Results 91 to 100 of about 24,480 (215)

The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. [PDF]

Neuropsychopharmacology, 2018
Lee K, Vuong HE, Nusbaum DJ, Hsiao EY, Evans CJ, Taylor AMW.   +5 more
europepmc   +1 more source

From Executor to Orchestrator: The Pharmacology Scientist in the Age of Agentic AI

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 648-662, September 2026.
Drug development productivity has not improved despite five decades of computational advancement, with the probability that a compound entering Phase I achieving regulatory approval remaining near 10%. Each automation wave increased throughput while leaving the interpretive bottleneck intact; scientists continued to formulate questions, evaluate ...
Michael McCoy, Matthew McCoy
wiley   +1 more source

KCTD proteins regulate morphine dependence via heterologous sensitization of adenylyl cyclase 1 in mice. [PDF]

PLoS Biol
Ding Z, Zhang C, Yang H, Chen J, Sun Z, Zhen X.   +5 more
europepmc   +1 more source

ELECTROENCEPHALOGRAPHIC STUDIES ON MORPHINE DEPENDENCE IN RABBIT

Japanese Journal of Pharmacology, 1966
YAMATSU, KIYOMI, TAKAGI, HIROSHI
openaire   +3 more sources

Effects of Topical Administration of Bupivacaine HCl to the Ovarian Pedicle on Postoperative Pain, Antioxidant Enzyme Activity and Inflammatory Cytokines in Dogs Undergoing Laparoscopic Ovariectomy

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Topical bupivacaine HCl applied to the ovarian pedicle during laparoscopic ovariectomy in dogs significantly reduced early postoperative UMPS pain scores and modulated antioxidant enzyme activity (SOD, CAT). However, systemic pro‐inflammatory cytokine levels (IL‐1β, IL‐6 and TNF‐α) remained unchanged between groups.
Alper Yasin Çiplak, Bülent Polat
wiley   +1 more source

Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence. [PDF]

CNS Neurosci Ther
Quezada M, Ponce C, Berríos-Cárcamo P, Santapau D, Gallardo J, De Gregorio C, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M, Israel Y, Andrés-Herrera P, Hipólito L, Ezquer F.   +13 more
europepmc   +1 more source

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes. [PDF]

Molecules, 2018
Ou J, Zhou Y, Li C, Chen Z, Li H, Fang M, Zhu C, Huo C, Yung KK, Li J, Luo C, Mo Z.   +11 more
europepmc   +1 more source

Management of Pain in the Intensive Care Unit: A Nordic Survey

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Pain is common in intensive care unit (ICU) patients with up to one‐third experiencing pain at rest and even more during mobilization and clinical procedures. This survey aimed to explore physicians' attitudes and preferences regarding pain management in adult ICU patients in the Nordic countries.
Benedikte Kollerup Madsen, Morten Hylander Møller, Stine Estrup, Lone Musaeus Poulsen, Bodil Steen Rasmussen, Kirstine Sylvester Conradsen, Thomas Lass Klitgaard, Asger Granfeldt, Theis Skovsgaard Itenov, Hans Christian Thorsen Meyer, Signe Tellerup Nielsen, Susanne Andi Iversen, Klaus Tjelle Kristiansen, Morten Heiberg Bestle, Kirsten Møller, Peter Hasse Møller Sørensen, Jeppe Veien Nygaard, Kristian Elgaard, Morten Rune Blichfeldt‐Eckhardt, Ann Christine Waarkjær Olsen, Mette Pedersen, Henrik Westy Hoffmeyer, Peter Martin Hansen, Helle Bundgaard, Marcus Ølgaard Møller, Jarl Sigaard, Kim Zillo Rokamp, Anne Craveiro Brøchner, Christoffer Sølling, Mika Valtonen, Anna‐Maria Kuivalainen, Annukka Vahtera, Stepani Bendel, Martin I. Sigurdsson, Per Martin Bådstøløkken, Fredrik Sjövall, Ole Mathiesen, Lars Peter Kloster Andersen   +37 more
wiley   +1 more source

Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence. [PDF]

Int J Mol Sci, 2019
Shi W, Zhang Y, Zhao G, Wang S, Zhang G, Ma C, Cong B, Li Y.   +7 more
europepmc   +1 more source

Computed Tomographic Volumetric Analysis of the Nasal Cavities in Domestic Cats (Felis catus) and Anatomical Implications for Intranasal Drug Delivery

Anatomia, Histologia, Embryologia, Volume 55, Issue 5, September 2026.
ABSTRACT To perform a computed tomography (CT)‐based volumetric assessment of the nasal cavities in domestic cats and to evaluate the relationship between nasal cavity volume and selected morphometric variables. Fifty‐six European cats that underwent CT examination of the head were retrospectively included.
Montel Charles, Charlier Hippolyte, Paquet Charlène, Jourdan Géraldine, Mogicato Giovanni   +4 more
wiley   +1 more source