin Anderson, Lucy Pickering, Mark McCann   +2 more
wiley   +1 more source

The effect of subcutaneous naloxone on experimentally induced pain

, 2008
The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surface of each hand, after injection of an opioid antagonist (80 μg naloxone) or vehicle alone (0.2 mL saline) into the burnt skin of 1 hand, and after ...
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core  

Bridging the Gap Between Knowledge and Practices Pertaining to Naloxone Use: A Single-Institution Experience in North Carolina

Journal of Patient-Centered Research and Reviews
Naloxone is a life-saving medication for opioid overdose, which claims many lives annually. This study investigated provider attitudes about, beliefs about, and barriers to naloxone use to inform an increase in provider prescription of naloxone.
Michael S. Argenyi, Gisele Bailey, Christopher J. McLouth, Erin Barnes, Candice J. McNeil   +4 more
doaj   +1 more source

Charting the decline of the fourth wave: US overdose deaths by race, ethnicity and substance involvement

Addiction, EarlyView.
Abstract Aims To characterize decreases in overdose death rates in the United States (US) between 2023 and 2024 by race/ethnicity, and substance involvement. Design Population‐based study of national death records accessed via the Centers for Disease Control and Prevention (CDC) Wide‐ranging ONline Data for Epidemiologic Research (WONDER) platform ...
Joseph R. Friedman, Joseph J. Palamar, Daniel Ciccarone, Tommi L. Gaines, Annick Borquez, Chelsea L. Shover, Steffanie A. Strathdee   +6 more
wiley   +1 more source

Naloxone Accessibility Across Mississippi

, 2022
Background/Objectives Despite widespread standing orders allowing pharmacies to dispense naloxone under protocol or without a prescription, there is substantial variation in naloxone availability and cost geographically.
Gravlee, Emily
core  

The association between naloxone distribution, buprenorphine treatment and retention and incident high‐risk opioid prescribing with opioid overdose death in Kentucky, Massachusetts, New York and Ohio, United States: An exploratory community‐level cohort study of data from the HEALing Communities Study

Addiction, EarlyView.
Abstract Aim We evaluated whether community‐level naloxone distribution, medication for opioid use disorder treatment and retention and incident high‐risk opioid prescribing rates were associated with opioid overdose death rates. Design Observational cohort conducted using 2019 to 2023 community‐level data as an exploratory analysis of the HEALing ...
Alexander Y. Walley, Debbie M. Cheng, Nathan Vandergrift, Marc Larochelle, JaNae Holloway, Jennifer L. Brown, Redonna Chandler, Laura C. Fanucchi, Daniel J. Feaster, Patricia R. Freeman, Timothy Hunt, Michelle R. Lofwall, Hannah K. Knudsen, Edward V. Nunes, Emmanuel Oga, Douglas R. Oyler, Jeffrey H. Samet, Jennifer Villani, Sharon L. Walsh, T. John Winhusen   +19 more
wiley   +1 more source

Drug Alcohol Depend [PDF]

Background:Naloxone is a prescription medication that reverses opioid overdoses. Allowing naloxone to be dispensed directly by a pharmacist without an individual prescription under a naloxone standing order (NSO) can expand access.

core   +2 more sources

Characteristics of deaths due to drug‐related causes among individuals recently released from prison in the United Kingdom, 1997–2025

Addiction, EarlyView.
Abstract Background and aims There has been an extensive literature describing the elevated risk of drug‐related death following an individual's release from prison; however, few previous studies have reported nationally representative samples or provided granular detail as to which individual drugs were deemed implicated in death.
Emmert Roberts, John Strang, Caroline Copeland   +2 more
wiley   +1 more source