Results 41 to 50 of about 269,209 (316)

Policies, adaptations, and ongoing challenges to naloxone, buprenorphine and nonprescription syringe access across four-states: Findings from an environmental scan and key informant interviews

Drug and Alcohol Dependence Reports
Background: As the US opioid-involved morbidity and mortality increase, uptake and implementation of evidence-based interventions remain key policy responses.
Anthony S. Floyd, Joseph Silcox, Gail Strickler, Thuong Nong, Malcolm Blough, Derek Bolivar, Megan Rabin, Jeffrey Bratberg, Adriane N. Irwin, Daniel M. Hartung, Ryan N. Hansen, Robert Bohler, Traci C. Green   +12 more
doaj   +1 more source

Analgesic Profile in Intensive Observation Room (Ruang Observasi Intensif/ ROI) Dr. Soetomo General Hospital Surabaya

JAI (Jurnal Anestesiologi Indonesia), 2023
Introduction: Pain is a condition that the majority of critical care patients will possibly suffer at some point during their stay in the intensive care unti (ICU). In both medical and surgical ICU patients, the incidence of considerable pain is still 50%
Bunga Priscilla Rotua Manurung, Maulydia Maulydia, Maftuchah Rochmanti, Nancy Margarita Rehatta   +3 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Developing a comprehensive inventory to define harm reduction housing

Harm Reduction Journal
Background The City of Boston has faced unprecedented challenges with substance use amidst changes to the illicit drug supply and increased visibility of homelessness.
Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green   +9 more
doaj   +1 more source

Efficacy of local infiltration anesthesia versus interscalene nerve blockade for total shoulder arthroplasty

JSES International, 2020
Background: Optimal modalities for pain control in shoulder arthroplasty are not yet established. Although regional nerve blockade has been a well-accepted modality, complications and rebound pain have led some surgeons to seek other pain control ...
Gary F. Updegrove, MD, Christopher M. Stauch, BSc, Padmavathi Ponnuru, PhD, Allen R. Kunselman, MA, April D. Armstrong, MD, MSc   +4 more
doaj   +1 more source

Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]

, 2013
There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine, Sarah Koutnik, Inka Regine Weingaertner, Koutnik, Sarah, Hermann Ammer, Ammer, Hermann   +5 more
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis

Annals of Surgery Open
Objective:. To assess the relationship between postoperative opioid consumption and frailty status. Background:. Physiologic reserve can be assessed through both chronologic age as well as measures of frailty.
Kyle R. Latack, MD, Ryan Howard, MD, Mark C. Bicket, MD, PhD, Samantha Cooley, MSW, Vidhya Gunaseelan, MBA, MS, MHA, Michael Englesbe, MD, Jennifer Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

Determining the impact of opioid substitution therapy upon mortality and recidivism among prisoners: a 22 year data linkage study [PDF]

, 2014
Foreword: Prisoners experience high rates of drug dependence, health problems and premature mortality. Without intervention, they often come into further contact with the criminal justice system, creating further health risk.
Natasa Gisev, Weatherburn, Don J., Burns, L., Lucy Burns, Louisa Degenhardt, Degenhardt, L., Gisev, Natasha, Mattick, R., Tony Butler, Weatherburn, Don, Kimber, J., Don Weatherburn, Kimber, Jo, Degenhardt, Louisa, Amy Gibson, Gisev, N., Larney, S ; https://orcid.org/, Gibson, Amy (R17420), Burns, Lucy, Larney, Sarah, Richard Mattick, Butler, Tony, Weatherburn, D., Dobbins, Tim, Gisev, N ; https://orcid.org/, Degenhardt, L ; https://orcid.org/, Tim Dobbins, Gibson, Amy, Weatherburn, D, Gibson, A., Mattick, RP, Larney, S., Gisev, Natasa, Jo Kimber, Dobbins, T ; https://orcid.org/, Mattick, Richard P., Dobbins, T., Sarah Larney, Kimber, J, Burns, L ; https://orcid.org/, Gibson, A ; https://orcid.org/, Butler, T ; https://orcid.org/, Dobbins, Timothy A., Mattick, Richard   +43 more
core  

Ancestral Vertebrate Complexity of the Opioid System

, 2015
The evolution of the opioid peptides and nociceptin/orphanin as well as their receptors has been difficult to resolve due to variable evolutionary rates.
Dan Larhammar, Görel Sundström, Larhammar, Dan,, Sundström, Görel,, Christina Bergqvist, Bergqvist, Christina A.,   +5 more
core   +1 more source