Results 61 to 70 of about 313,201 (307)

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Policies, adaptations, and ongoing challenges to naloxone, buprenorphine and nonprescription syringe access across four-states: Findings from an environmental scan and key informant interviews

Drug and Alcohol Dependence Reports
Background: As the US opioid-involved morbidity and mortality increase, uptake and implementation of evidence-based interventions remain key policy responses.
Anthony S. Floyd, Joseph Silcox, Gail Strickler, Thuong Nong, Malcolm Blough, Derek Bolivar, Megan Rabin, Jeffrey Bratberg, Adriane N. Irwin, Daniel M. Hartung, Ryan N. Hansen, Robert Bohler, Traci C. Green   +12 more
doaj   +1 more source

Efficacy of local infiltration anesthesia versus interscalene nerve blockade for total shoulder arthroplasty

JSES International, 2020
Background: Optimal modalities for pain control in shoulder arthroplasty are not yet established. Although regional nerve blockade has been a well-accepted modality, complications and rebound pain have led some surgeons to seek other pain control ...
Gary F. Updegrove, MD, Christopher M. Stauch, BSc, Padmavathi Ponnuru, PhD, Allen R. Kunselman, MA, April D. Armstrong, MD, MSc   +4 more
doaj   +1 more source

Impact of opioid-induced constipation on opioid substitution therapy management: the patient perspective.

, 2021
Background: Although opioid-induced bowel dysfunction is a well-known and frequent adverse event correlated with opioids, it is scarcely investigated in patients on opioid substitution treatment (OST) and no standard of care is currently available for ...
Vivek Banerji, Hall, Genevieve, Fabio Lugoboni, Banerji, Vivek, Genevieve Hall, Lugoboni, Fabio   +5 more
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Opioid Use Patterns After Nonsurgical Management of Distal Radius Fractures: A Call for Opioid Stewardship

Journal of Hand Surgery Global Online
Purpose: While most opioid research focuses on postoperative use, limited data exist on prescribing patterns in nonsurgical management of common injuries such as distal radius fractures (DRFs).
Sina Ramtin, MD, Sara Khan, BS, Vijay Chhabra, BA, Wali Pirzada, BS, Mohammad Khak, MD, Asif M. Ilyas, MD, MBA   +5 more
doaj   +1 more source

Innovative Approach Reveals How Receptors Control G Protein State Equilibria

Advanced Science, EarlyView.
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean‐Philippe Pin   +12 more
wiley   +1 more source

qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness

Advanced Science, EarlyView.
In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang, Ziyan Zhang, Swee Hong Ng, Haipeng Gong   +3 more
wiley   +1 more source

Measurement of opioid misuse in the general Mexican population: Encodat 2025

Salud Pública de México
Objective. To examine the prevalence of categorical self-reported opioid misuse and compare it to a post hoc corrected indicator in the general Mexican population. Materials and methods.
Andrés Sánchez-Pájaro, Alan Reyes-García, Ariadne Rivera-Aguirre, María José Rivero-Treviño, Silvia L Cruz, Miguel Ángel López-Brambila, Daniel Pech-Puebla, Magdalena Cerdá   +7 more
doaj   +1 more source