Results 31 to 40 of about 58,733 (293)

Methadone treatment for opiate dependent patients in general practice and specialist clinic settings : outcomes at one-year follow-up [PDF]

, 2004
Few studies have investigated methadone maintenance treatment of opiate dependent patients in primary health care settings compared to specialist clinic settings.
Petitjean Gottfried, Sylvie
core   +1 more source

CYP2D6‐Guided Opioid Therapy for Chronic Pain: A Multi‐Center Pragmatic Randomized Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
The analgesic effectiveness of several opioids depends on CYP2D6‐mediated metabolism to more active opioid receptor agonists. CYP2D6 activity is impacted by genetic variability and medications that inhibit CYP2D6. We conducted a pragmatic, multi‐center, randomized, controlled trial to determine whether CYP2D6‐guided opioid prescribing improves chronic ...
Todd C. Skaar, Rachel A. Myers, Roger B. Fillingim, John T. Callaghan, Kerri L. Cavanaugh, Hrishikesh Chakraborty, Jordan F. Baye, Emily J. Cicali, Michael T. Eadon, Erica N. Elwood, Elizabeth C. Harris, Lindsay J. Hines, Khoa A. Nguyen, Michelle A. Ramos, Marc Rosenman, Azita Sadeghpour, Saskia Shuman, Rajbir Singh, Emma M. Tillman, Christina M. Wyatt, Carol R. Horowitz, Deepak Voora, Lori A. Orlando, Josh F. Peterson, Larisa H. Cavallari, Julie A. Johnson, Paul R. Dexter, on behalf of the IGNITE Pragmatic Trials Network, L Orlando, D Voora, C Horowitz, C Horowitz, N Calman, T Skaar, T Skaar, P Dexter, T Skaar, P Dexter, J Johnson, L Cavallari, J Johnson, L Cavallari, J Johnson, L Cavallari, K Blake, K Blake, K Blake, J Peterson, J Peterson, K Cavanaugh, R Singh, R Singh, L Hines, C Wyatt, H Chakraborty, Christina Wyatt, Geoff Ginsburg, Kady‐Ann Steen‐Burrell, Bhargav Adagarla, Sarah George, Beth Harris, Jaclyn Holland, Yashika Johnson, Phyllis Kennel, Kristen Linney, Rania Metry, Rachel Myers, Wanda Parker, Gayle Passmore, Carol Pereira, Teji Rakhra‐Burris, Ryanne Wu, Ruth Lehan, Tyffany Locklear, Carol Horowitz, Michelle Ramos, Sabrina Clermont, Bart Ferket, Kenneth Fifer, Diane Hauser, Joseph Kannry, James Murrough, Aniwaa Owusu Obeng, Janet Seo, Tatiana Sabin, Nandini Shroff, Paul Dexter, Abi Colwell, Amy M. Breman, Zeruesenay Desta, Cathy Fulton, Jennelle C. Hodge, Sheryl Lynch, Jonathan Oliver, Victoria M. Pratt, Ross Robinson, Elizabeth Rowe, Jennifer Stuart, Emma Tillman, Ashley Vetor, Julie Johnson, Larisa Cavallari, Alexander Parker, Erica Elwood, Kathryn Blake, Emily Cicali, Kelsey Cook, Karam Diaby, Julio Duarte, Ben Duong, Karla Giron, Elizabeth Eddy, Julia Krutov, Carol Mathews, Haesuk Park, Robyn Nelson, Ryan Rhoden, Caroline Schlierle, Taylor Sullivan, Almut Winterstein, Kristen Wiisanen, Josh Peterson, Kerri Cavanaugh, Sara Van Driest, Sara Block, Jordan Baye, Michelle Benck, Chantel Bender, Sylvia Eluhu, Colette Free, Shane Gonnelly, Sarah Hedeen, Lindsay Hines, Steve Houtschilt, Michelle Liu, Salisha Marryshow, Nicole Neville, Natasha Petry, Sidd Pratap, Vernon Sherden, Kimberly Snell, Ana Tomescu, Megan Trietsch, James Walker, Deanna Web, Erin Whiting, Russell A. Wilke, Simona Volpi, Sarah Hutchison, Natalie Kucher, Ebony Madden, Jessica Reinach, Renee Rider, Ismail Safi, Ella Samer, Lori Orlando, Lani Banez, Lisa Bendz, Jackie Jordan, Ann McGee, Christina Nix, Lorraine Vergara, Tyler Colon, Aaishah Francis, Samantha Guagliardo, Najiba Khan, Camila Tan Lam, Michelle Sciarrino, Emma Maiman‐Stadtmauer, Sofia Medina‐Pardo, Ololade (Lola) Williams, Sheng Luo, Kevin Anstrom, Alicia Ellis, Stephen Ellis, Hwasoon Kim, Peter Merrill, Lilin She, Jennifer Shepherd, Saira Siddiqui, Jun Wen, Brittany Davis, John Howard, Alia Jamison, Lydia Joyner, Ellie Kiihne, Johnathan Oliver, Libbie Silverman, Jordan Sonneville Jennifer Stuart, Laurel Tokar, Neil Calman, Daviana Buck, Nicole Canchucaja Porshia Cook, Ariel Jacobs Danielle John, Mirta (Mimi) Milanes, Wambui Ngari, Megan Triestch, Abraham Garcia, Carol Gutierrez, Steven Houtschilt, Maria Lopez, Alan Mejia, Anaite Montes Bu, Deanna Webb, Sonja White, Ali Brewer, Brittni Deadrick, Alexis Meyer, Blair Svennes, Hana Al Alshaykh, Tala Basha, Asia Cobb, Brendon Cooper, Amanda Elchynski, Amanda Elsey, Anuksha Gotmare, Lauren Lemke, Arielle Nelson, Michael Read, Genevieve Rosier, Isabella Schultz, Chiara Chermont Spina, Joshua Terrell, Alexa Valko, Precious Williams, Tracy Leonard, David Smith, Marian Davis, Vincent Guerra, Jennifer Salo, Claudia Cartaya Torres, Jorge Valedon, Paola Nieves Viana, Jose Alonso, Jeffery Gainer, Morgan Howard, Fatoumata Kaba, Brianna Rivers, Liliana Serrano, Kimberly Vigal, ADeia Williams, Angelo Lazaro, Salisha Merryshow, Henry Ong, John Thomas Callaghan, Raheleh Rahimi Darabad, Daniel Getu, Katherine Huber, Judive Jocelyn, Robin Morman Li, Rosalena Muckle, Brandi Plunkett, Siegfried Schmidt, Evgenia Teal, Petra Townsend, Joshua R. Wellington   +255 more
wiley   +1 more source

