Results 31 to 40 of about 192,819 (168)

Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)R4E alleviates chronic pain in type 2 diabetic mice

PAIN Reports
. Introduction:. Pathological levels of methylglyoxal (MG), a reactive dicarbonyl product of glucose, contribute to major neurological complications associated with type II diabetes, including chronic neuropathic pain.
Paramita Basu, Diogo F. S. Santos, Nina Gakii, Margaret R. Gralinski, Ryan B. Griggs, Sebastian Brings, Thomas Fleming, Keiichiro Susuki, Bradley K. Taylor   +8 more
doaj   +1 more source

Pain and recovery following cesarean delivery in patients receiving an opioid-sparing pain regimen

AJOG Global Reports, 2023
Alex F. Peahl, MD, MSc, Alexander Hallway, BA, Brooke Kenney, MPH, Emma R. Lawrence, MD, MS, Roger Smith, MD, Chad M. Brummett, MD, Jennifer F. Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

The informational dysregulation framework of addiction (IDFA): an information-processing model of relapse in opioid use disorder

Frontiers in Psychiatry
Opioid use disorder is associated with high relapse risk and a persistent mismatch between intention and behavior. Contemporary neurobiological models have clarified the roles of reward learning, reinforcement, habit formation, salience attribution ...
Ovie Martin Albert, Ovie Martin Albert
doaj   +1 more source

The role of gonadal hormones in regulating opioid antinociception

Annals of Medicine
Opioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical studies have reported strong evidence for sex-related divergence regarding opioid analgesia.
Qi Xu, Lin Jin, LuYang Wang, YingYing Tang, Hui Wu, Qing Chen, LiHong Sun   +6 more
doaj   +1 more source

Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery [PDF]

Korean Journal of Anesthesiology
Background In this study, we aimed to investigate whether opioid-sparing anesthesia (OSA) reduces postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic gynecological surgery.
Sun Woo Nam, Sang-Hwan Do, Jung-Won Hwang, Insun Park, Insung Hwang, Hyo-Seok Na   +5 more
doaj   +1 more source

Naloxone distribution programs in the emergency department: A scoping review of the literature

Journal of the American College of Emergency Physicians Open
This scoping review summarized the literature regarding naloxone distribution from emergency departments (EDs) without a prescription. Our intention was to examine various naloxone distribution programs, their methodologies, and the level of ...
Mohan K. Sindhwani, Adam Friedman, Maureen O'Donnell, Donald Stader, Scott G. Weiner   +4 more
doaj   +1 more source

Pharmacokinetics of a continuous intravenous infusion of hydromorphone in healthy dogs

Frontiers in Veterinary Science
IntroductionDosing recommendations for hydromorphone intravenous constant rate infusion (IV CRI) are derived from simulations following IV bolus administration.
Candace Wimbish, Alex M. Lynch, Heather K. Knych, Yu Ueda, Kristen M. Messenger   +4 more
doaj   +1 more source

Opioid Metabolites [PDF]

Journal of Pain and Symptom Management, 2005
The metabolism of opioids closely relates to their chemical structure. Opioids are subject to O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I metabolites. By glucuronidation or sulfatation, phase-II metabolites are formed.
openaire   +2 more sources

Sources of strength: a process evaluation of a university-high school partnership to promote mental health protective factors

Frontiers in Public Health
The purpose of this manuscript was to discuss the implementation process of a student-led positive psychological and behavioral program (i.e., Sources of Strength) at a local high school to prevent opioid use and suicide behavior.
Duke Biber, Gina Brandenburg
doaj   +1 more source

Tracking and considerations on the therapeutic management of neuropathic pain in adult patients with sickle cell disease

BrJP
BACKGROUND AND OBJECTIVES: Sickle cell disease is considered the most common hereditary disorder in Brazil. The chronic pain resulting from some complications of sickle cell disease is still poorly understood, inadequately described, and under-researched.
Lais Costa Akcelrud Durão, Adriana do Carmo de Souza, Emanuele Pesenti, Maria Beatriz Campos, Daniel Benzecry Almeida   +4 more
doaj   +1 more source