Results 71 to 80 of about 313,201 (307)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Letter on Rockett's et al., manuscript: Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis

EClinicalMedicine, 2021
Julian Santaella-Tenorio, Tarlise Townsend, Noa Krawczyk, David Frank, Samuel R. Friedman   +4 more
doaj   +1 more source

Study assessing the effectiveness of overdose prevention centers through evaluation research (SAFER): an overview of the study protocol

Harm Reduction Journal
More than one million people have died from drug overdose in the United States in the past 20 years. The overdose crisis started in the late 1990s with the proliferation of overdoses involving prescription opioids, transitioned to heroin-involved ...
Magdalena Cerdá, Bennett L. Allen, Alexandra B. Collins, Czarina N. Behrends, Michele Santacatterina, Victoria Jent, Brandon D. L. Marshall   +6 more
doaj   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Personality and attention bias in adults with a history of childhood trauma, and attenuating effects of mu-opioid agonist buprenorphine on attention bias [PDF]

, 2011
The current study compared personality characteristics and cognitive functioning (specifically, attentional bias) in a sample of adults who had experienced childhood trauma (the Trauma group) and a matched healthy control group.
Christ, Bjorn U
core   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Pain and recovery following cesarean delivery in patients receiving an opioid-sparing pain regimen

AJOG Global Reports, 2023
Alex F. Peahl, MD, MSc, Alexander Hallway, BA, Brooke Kenney, MPH, Emma R. Lawrence, MD, MS, Roger Smith, MD, Chad M. Brummett, MD, Jennifer F. Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)R4E alleviates chronic pain in type 2 diabetic mice

PAIN Reports
. Introduction:. Pathological levels of methylglyoxal (MG), a reactive dicarbonyl product of glucose, contribute to major neurological complications associated with type II diabetes, including chronic neuropathic pain.
Paramita Basu, Diogo F. S. Santos, Nina Gakii, Margaret R. Gralinski, Ryan B. Griggs, Sebastian Brings, Thomas Fleming, Keiichiro Susuki, Bradley K. Taylor   +8 more
doaj   +1 more source

Small Intestinal Bacterial Overgrowth Following Gastrointestinal Cancer Surgery: Current Evidence and Future Perspectives

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Small intestinal bacterial overgrowth (SIBO) has recently gained increasing attention as a potential cause of postoperative gastrointestinal symptoms following gastrointestinal cancer surgery. Surgical procedures can disrupt normal gastrointestinal physiology through anatomical reconstruction, impaired motility, reduced gastric acid secretion,
Toru Aoyama, Haruhiko Cho, Takaki Yoshikawa   +2 more
wiley   +1 more source

Emergence of synthetic drugs in South America: insights from Brazil, Chile, and Colombia

Harm Reduction Journal
Background The illicit drug landscape in South America is going through a major shift. The appearance of Tusi (or “pink cocaine”), a mixture often containing ketamine and MDMA, along with the growing presence of synthetic opioids like fentanyl and ...
Ignacio Bórquez, Bruno Pantaleão, Gabriela Brogim, Ana Paula da Cunha, Noa Krawczyk, Francisco I. Bastos   +5 more
doaj   +1 more source