Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?. [PDF]
Methadone is increasingly involved in drug overdose cases and the molecular actions of the drug in vivo are largely unknown requiring elucidation. This study set out to examine the relationship between methadone toxicity and CYP2B6 and mu (μ) opioid ...
Bunten, Hannah
core +9 more sources
The role of concomitant drugs in the aetiology of fatal heroin- and methadone- related overdose [PDF]
, 2008 Heroin and methadone poisoning are significant causes of death of young people in the United Kingdom. In a high proportion of these fatalities concomitant substances are also detected.
Oliver, Phillip
core +6 more sources
Maternal methadone use in pregnancy : factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources [PDF]
, 2009 The objectives of this study were to investigate factors associated with the development of neonatal abstinence syndrome (NAS) and to assess the implications for healthcare resources of infants born to drug-misusing women. Design.
Hepburn, M. +3 more
core +4 more sources
Canadian Family Physician, 2021 As a pharmacist who has been dispensing methadone for more than 20 years to patients in and out of Ontario provincial jails, I read the article by Raski et al in the November issue[1][1] with interest (and gratitude to one of the doctors on our team, who thoughtfully clipped this article out of ...
openaire +2 more sources
Stereoselective methadone disposition after administration of racemic methadone to anesthetized Shetland ponies assessed by capillary electrophoresis [PDF]
, 2021 The enantioselectivity of the pharmacokinetics of methadone was investigated in anesthetized Shetland ponies after a single intravenous (0.5 mg/kg methadone hydrochloride; n = 6) or constant rate infusion (0.25 mg/kg bolus followed by 0.25 mg/kg/h ...
Thormann, Wolfgang, +19 more
core +2 more sources
Higher methadone dose reduces risky drug injecting behaviours among methadone clients in Myanmar
Emerging Trends in Drugs, Addictions, and Health, 2021 Background: HIV prevalence rate among people who inject drugs (PWIDs) in Myanmar is marginally high (34.9%). HIV transmission can be reduced and prevented through harm reduction programs such as methadone maintenance treatment (MMT) and needle syringe ...
Sun Tun, B. Vicknasingam, Darshan Singh
doaj +1 more source
Australian and New Zealand Journal of Public Health, 2003 Objective: To describe methadone injectors and the risk practices associated with injecting methadone in New South Wales, Australia. To assess the impact on injecting drug use and risk behaviour of the withdrawal of methadone injecting equipment from ...
Max Hopwood +5 more
doaj +1 more source
Life, 2022 The aim of this review is to summarize the current knowledge of low-dose methadone treatment in palliative cancer care. In Sweden, methadone is quite common in specialized palliative care, where almost a tenth of patients are prescribed this drug ...
Per Fürst
doaj +1 more source
Safe storage of methadone in the home - an audit of the effectiveness of safety information giving
Harm Reduction Journal, 2005 Background Accidental poisoning by methadone occurs, particularly as a result of children ingesting a parent's methadone. Health care professionals have a responsibility to provide information and guidance to methadone users on safe storage of methadone.
McAuley Rosanna +2 more
doaj +1 more source
Is the promise of methadone Kenya's solution to managing HIV and addiction? A mixed-method mathematical modelling and qualitative study. [PDF]
, 2015 BACKGROUND AND OBJECTIVES: Promoted globally as an evidence-based intervention in the prevention of HIV and treatment of heroin addiction among people who inject drugs (PWID), opioid substitution treatment (OST) can help control emerging HIV epidemics ...
Guise, Andy +9 more
core +1 more source