Results 31 to 40 of about 51,637 (307)

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Confidence in providing methadone maintenance treatment of primary care providers in Vietnam

Addiction Science & Clinical Practice
Background Delivering methadone treatment in community health facilities by primary care providers is a task-shifting strategy to expand access to drug use treatment, especially in rural mountainous areas.
Bich Diep Nguyen, Li Li, Chunqing Lin, Thu Trang Nguyen, Steven Shoptaw, Minh Giang Le   +5 more
doaj   +1 more source

Rapid Methadone Metabolism in Opioid Use Disorder: A Case Report of Clinical Challenges and Individualized Treatment Approaches

Reports
Rapid methadone metabolism in patients with opioid use disorder could complicate methadone treatment. Toxicology screenings to monitor methadone levels may show negative for methadone, even with regular adherence to a regimen.
Farhana Nazmin, Jaskaran Singh, Narges Joshaghani, Elisio Go   +3 more
doaj   +1 more source

Effect of oxycodone vs. morphine as first‐line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Postoperative opioids, intended for short‐term analgesia, contribute to new persistent opioid use in 1%–7% of patients, adversely affecting outcomes. Oxycodone may carry higher risk than morphine, though long‐term data are limited.
Eward J. Melis, Johanna E. Vriezekolk, Frédérique H. C. Bollen, Dirk E. Schrander, Arnt F. A. Schellekens, Bart J. F. van den Bemt   +5 more
wiley   +1 more source

Liver transplant and hepatitis C in methadone maintenance therapy: a case report

Substance Abuse Treatment, Prevention, and Policy, 2007
Methadone maintenance therapy for the treatment of opioid dependence continues to carry a social stigma. Until recently, patients on methadone were not considered for liver transplantation.
Bourgeois James A, Craemer Elana, Lester Laura, Ransibrahmanakul Kanat, Prosser Colette C, Hancock Meredith M, Rossaro Lorenzo   +6 more
doaj   +1 more source

Methadone for Cancer Pain

, 2010
Pain is one of the most common and incapacitating symptoms experienced by patients with advanced cancer. Methadone is a potent opioid with strong affinity for the µ opioid receptor. In addition to being a potent µ opioid receptor ligand, methadone blocks
Eric E. Prommer
core   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist

Molecular Pain, 2016
Background Methadone is a unique µ-opioid receptor agonist. Although several researchers have insisted that the pharmacological effects of methadone are mediated through the blockade of NMDA receptor, the underlying mechanism by which methadone exerts ...
Seira Doi BS, Tomohisa Mori PhD, Naoki Uzawa MS, Takamichi Arima BA, Tomoyuki Takahashi BA, Masashi Uchida BS, Ayaka Yawata BA, Michiko Narita BS, Yasuhito Uezono PhD, Tsutomu Suzuki PhD, Minoru Narita PhD   +10 more
doaj   +1 more source

Opiate agonists and antagonists modulate taste perception in opiate-maintained, and recently detoxified subjects. [PDF]

, 2013
Heroin addicts consume large quantities of refined sugars. This study investigated the effect of opiate use and antagonism on sweet taste in opiate-maintained drug users and detoxified former chronic opiate users, using a within-subject design.
Green, Amy, Mullings, Emma L, Sharma, Ekta, Nutt, David J, Melichar, Jan K, O’Shea, Jacinta, Munafò, Marcus R., Bennett, Lisa, Donaldson, Lucy F., Nutt, David J., Donaldson, Lucy F, O'Shea, Jacinta, Munafò, Marcus R, Melichar, Jan K., Kaul, Arun   +14 more
core   +1 more source