Results 21 to 30 of about 192,819 (168)

Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

Molecules, 2021
In this study, we aimed to design and synthesize novel molecules carrying both the thiazole and piperazine rings in their structures and to investigate their antinociceptive activity.
Nazlı Turan Yücel, Derya Osmaniye, Ümmühan Kandemir, Asaf Evrim Evren, Özgür Devrim Can, Ümide Demir Özkay   +5 more
doaj   +1 more source

Opioid Epidemics

SSRN Electronic Journal, 2019
In this paper, I propose an economic theory that addresses the epidemic character of opioid epidemics. I consider a community in which individuals are heterogenous with respect to the experience of chronic pain and susceptibility to addiction and live through two periods.
openaire   +5 more sources

Policies, adaptations, and ongoing challenges to naloxone, buprenorphine and nonprescription syringe access across four-states: Findings from an environmental scan and key informant interviews

Drug and Alcohol Dependence Reports
Background: As the US opioid-involved morbidity and mortality increase, uptake and implementation of evidence-based interventions remain key policy responses.
Anthony S. Floyd, Joseph Silcox, Gail Strickler, Thuong Nong, Malcolm Blough, Derek Bolivar, Megan Rabin, Jeffrey Bratberg, Adriane N. Irwin, Daniel M. Hartung, Ryan N. Hansen, Robert Bohler, Traci C. Green   +12 more
doaj   +1 more source

Efficacy of local infiltration anesthesia versus interscalene nerve blockade for total shoulder arthroplasty

JSES International, 2020
Background: Optimal modalities for pain control in shoulder arthroplasty are not yet established. Although regional nerve blockade has been a well-accepted modality, complications and rebound pain have led some surgeons to seek other pain control ...
Gary F. Updegrove, MD, Christopher M. Stauch, BSc, Padmavathi Ponnuru, PhD, Allen R. Kunselman, MA, April D. Armstrong, MD, MSc   +4 more
doaj   +1 more source

Developing a comprehensive inventory to define harm reduction housing

Harm Reduction Journal
Background The City of Boston has faced unprecedented challenges with substance use amidst changes to the illicit drug supply and increased visibility of homelessness.
Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green   +9 more
doaj   +1 more source

Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis

Annals of Surgery Open
Objective:. To assess the relationship between postoperative opioid consumption and frailty status. Background:. Physiologic reserve can be assessed through both chronologic age as well as measures of frailty.
Kyle R. Latack, MD, Ryan Howard, MD, Mark C. Bicket, MD, PhD, Samantha Cooley, MSW, Vidhya Gunaseelan, MBA, MS, MHA, Michael Englesbe, MD, Jennifer Waljee, MD, MPH, MS   +6 more
doaj   +1 more source

Opioid Use Patterns After Nonsurgical Management of Distal Radius Fractures: A Call for Opioid Stewardship

Journal of Hand Surgery Global Online
Purpose: While most opioid research focuses on postoperative use, limited data exist on prescribing patterns in nonsurgical management of common injuries such as distal radius fractures (DRFs).
Sina Ramtin, MD, Sara Khan, BS, Vijay Chhabra, BA, Wali Pirzada, BS, Mohammad Khak, MD, Asif M. Ilyas, MD, MBA   +5 more
doaj   +1 more source

Study assessing the effectiveness of overdose prevention centers through evaluation research (SAFER): an overview of the study protocol

Harm Reduction Journal
More than one million people have died from drug overdose in the United States in the past 20 years. The overdose crisis started in the late 1990s with the proliferation of overdoses involving prescription opioids, transitioned to heroin-involved ...
Magdalena Cerdá, Bennett L. Allen, Alexandra B. Collins, Czarina N. Behrends, Michele Santacatterina, Victoria Jent, Brandon D. L. Marshall   +6 more
doaj   +1 more source

Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study

Acta Pharmaceutica, 2022
A good therapeutic alliance is relevant for healthcare providers exposed to patients’ suffering, especially since patients and physicians may understand the painful experience differently.
Barrachina Jordi, Margarit César, Andreu Blanca, Zandonai Thomas, Ballester Pura, Muriel Javier, Cutillas Esperanza, Peiró Ana M.   +7 more
doaj   +1 more source

Letter on Rockett's et al., manuscript: Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis

EClinicalMedicine, 2021
Julian Santaella-Tenorio, Tarlise Townsend, Noa Krawczyk, David Frank, Samuel R. Friedman   +4 more
doaj   +1 more source