Results 31 to 40 of about 25,962 (253)
Dopamine-dependent responses to morphine depend on glucocorticoid receptors [PDF]
Proceedings of the National Academy of Sciences, 1998 Previous work has shown that glucocorticoid hormones facilitate the behavioral and dopaminergic effects of morphine. In this study we examined the possible role in these effects of the two central corticosteroid receptor types: mineralocorticoid receptor (MR), and glucocorticoid receptor (GR).
Marinelli, M +4 more
openaire +3 more sources
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source
Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]
Reviews in Clinical Medicine, 2015 Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar +5 more
doaj +3 more sources
Journal of Pharmacological Sciences, 2007 As functional changes in L-type high voltage-gated calcium channels (HVCCs) are recognized to be one of the major neurochemical modifications occurring in brains of animals with morphine physical dependence, this study attempts to examine whether ...
Masahiro Shibasaki +4 more
doaj +1 more source
Rat brain proteome in morphine dependence
Neurochemistry International, 2006 The aim of this study was to reveal potential markers associated with drug dependence, using the proteomic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem ...
Bierczyńska-Krzysik, Anna +8 more
openaire +3 more sources
Drug Dependence, Synaptic Plasticity, and Tissue Plasminogen Activator
Journal of Pharmacological Sciences, 2005 The mesocorticolimbic dopaminergic system plays an important role in the reinforcing effects of drugs of abuse, and the activity-dependent synaptic plasticity of the system is involved in drug dependence.
Kiyofumi Yamada +2 more
doaj +1 more source
The significance of the adenosinergic system in morphine dependence
Current Issues in Pharmacy and Medical Sciences, 2015 Addiction is a chronic and recurrent disease. In its pathology, neuroadaptive changes within the dopaminergic pathways inside the mesolimbic system play a predominant role.
Lupina Malgorzata, Listos Joanna
doaj +1 more source
Iranian Journal of Medical Sciences, 2014 Background: Chronic use of opioids usually results in physical dependence. The underlying mechanisms for this dependence are still being evaluated. Transient receptor potential vanilloid type 1 (TRPV1) are important receptors of pain perception.
Elham Hakimizadeh +5 more
doaj
Attenuation of morphine tolerance and dependence by thymoquinone in mice [PDF]
Avicenna Journal of Phytomedicine, 2016 Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were ...
Hossein Hosseinzadeh +4 more
doaj
Antinociceptive Activity and Effect of Methanol Extracts of Three Salvia Spp. on Withdrawal Syndrome in Mice [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: There are several reports about effects of Salvia spp. on CNS. The present experiment is undertaken to study effect of S. limbata, S. hypoleuca and S. macrosiphon on withdrawal syndrome in mice.
Mohammad Karami +5 more
doaj +1 more source