Results 21 to 30 of about 313,201 (307)
The Opioid-Tolerant Patient: Opioid Optimization [PDF]
The Journal of Arthroplasty, 2020 Chronic opioid use and abuse continue to plague our country despite efforts to curtail their use. Patients on chronic opioids (opioids tolerant) who undergo total joint arthroplasty have been clearly shown to have higher rates of complications, infection, and early revision compared to the opioid-naïve patients.
Padma, Gulur, Amanda H, Nelli
openaire +2 more sources
Naltrexone beyond Psychiatric Domain
Indian Journal of Medical Specialities, 2022 Naltrexone, an opioid receptor (OR) antagonist, at its standard doses, is a United States Federal Drug Administration-approved drug for opioid and alcohol use disorders.
Ashutosh Garg +2 more
doaj +1 more source
Opioids, opioids, opioids [PDF]
Nordic Studies on Alcohol and Drugs, 2018 Non peer ...
openaire +3 more sources
Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms
eLife, 2023 Opioids depress breathing by inhibition of interconnected respiratory nuclei in the pons and medulla. Mu opioid receptor (MOR) agonists directly hyperpolarize a population of neurons in the dorsolateral pons, particularly the Kölliker-Fuse (KF) nucleus ...
Jordan T Bateman, Erica S Levitt
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Cardiovascular disease is a risk factor for cognitive impairment. Evidence links both lower and higher concentration of the circulating opioid pro‐enkephalin A (PENK‐A) with stroke risk.
Samuel A. P. Short +7 more
doaj +1 more source
Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]
, 2012 Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas +7 more
core +1 more source
Molecules, 2021 In this study, we aimed to design and synthesize novel molecules carrying both the thiazole and piperazine rings in their structures and to investigate their antinociceptive activity.
Nazlı Turan Yücel +5 more
doaj +1 more source
The impact of stigma on people with opioid use disorder, opioid treatment, and policy.
, 2022 Illicit drug use disorders are the most stigmatised health conditions worldwide, and stigma acts as a meaningful barrier to treatment entry and treatment provision.
Lubman, Dan I +4 more
core +1 more source
Annals of MedicineBackground The Confederated Tribes of the Grand Ronde Community of Oregon began a Mobile Medication Unit (MMU) as part of their Great Circle Recovery Opioid Treatment Program (OTP) to address elevated rates of opioid use disorder (OUD) among American ...
Kim A. Hoffman +7 more
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source