Results 51 to 60 of about 269,209 (316)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Opioid Use Patterns After Nonsurgical Management of Distal Radius Fractures: A Call for Opioid Stewardship

Journal of Hand Surgery Global Online
Purpose: While most opioid research focuses on postoperative use, limited data exist on prescribing patterns in nonsurgical management of common injuries such as distal radius fractures (DRFs).
Sina Ramtin, MD, Sara Khan, BS, Vijay Chhabra, BA, Wali Pirzada, BS, Mohammad Khak, MD, Asif M. Ilyas, MD, MBA   +5 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Study assessing the effectiveness of overdose prevention centers through evaluation research (SAFER): an overview of the study protocol

Harm Reduction Journal
More than one million people have died from drug overdose in the United States in the past 20 years. The overdose crisis started in the late 1990s with the proliferation of overdoses involving prescription opioids, transitioned to heroin-involved ...
Magdalena Cerdá, Bennett L. Allen, Alexandra B. Collins, Czarina N. Behrends, Michele Santacatterina, Victoria Jent, Brandon D. L. Marshall   +6 more
doaj   +1 more source

Short‐Term Outcomes of Robot‐Assisted Versus Laparoscopic Colectomy for Colon Cancer: A Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
This study compared short‐term outcomes of robot‐assisted versus laparoscopic colectomy for colon cancer using 1:1 propensity score matching. Among 218 matched pairs, robot‐assisted colectomy was associated with reduced blood loss, fewer conversions to open surgery, lower overall complication rates, and shorter hospital stays, despite longer operative ...
Akira Inoue, Yujiro Nishizawa, Yoshinori Kagawa, Masahiro Hashimoto, Shinya Kato, Yoshihiro Morimoto, Taishi Hata, Makoto Fujii, Masaaki Motoori, Kazumasa Fujitani   +9 more
wiley   +1 more source

A community‐driven approach to address substance use and create a Great Plains American Indian addiction and recovery research agenda

American Journal of Community Psychology, EarlyView.
Abstract Substance use, specifically opioid and methamphetamine use, is of increasing concern among American Indian (AI) populations in the Great Plains. This community‐driven participatory study investigated the impacts of substance use and community‐defined needs in treating addiction.
Brynn Luger, Anna Kihlström, Brinda Sivaramakrishnan, Allison Kelliher, Frankie Kropp, Carmen Rosa, T. John Winhusen, Donald Warne, the CTN0129 participating Tribal communities   +8 more
wiley   +1 more source

Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)R4E alleviates chronic pain in type 2 diabetic mice

PAIN Reports
. Introduction:. Pathological levels of methylglyoxal (MG), a reactive dicarbonyl product of glucose, contribute to major neurological complications associated with type II diabetes, including chronic neuropathic pain.
Paramita Basu, Diogo F. S. Santos, Nina Gakii, Margaret R. Gralinski, Ryan B. Griggs, Sebastian Brings, Thomas Fleming, Keiichiro Susuki, Bradley K. Taylor   +8 more
doaj   +1 more source

Online collection of meeting minutes of the Kansas Prescription Drug and Opioid Advisory Committee's committees, subcommittees and other afiliated groups, 2015-2018.

, 2015
Kansas Prescription Drug and Opioid Advisory Committee and subcommittees and other groups: Diagrams (2 pages) Kansas Prescription Drug and Opioid Advisory Committee.
Kansas Prescription Drug and Opioid Advisory Committee
core  

How opioid prescribing policies influence primary care clinicians’ treatment decisions and conversations with patients with chronic pain

, 2021
OBJECTIVE: The 2016 Centers for Disease Control and Prevention guideline for prescribing opioids for chronic pain aimed to assist primary care clinicians in safely and effectively prescribing opioids for chronic noncancer pain. Individual states, payers,
Harle, Christopher A., Mazurenko, Olena, Danielson, Elizabeth C., Militello, Laura, Downs, Sarah M.   +4 more
core   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source