Perceived barriers to methadone maintenance treatment among Iranian opioid users

International Journal for Equity in Health, 2018
Background Opioid use is a severe problem in Iran. Despite methadone maintenance treatment (MMT) programs being one of the most important treatment strategies for reducing individual and public harms associated with opioid use, a large proportion of ...
Maryam Khazaee-Pool, Maryam Moeeni, Koen Ponnet, Arezoo Fallahi, Leila Jahangiri, Tahereh Pashaei   +5 more
doaj   +1 more source

Intraoperative Methadone Use in Patients Undergoing Minimally Invasive Colorectal Surgical Procedures

World Journal of Colorectal Surgery, 2023
Background: Postoperative pain control is an important aspect in the recovery of patients. Recent literature suggests that the extended half-life of methadone may reduce overall opioid utilization in postoperative patients.
Nathan S Kau
doaj   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

Confidence in providing methadone maintenance treatment of primary care providers in Vietnam

Addiction Science & Clinical Practice
Background Delivering methadone treatment in community health facilities by primary care providers is a task-shifting strategy to expand access to drug use treatment, especially in rural mountainous areas.
Bich Diep Nguyen, Li Li, Chunqing Lin, Thu Trang Nguyen, Steven Shoptaw, Minh Giang Le   +5 more
doaj   +1 more source

Intraoperative Methadone Versus Non-Methadone Analgesia in Pediatric Cardiac Surgery: A Retrospective Cohort Study

Children
Introduction: Methadone is an opioid-sparing opioid and it is increasingly used in children undergoing surgery due to its beneficial effects on postoperative pain scores, decreased opioid requirements, and fewer adverse effects compared to other opioids.
Brian Blasiole, Danielle R. Lavage, Hsing-Hua Sylvia Lin, Scott E. Licata, Sahana Sivam, Inesh Sivam, Laura M. Le, Senthilkumar Sadhasivam   +7 more
doaj   +1 more source

Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

CPT: Pharmacometrics & Systems Pharmacology, 2021
Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined.
Blessed W. Aruldhas, Sara K. Quinney, Brian R. Overholser, Michael A. Heathman, Andrea R. Masters, Reynold C. Ly, Hongyu Gao, Senthil Packiasabapathy, Senthilkumar Sadhasivam   +8 more
doaj   +1 more source

Intra‐Individual Variability of Blood and Urinary Steroid Markers and the Response to Codeine Intake in Healthy Men and Women

Drug Testing and Analysis, EarlyView.
Short‐term codeine administration (1–3 days) caused individual alterations in Athlete Biological Passport steroid markers, including elevated urinary T/E ratios and decreased serum testosterone concentrations below individual thresholds, despite no significant changes at the group level.
Alexander Andersson, Basam Yousif, Anton Pohanka, Annica Börjesson, Mikael Lehtihet, Lena Ekström   +5 more
wiley   +1 more source

The Role of Nitrous Oxide (“Laughing Gas”) in DUID Cases and Its Impact on Driving Fitness

Drug Testing and Analysis, EarlyView.
A total number of 39 cases of driving under the influence of nitrous oxide were investigated. Plasma concentrations of 0.22 to 17 mL/L (median:3.7 mL/L) were measured in blood samples withdrawn 38 to 144 min (median: 85 min) after control via Headspace‐GC–MS.
L. Lucuta, P. Stach, J. Hose, H. Andresen‐Streichert, M. Juebner   +4 more
wiley   +1 more source