Results 71 to 80 of about 54,444 (297)

The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023
Background and Objectives: Studies have indicated that the chronic use of morphine can result in physical and psychological dependence. Morphine dependence is associated with several cellular and molecular alterations in the mesocorticolimbic system, and
Sahar Khalili Samani, Solmaz Khalifeh, Mehdi Vahiddastjerdi, Mandana Hassanzad, Afshin Kheradmand, Farzaneh Nazari Serenjeh   +5 more
doaj  

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Promoting Safe Opioid Disposal: Experimental Evidence on Behavioral Messaging With Financial Incentives

Health Economics, EarlyView.
ABSTRACT Some patients prescribed opioid pills fail to properly dispose of their unused pills, posing a risk for others. We report results from a pre‐registered field experiment testing whether behaviorally informed reminder cards increase participation in a financial incentive program for returning unused opioid pills among U.S. Veterans.
Mattie Toma, Russell Burnett, Pompa Debroy, Eugen Dimant, Jean Liu, Elana Safran, Uzaib Saya, Bill Schultz   +7 more
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. [PDF]

, 2017
INTRODUCTION:The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways.
Chidambaran, Vidya, Ding, Lili, Geisler, Kristie, Ji, Hong, Martin, Lisa J, Sadhasivam, Senthilkumar, Stubbeman, Bobbie L, Weirauch, Matthew T, Zhang, Xue   +8 more
core   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Role of Orexin in the Tolerance and Physical Dependence to Morphine

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2014
BACKGROUND AND OBJECTIVE: Although opioid drugs cause analgesia and more effective in treatment of pain but, its utility is hindered by the development of tolerance to its analgesic effects.
Samad Nazemi, Hassan Azhdari zarmrhri, Hashem Haghdoost-Yazdi   +2 more
doaj  

Changes of Adenylate Cyclase and Guanylate Cyclase in the Frontal Cortex, Lenticula, Corpus Amygdaloideum, and Hippocampus in Morphine-dependent Rats

Journal of Forensic Science and Medicine, 2016
To detect the changes of adenylate cyclase (AC) and guanylate cyclase (GC) in the four cerebral regions that are concerned with psychogenic dependence of morphine in rats, including the frontal cortex, lenticula, corpus amygdaloideum, and hippocampus. To
Shijun Hong, Dongxian Zhang, Lihua Li
doaj   +1 more source

Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome [PDF]

, 2017
No abstract ...
Allocco, Bier, Desai, Dryden, Gibson, Hodgson, Jones, Kocherlakota, Liu, Mactier, Maeda, McGlone, McGlone, Noormohammadi, Steinhorn, Yuan   +15 more
core   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source