Results 71 to 80 of about 303,816 (301)

Study assessing the effectiveness of overdose prevention centers through evaluation research (SAFER): an overview of the study protocol

Harm Reduction Journal
More than one million people have died from drug overdose in the United States in the past 20 years. The overdose crisis started in the late 1990s with the proliferation of overdoses involving prescription opioids, transitioned to heroin-involved ...
Magdalena Cerdá, Bennett L. Allen, Alexandra B. Collins, Czarina N. Behrends, Michele Santacatterina, Victoria Jent, Brandon D. L. Marshall   +6 more
doaj   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Letter on Rockett's et al., manuscript: Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis

EClinicalMedicine, 2021
Julian Santaella-Tenorio, Tarlise Townsend, Noa Krawczyk, David Frank, Samuel R. Friedman   +4 more
doaj   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Pain and recovery following cesarean delivery in patients receiving an opioid-sparing pain regimen

AJOG Global Reports, 2023
Alex F. Peahl, MD, MSc, Alexander Hallway, BA, Brooke Kenney, MPH, Emma R. Lawrence, MD, MS, Roger Smith, MD, Chad M. Brummett, MD, Jennifer F. Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

Emergence of synthetic drugs in South America: insights from Brazil, Chile, and Colombia

Harm Reduction Journal
Background The illicit drug landscape in South America is going through a major shift. The appearance of Tusi (or “pink cocaine”), a mixture often containing ketamine and MDMA, along with the growing presence of synthetic opioids like fentanyl and ...
Ignacio Bórquez, Bruno Pantaleão, Gabriela Brogim, Ana Paula da Cunha, Noa Krawczyk, Francisco I. Bastos   +5 more
doaj   +1 more source

Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)R4E alleviates chronic pain in type 2 diabetic mice

PAIN Reports
. Introduction:. Pathological levels of methylglyoxal (MG), a reactive dicarbonyl product of glucose, contribute to major neurological complications associated with type II diabetes, including chronic neuropathic pain.
Paramita Basu, Diogo F. S. Santos, Nina Gakii, Margaret R. Gralinski, Ryan B. Griggs, Sebastian Brings, Thomas Fleming, Keiichiro Susuki, Bradley K. Taylor   +8 more
doaj   +1 more source

Predicting Opioid Epidemic by Using Twitter Data [PDF]

, 2018
Opioid crisis was declared as a public health emergency in 2017 by the President of USA. According to the Centers for Disease Control and Prevention, more than 91 Americans die every day from an opioid overdose.
Rendon, David Campo, Wu, Yubao, Skums, Pavel, Zelikovsky, Alex, Liao, Xueting   +4 more
core  

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

The informational dysregulation framework of addiction (IDFA): an information-processing model of relapse in opioid use disorder

Frontiers in Psychiatry
Opioid use disorder is associated with high relapse risk and a persistent mismatch between intention and behavior. Contemporary neurobiological models have clarified the roles of reward learning, reinforcement, habit formation, salience attribution ...
Ovie Martin Albert, Ovie Martin Albert
doaj   +1 more source