Results 51 to 60 of about 51,637 (307)

Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

CPT: Pharmacometrics & Systems Pharmacology, 2021
Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined.
Blessed W. Aruldhas, Sara K. Quinney, Brian R. Overholser, Michael A. Heathman, Andrea R. Masters, Reynold C. Ly, Hongyu Gao, Senthil Packiasabapathy, Senthilkumar Sadhasivam   +8 more
doaj   +1 more source

Identification of Factors Contributing to Methadone-Induced Daytime Sleepiness in Cancer Patients and Proposal of the Conversion Ratio from Other Opioids to Oral Methadone: A Retrospective Cohort Study

Palliative Medicine Reports, 2023
Background: When methadone is used to treat cancer pain, the Japanese health insurance system recommends to determine the starting dose according to the equivalency conversion table based on the morphine-equivalent daily dose (MEDD) of prior opioids ...
Miho Takemura, Kazuyuki Niki, Yoshiaki Okamoto, Yoshinobu Matsuda, Makie Kohno, Mikiko Ueda   +5 more
doaj   +1 more source

Methadone’s Moment [PDF]

JAMA
This work discusses unfettering methadone from outdated regulations to empower patients to access treatment and advocate for methadone's expansion in their local communities by working with pharmacies and local health systems.
Incze, Michael A, Simon, Caty, Suen, Leslie W   +2 more
openaire   +3 more sources

Detection of Methadone, LAAM, and Their Metabolites by Methadone Immunoassays [PDF]

Journal of Analytical Toxicology, 1999
l-Alpha-acetylmethadol (LAAM) was recently approved as a substitute for methadone. LAAM, methadone, and their common metabolite, methadol, are extensively N-demethylated. The structural similarities of LAAM and its metabolites to methadone suggest that they may cross-react in methadone immunoassays.
M L, Cheever, G A, Armendariz, D E, Moody   +2 more
openaire   +2 more sources

Things We Do for No Reason™: Withholding opioids among patients with acute pain and opioid use disorder

Journal of Hospital Medicine, EarlyView.
Abstract Hospitalists care for patients with acute pain who have an opioid use disorder and require pain management. Hospitalists may withhold opioids for acute pain due to a variety of reasons. However, adequate pain management in patients with opioid use disorder, including with opioids, is the standard of care. This piece explains how to best manage
Anna‐Maria South, Susan L. Calcaterra, Marlene Martin   +2 more
wiley   +1 more source

Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice

Frontiers in Pharmacology, 2020
Analgesic efficacy of methadone in cancer and chronic non-cancer pains is greater than that of other opioids, probably because of its unique pharmacokinetics properties and also because it targets glutamatergic receptors in addition to µ-opioid receptors.
Valeria González, Teresa Pelissier, Victoria Cazanga, Alejandro Hernández, Luis Constandil, Luis Constandil   +5 more
doaj   +1 more source

Codeine and Metabolite Concentrations in the Breastfed Neonate

Pediatric Anesthesia, EarlyView.
ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley   +1 more source

Methadone Dosage and Plasma Levels, SNPs of OPRM1 Gene and Age of First Drug Use Were Associated With Outcomes of Methadone Maintenance Treatment

Frontiers in Genetics, 2018
Objective: To explore the association between methadone dosage, plasma drug concentration, SNPs of μ-opioid receptor gene (OPRM1), ATP-binding cassette subfamily B member 1 gene (ABCB1), and methadone maintenance treatment (MMT) response.Method: A total ...
Sufang Peng, Haifeng Jiang, Jiang Du, Shuxing Lin, Shujun Pan, Shunying Yu, Min Zhao, Min Zhao, Min Zhao   +8 more
doaj   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Optimizing methadone dose adjustment in patients with opioid use disorder

Frontiers in Psychiatry
IntroductionOpioid use disorder is a cause for concern globally. This study aimed to optimize methadone dose adjustments using mixed modeling and machine learning.MethodsThis retrospective study was conducted at Taichung Veterans General Hospital between
Po-Shen Liu, Teng-Yao Kuo, I-Chun Chen, I-Chun Chen, I-Chun Chen, Shu-Wua Lee, Ting-Gang Chang, Hou-Liang Chen, Jun-Peng Chen   +8 more
doaj   +1 more source