Results 1 to 10 of about 51,765 (292)

The relationship between methadone dosage and plasma level changes with aging in methadone maintenance treatment (MMT) patients [PDF]

Substance Abuse Treatment, Prevention, and Policy
Background As aging is associated with physiological changes, patients in methadone maintenance treatment (MMT) may require an adequate methadone dose adjustment.
Anat Sason, Miriam Adelson, Shaul Schreiber, Einat Peles   +3 more
doaj   +2 more sources

Intraoperative Low-Dose Methadone for Pediatric Posterior Spinal Fusion: A Single-Center Retrospective Cohort Study [PDF]

Children
Background: Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis causes significant postoperative pain and high opioid requirements. Methadone, with dual μ- and κ-opioid agonism and NMDA antagonism, provides long-acting analgesia and may ...
Roshni Cheema, Kristina Boyd, Mihaela Visoiu, Hsing-Hua Sylvia Lin, Scott E. Licata, Ruth Ressler, Vishali Veeramreddy, Shraddha Sriram, Selena Rashid, Senthilkumar Sadhasivam, Paul Hoffmann   +10 more
doaj   +2 more sources

Patient experiences of methadone treatment changes during the first wave of COVID-19: a national community-driven survey

Harm Reduction Journal, 2023
Background During COVID-19, the Substance Abuse and Mental Health Services Administration (SAMHSA) allowed Methadone Maintenance Treatment (MMT) programs to relax in-person MMT requirements to reduce COVID-19 exposure.
Sarah Brothers, Adam Palayew, Caty Simon, Abby Coulter, Knina Strichartz, Nick Voyles, Louise Vincent   +6 more
doaj   +1 more source

Interest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons.

PLoS ONE, 2022
HIV incidence continues to increase in Eastern Europe and Central Asia (EECA), in large part due to non-sterile injection drug use, especially within prisons. Therefore, medication-assisted therapy with opioid agonists is an evidence-based HIV-prevention
Amanda R Liberman, Daniel J Bromberg, Taylor Litz, Ainura Kurmanalieva, Samy Galvez, Julia Rozanova, Lyu Azbel, Jaimie P Meyer, Frederick L Altice   +8 more
doaj   +1 more source

Methadone is methadone

Canadian Family Physician, 2021
As a pharmacist who has been dispensing methadone for more than 20 years to patients in and out of Ontario provincial jails, I read the article by Raski et al in the November issue[1][1] with interest (and gratitude to one of the doctors on our team, who thoughtfully clipped this article out of ...
openaire   +2 more sources

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients. [PDF]

PLoS Genetics, 2016
Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients.
Hsin-Chou Yang, Shih-Kai Chu, Chieh-Liang Huang, Hsiang-Wei Kuo, Sheng-Chang Wang, Sheng-Wen Liu, Ing-Kang Ho, Yu-Li Liu   +7 more
doaj   +1 more source

Psychopathology and urine toxicology in methadone patients

Mental Illness, 2015
Several studies reported high rates of psychiatric commorbidity among methadone patients. We examined the relationships of measures of psychopathology to outcomes of screening urine tests for cocaine, opiates, and benzodiazepines in a sample of 56 ...
Gamal Sadek, Zack Cernovsky, Simon Chiu
doaj   +1 more source

The nature of methadone diversion in England: a Merseyside case study

Harm Reduction Journal, 2012
Background Methadone maintenance treatment (MMT) is a key element in treatment for opiate addiction; however concerns about the diversion of methadone remain. More current empirical data on methadone diversion are required. This research investigated the
Duffy Paul, Baldwin Helen
doaj   +1 more source

Toward precision prescribing for methadone: Determinants of methadone deposition.

PLoS ONE, 2020
BackgroundDespite the World Health Organization listing methadone as an essential medication, effective dose selection is challenging, especially in racial and ethnic minority populations.
Andrew H Talal, Yuxin Ding, Charles S Venuto, Lindsay M Chakan, Anthony McLeod, Arpan Dharia, Gene D Morse, Lawrence S Brown, Marianthi Markatou, Evan D Kharasch   +9 more
doaj   +1 more source

d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i

Scientific Reports, 2021
The search continues for improved therapy for acute lymphoblastic leukemia (aLL), the most common malignancy in children. Recently, d,l-methadone was put forth as sensitizer for aLL chemotherapy.
JungKwon Lee, Jesusa L. Rosales, Hee-Guk Byun, Ki-Young Lee   +3 more
doaj   +1 more source