Results 1 to 10 of about 41,381 (118)

Patient experiences of methadone treatment changes during the first wave of COVID-19: a national community-driven survey

Harm Reduction Journal, 2023
Background During COVID-19, the Substance Abuse and Mental Health Services Administration (SAMHSA) allowed Methadone Maintenance Treatment (MMT) programs to relax in-person MMT requirements to reduce COVID-19 exposure.
Sarah Brothers, Adam Palayew, Caty Simon, Abby Coulter, Knina Strichartz, Nick Voyles, Louise Vincent   +6 more
doaj   +1 more source

Interest without uptake: A mixed-methods analysis of methadone utilization in Kyrgyz prisons.

PLoS ONE, 2022
HIV incidence continues to increase in Eastern Europe and Central Asia (EECA), in large part due to non-sterile injection drug use, especially within prisons. Therefore, medication-assisted therapy with opioid agonists is an evidence-based HIV-prevention
Amanda R Liberman, Daniel J Bromberg, Taylor Litz, Ainura Kurmanalieva, Samy Galvez, Julia Rozanova, Lyu Azbel, Jaimie P Meyer, Frederick L Altice   +8 more
doaj   +1 more source

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients. [PDF]

PLoS Genetics, 2016
Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients.
Hsin-Chou Yang, Shih-Kai Chu, Chieh-Liang Huang, Hsiang-Wei Kuo, Sheng-Chang Wang, Sheng-Wen Liu, Ing-Kang Ho, Yu-Li Liu   +7 more
doaj   +1 more source

The nature of methadone diversion in England: a Merseyside case study

Harm Reduction Journal, 2012
Background Methadone maintenance treatment (MMT) is a key element in treatment for opiate addiction; however concerns about the diversion of methadone remain. More current empirical data on methadone diversion are required. This research investigated the
Duffy Paul, Baldwin Helen
doaj   +1 more source

d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i

Scientific Reports, 2021
The search continues for improved therapy for acute lymphoblastic leukemia (aLL), the most common malignancy in children. Recently, d,l-methadone was put forth as sensitizer for aLL chemotherapy.
JungKwon Lee, Jesusa L. Rosales, Hee-Guk Byun, Ki-Young Lee   +3 more
doaj   +1 more source

Psychopathology and urine toxicology in methadone patients

Mental Illness, 2015
Several studies reported high rates of psychiatric commorbidity among methadone patients. We examined the relationships of measures of psychopathology to outcomes of screening urine tests for cocaine, opiates, and benzodiazepines in a sample of 56 ...
Gamal Sadek, Zack Cernovsky, Simon Chiu
doaj   +1 more source

Barriers to retention in methadone maintenance therapy among people who inject drugs in Bangkok, Thailand: a mixed-methods study

Harm Reduction Journal, 2017
Background Methadone maintenance therapy (MMT) is a mainstay for treating opioid use disorder and preventing and managing HIV among people who inject drugs (PWID).
Kanna Hayashi, Lianping Ti, Prempreeda Pramoj Na Ayutthaya, Paisan Suwannawong, Karyn Kaplan, Will Small, Thomas Kerr   +6 more
doaj   +1 more source

Toward precision prescribing for methadone: Determinants of methadone deposition.

PLoS ONE, 2020
BackgroundDespite the World Health Organization listing methadone as an essential medication, effective dose selection is challenging, especially in racial and ethnic minority populations.
Andrew H Talal, Yuxin Ding, Charles S Venuto, Lindsay M Chakan, Anthony McLeod, Arpan Dharia, Gene D Morse, Lawrence S Brown, Marianthi Markatou, Evan D Kharasch   +9 more
doaj   +1 more source

The Effect of CYP2B6, CYP2D6, and CYP3A4 Alleles on Methadone Binding: A Molecular Docking Study

Journal of Chemistry, 2013
Current methadone maintenance therapy (MMT) is yet to ensure 100% successful treatment as the optimum dosage has yet to be determined. Overdose leads to death while lower dose causes the opioid withdrawal effect.
Nik Nur Syazana Bt Nik Mohamed Kamal, Theam Soon Lim, Gee Jun Tye, Rusli Ismail, Yee Siew Choong   +4 more
doaj   +1 more source

Estimate cost of providing methadone maintenance treatment at a methadone clinic in Nairobi Kenya: direct costs

The Pan African Medical Journal, 2021
Methadone maintenance treatment is reported as cost-effective in treatment of opioid use disorder. Estimated cost of providing methadone varies widely in different regions but there is no data regarding cost of methadone treatment in Kenya.
Brenda Mogaka1, Sarah Kanana Kiburi, Mirriam Mutinda, Maxwel Kendagor   +3 more
doaj   +1 more source