Results 31 to 40 of about 313,201 (307)

MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration

Advances in Drug and Alcohol Research, 2023
Opioid misuse in the United States contributes to >70% of annual overdose deaths. To develop additional therapeutics that may prevent opioid misuse, further studies on the neurobiological consequences of opioid exposure are needed.
Mary Tresa Zanda, Mary Tresa Zanda, Leila Saikali, Leila Saikali, Paige Morris, Paige Morris, Stephanie E. Daws, Stephanie E. Daws   +7 more
doaj   +1 more source

Real time, on-site drug checking in low-threshold housing communities

Harm Reduction Journal
Background In recent years, Boston has attempted to increase housing options and reduce overdose risk through the implementation of harm reduction housing (HRH) sites.
Charlie Summers, Joseph Silcox, Sofia Zaragoza, Sabrina Rapisarda, Abigail Edelmann, Avik Chatterjee, Traci C. Green   +6 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

Social trauma and the mu-opioid system in depression [PDF]

, 2011
The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate
Malcolm-Smith, Susan
core   +1 more source

Stress-evoked opioid release inhibits pain in major depressive disorder [PDF]

, 2008
To determine whether stress-evoked release of endogenous opioids might account for hypoalgesia in major depressive disorder (MDD), the μ-opioid antagonist naltrexone (50 mg) or placebo was administered double-blind to 24 participants with MDD and to 31 ...
Frew, A.K., Drummond, P.D.
core  

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

A qualitative study of the impacts of a government crackdown against revenue sharing between pharmacies and patients in Vancouver, Canada

Discover Public Health
Background The city of Vancouver, Canada has been under a public health emergency driven by the unregulated toxic drug supply since April 2016. Interventions implemented during the crisis have often been driven by electoral interests, and in turn ...
Tyson Singh Kelsall, Garth Mullins, Hannah Dempsey, BC Association of People on Opioid Maintenance Board of Directors, Ryan McNeil, Thomas Kerr   +5 more
doaj   +1 more source

Cannabis combined with oxycodone for pain relief in fibromyalgia pain: a randomized clinical self-titration trial with focus on adverse events

Frontiers in Pain Research
ObjectivesWe determined whether adding cannabis to oxycodone for chronic non-cancer pain management could reduce treatment-related adverse effects (AEs) while maintaining effective analgesia.MethodsIn this open-label study, fibromyalgia patients aged ≥18 
Cornelis Jan van Dam, Cornelis Jan van Dam, Cornelis Kramers, Cornelis Kramers, Cornelis Kramers, Arnt Schellekens, Arnt Schellekens, Arnt Schellekens, Arnt Schellekens, Marcel Bouvy, Marcel Bouvy, Eveline van Dorp, Eveline van Dorp, Mikael A. Kowal, Erik Olofsen, Albert Dahan, Albert Dahan, Albert Dahan, Albert Dahan, Marieke Niesters, Marieke Niesters, Marieke Niesters, Monique van Velzen, Monique van Velzen   +23 more
doaj   +1 more source

National opioid pharmacotherapy statistics 2014 [PDF]

, 2015
Summary Dependence on opioid drugs is associated with a range of health and social problems that affect individual drug users, their family and friends, and the wider public.
Australian Institute of Health and Welfare
core  

Clinician and Patient Factors Associated With Long‐Term Glucocorticoid Use in People With Rheumatoid Arthritis Receiving Advanced Therapies

Arthritis Care &Research, EarlyView.
Objective Despite guideline recommendations, long‐term glucocorticoid (GC) use is common in rheumatoid arthritis (RA). We conducted a clinician survey nested within a large registry to identify patient and clinician factors associated with GC use. Methods Clinicians contributing patients to the CorEvitas Rheumatoid Arthritis Registry were surveyed ...
Michael D. George, George Reed, Matthew D. Kearney, Peter F. Cronholm, Kevin Kane, Jeffrey R. Curtis, Dimitrios A. Pappas, Joel M. Kremer   +7 more
wiley   +1 more source