Results 61 to 70 of about 269,209 (316)

Letter on Rockett's et al., manuscript: Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis

EClinicalMedicine, 2021
Julian Santaella-Tenorio, Tarlise Townsend, Noa Krawczyk, David Frank, Samuel R. Friedman   +4 more
doaj   +1 more source

Impact of opioid-induced constipation on opioid substitution therapy management: the patient perspective.

, 2021
Background: Although opioid-induced bowel dysfunction is a well-known and frequent adverse event correlated with opioids, it is scarcely investigated in patients on opioid substitution treatment (OST) and no standard of care is currently available for ...
Vivek Banerji, Hall, Genevieve, Fabio Lugoboni, Banerji, Vivek, Genevieve Hall, Lugoboni, Fabio   +5 more
core   +1 more source

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Pain and recovery following cesarean delivery in patients receiving an opioid-sparing pain regimen

AJOG Global Reports, 2023
Alex F. Peahl, MD, MSc, Alexander Hallway, BA, Brooke Kenney, MPH, Emma R. Lawrence, MD, MS, Roger Smith, MD, Chad M. Brummett, MD, Jennifer F. Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

Nontobacco Nicotine Dependence Is Associated With Perioperative Complications and Repeat Surgery After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To compare perioperative complications and revision surgery rates between following primary rotator cuff repair among patients with nontobacco nicotine dependence (NTND), no nicotine dependence, and traditional tobacco‐related nicotine dependence.
Samuel A. Florentino, Alexander N. Berk, Logan M. Good, Jeremy M. Adelstein, Robert J. Wetzel, George Ochenjele, Joshua K. Napora   +6 more
wiley   +1 more source

Stress-evoked opioid release inhibits pain in major depressive disorder

, 2008
To determine whether stress-evoked release of endogenous opioids might account for hypoalgesia in major depressive disorder (MDD), the μ-opioid antagonist naltrexone (50 mg) or placebo was administered double-blind to 24 participants with MDD and to 31 ...
Frew, A.K., Drummond, P.D.
core  

Editorial Commentary: Tobacco or Not—All Nicotine Products Negatively Impact Rotator Cuff Surgery

Arthroscopy, EarlyView.
Abstract Rotator cuff repair is one of the most common elective orthopaedic surgeries performed; however, failure rates have been reported to range from 10% to 94% depending on the tear characteristics and other patient risk factors. One of the most common risk factors for failure is tobacco use.
Justin J. Ernat
wiley   +1 more source

Kappa Opioid Regulation of Stress-Related Behavior

, 2010
Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression.
Harshberger, Erin
core  

Editorial Commentary: The Pericapsular Nerve Group Block in Hip Arthroscopy: Not a Miracle—But Ignoring It Is No Longer an Option

Arthroscopy, EarlyView.
Abstract Postoperative pain control remains a central determinant of discharge readiness, patient satisfaction, and opioid exposure after hip arthroscopy. Even modest improvements in early analgesia can meaningfully influence recovery pathways.
Alexander Zimmerer
wiley   +1 more source