Results 11 to 20 of about 65,278 (248)
Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Ammer, Hermann +2 more
core +7 more sources
Modeling Supports Combinatorial Effects Between Pharmacological and Non-Pharmacological Interventions to Prevent Opioid-Induced Cardiac Arrest. [PDF]
Clin Pharmacol TherFew studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Thrasher B +12 more
europepmc +2 more sources
Predicting pharmacy naloxone stocking and dispensing following a statewide standing order, Indiana 2016 [PDF]
, 2018 BACKGROUND: While naloxone, the overdose reversal medication, has been available for decades, factors associated with its availability through pharmacies remain unclear.
Agley, J.D. +8 more
core +1 more source
Pharmacy, 2022 Background: Opioid overdoses continue to be one of the most urgent public health priorities. In 2020, reported overdose deaths in the United States reached a high of over 93,000 cases. As the COVID-19 pandemic and opioid crisis continues to be addressed,
Jennifer Courtney +6 more
doaj +1 more source
Harm Reduction Journal, 2022 Background Expanding availability to naloxone is a core harm reduction strategy in efforts to address the opioid epidemic. In the US, state-level legislation is a prominent mechanism to expand naloxone availability through various venues, such as ...
Sean Grant, Rosanna Smart
doaj +1 more source
Preventive Medicine Reports, 2019 The rate of opioid misuse and overdose continues to increase in rural areas of the U.S. In response, access to naloxone hydrochloride (“naloxone”), an opioid antagonist used to reverse opioid overdose, has increased among both first responders and ...
Tess M. Kilwein +3 more
doaj +1 more source
Prehospital naloxone administration – what influences choice of dose and route of administration?
BMC Emergency Medicine, 2020 Background Amidst the ongoing opioid crisis there are debates regarding the optimal route of administration and dosages of naloxone. This applies both for lay people administration and emergency medical services, and in the development of new naloxone ...
Ida Tylleskar +6 more
doaj +1 more source
The Lancet Public Health, 2022 Summary: Background: The US overdose crisis is driven by fentanyl, heroin, and prescription opioids. One evidence-based policy response has been to broaden naloxone distribution, but how much naloxone a community would need to reduce the incidence of ...
Michael A Irvine, PhD +10 more
doaj +1 more source
Opiate users' knowledge about overdose prevention and naloxone in New York City: a focus group study
Harm Reduction Journal, 2006 Background Drug-induced and drug-related deaths have been increasing for the past decade throughout the US. In NYC, drug overdose accounts for nearly 900 deaths per year, a figure that exceeds the number of deaths each year from homicide.
Galea Sandro +3 more
doaj +1 more source
PLoS ONE, 2020 IntroductionOverdose is a leading cause of death in the United States, especially among people who inject drugs (PWID). Improving naloxone access and carrying among PWID may offset recent increases in overdose mortality associated with the influx of ...
Megan Buresh +5 more
doaj +1 more source