Results 1 to 10 of about 269,209 (316)

Early innovations in opioid use disorder treatment and harm reduction during the COVID-19 pandemic: a scoping review

Addiction Science & Clinical Practice, 2021
Background The COVID-19 pandemic has exerted a significant toll on the lives of people who use opioids (PWUOs). At the same time, more flexible regulations around provision of opioid use disorder (OUD) services have led to new opportunities for ...
Noa Krawczyk, Adetayo Fawole, Jenny Yang, Babak Tofighi   +3 more
doaj   +1 more source

Naltrexone beyond Psychiatric Domain

Indian Journal of Medical Specialities, 2022
Naltrexone, an opioid receptor (OR) antagonist, at its standard doses, is a United States Federal Drug Administration-approved drug for opioid and alcohol use disorders.
Ashutosh Garg, Khyati Thapliyal, Vivek Pal Singh   +2 more
doaj   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Murányi Marianna, Szűcs, Mária, Dochnal Roberta, Kicsi Emese, Kicsi, Emese Gabriella, Fábián Gabriella, Szabó Gyula, Szabó, Gyula, Zentai, András, Bozó, Beáta, Fábián, Gabriella, Birkás Erika, Cinar Resat, Bozó Bea, Birkás, Erika, Kékesi Orsolya Sára, Cinar, Resat, Tóth, Géza, Mácsai Mónika, Mácsai, Mónika, Kékesi, Orsolya, Dochnal, Roberta Beatrix, Tóth Géza, Szűcs Mária, Murányi, Marianna, Zentai András   +25 more
core   +1 more source

Opioids, opioids, opioids [PDF]

Nordic Studies on Alcohol and Drugs, 2018
Non peer ...
openaire   +3 more sources

Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]

, 2012
Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas, Schwarz, Wolfgang, Xu, Nanjie, Pu, Lu, Pei, Gang, Gu, Quanbao, Xia, Peng, Ren, Shuanglai   +7 more
core   +1 more source

Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

eLife, 2023
Opioids depress breathing by inhibition of interconnected respiratory nuclei in the pons and medulla. Mu opioid receptor (MOR) agonists directly hyperpolarize a population of neurons in the dorsolateral pons, particularly the Kölliker-Fuse (KF) nucleus ...
Jordan T Bateman, Erica S Levitt
doaj   +1 more source

Plasma Pro‐Enkephalin A and Incident Cognitive Impairment: The Reasons for Geographic and Racial Differences in Stroke Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Cardiovascular disease is a risk factor for cognitive impairment. Evidence links both lower and higher concentration of the circulating opioid pro‐enkephalin A (PENK‐A) with stroke risk.
Samuel A. P. Short, Katherine Wilkinson, Janin Schulte, Miguel Arce Renteria, Katharine L. Cheung, Charles D. Nicoli, Virginia J. Howard, Mary Cushman   +7 more
doaj   +1 more source

Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

Molecules, 2021
In this study, we aimed to design and synthesize novel molecules carrying both the thiazole and piperazine rings in their structures and to investigate their antinociceptive activity.
Nazlı Turan Yücel, Derya Osmaniye, Ümmühan Kandemir, Asaf Evrim Evren, Özgür Devrim Can, Ümide Demir Özkay   +5 more
doaj   +1 more source

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium

, 2013
The existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous ...
McMorrow, Jason P., Carey, Michael F., Campion, Deirdre P., O\u27Connor, J. J., Fanning, Rebecca A., O'Connor, J. J.   +5 more
core   +1 more source

MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration

Advances in Drug and Alcohol Research, 2023
Opioid misuse in the United States contributes to >70% of annual overdose deaths. To develop additional therapeutics that may prevent opioid misuse, further studies on the neurobiological consequences of opioid exposure are needed.
Mary Tresa Zanda, Mary Tresa Zanda, Leila Saikali, Leila Saikali, Paige Morris, Paige Morris, Stephanie E. Daws, Stephanie E. Daws   +7 more
doaj   +1 more source