Results 11 to 20 of about 414,966 (313)

Early innovations in opioid use disorder treatment and harm reduction during the COVID-19 pandemic: a scoping review

Addiction Science & Clinical Practice, 2021
Background The COVID-19 pandemic has exerted a significant toll on the lives of people who use opioids (PWUOs). At the same time, more flexible regulations around provision of opioid use disorder (OUD) services have led to new opportunities for ...
Noa Krawczyk, Adetayo Fawole, Jenny Yang, Babak Tofighi   +3 more
doaj   +1 more source

Naltrexone beyond Psychiatric Domain

Indian Journal of Medical Specialities, 2022
Naltrexone, an opioid receptor (OR) antagonist, at its standard doses, is a United States Federal Drug Administration-approved drug for opioid and alcohol use disorders.
Ashutosh Garg, Khyati Thapliyal, Vivek Pal Singh   +2 more
doaj   +1 more source

Laxatives do not improve symptoms of opioid-induced constipation: results of a patient survey [PDF]

, 2017
Introduction: Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a non-specific action and do not target underlying mechanisms of opioid-induced ...
Emmanuel, Anton, Johnson, Martin, McSkimming, Paula   +2 more
core   +1 more source

Opioids, opioids, opioids [PDF]

Nordic Studies on Alcohol and Drugs, 2018
Non peer ...
openaire   +3 more sources

Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms

eLife, 2023
Opioids depress breathing by inhibition of interconnected respiratory nuclei in the pons and medulla. Mu opioid receptor (MOR) agonists directly hyperpolarize a population of neurons in the dorsolateral pons, particularly the Kölliker-Fuse (KF) nucleus ...
Jordan T Bateman, Erica S Levitt
doaj   +1 more source

Opioid Analgesic Prescribing Practices of Dental Professionals in the United States [PDF]

, 2017
The prescription of opioid analgesics by dental professionals is widespread in the United States. Policy makers, government agencies, and professional organizations consider this phenomenon a growing public health concern.
Okunseri, Christopher, Okunseri, Elaye, Steinmetz, C. N., Szabo, Aniko, Zheng, C.   +4 more
core   +2 more sources

Plasma Pro‐Enkephalin A and Incident Cognitive Impairment: The Reasons for Geographic and Racial Differences in Stroke Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Cardiovascular disease is a risk factor for cognitive impairment. Evidence links both lower and higher concentration of the circulating opioid pro‐enkephalin A (PENK‐A) with stroke risk.
Samuel A. P. Short, Katherine Wilkinson, Janin Schulte, Miguel Arce Renteria, Katharine L. Cheung, Charles D. Nicoli, Virginia J. Howard, Mary Cushman   +7 more
doaj   +1 more source

Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

Molecules, 2021
In this study, we aimed to design and synthesize novel molecules carrying both the thiazole and piperazine rings in their structures and to investigate their antinociceptive activity.
Nazlı Turan Yücel, Derya Osmaniye, Ümmühan Kandemir, Asaf Evrim Evren, Özgür Devrim Can, Ümide Demir Özkay   +5 more
doaj   +1 more source

MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration

Advances in Drug and Alcohol Research, 2023
Opioid misuse in the United States contributes to >70% of annual overdose deaths. To develop additional therapeutics that may prevent opioid misuse, further studies on the neurobiological consequences of opioid exposure are needed.
Mary Tresa Zanda, Mary Tresa Zanda, Leila Saikali, Leila Saikali, Paige Morris, Paige Morris, Stephanie E. Daws, Stephanie E. Daws   +7 more
doaj   +1 more source

Discrepancies in Written Versus Calculated Durations in Opioid Prescriptions: Pre-Post Study. [PDF]

, 2020
BACKGROUND: The United States is in the midst of an opioid epidemic. Long-term use of opioid medications is associated with an increased risk of dependence. The US Centers for Disease Control and Prevention makes specific recommendations regarding opioid
Babula, Bracken, Girondo, Melanie, Kairys, John, Martino, Cara, Riggio, Jeffrey, Roke, Lindsey M., Slovis, Benjamin H.   +6 more
core   +1 more source