Results 21 to 30 of about 25,962 (253)

-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis ...
Siavash Parvardeh, Mahsa Moghimi, Pegah Eslami, Alireza Masoudi   +3 more
doaj  

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence

BMC Neuroscience, 2012
Background Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence.
Wen Di, Ma Chun-ling, Zhang Ya-jing, Meng Yan-xin, Ni Zhi-yu, Li Shu-jin, Cong Bin   +6 more
doaj   +1 more source

Regulation of body weight and food intake by AGRP neurons during opioid dependence and abstinence in mice

Frontiers in Neural Circuits, 2022
Dysregulation of body weight maintenance and opioid dependence are often treated as independent disorders. Here, we assessed the effects of both acute and long-term administration of morphine with and without chemogenetic activation of agouti-related ...
Brenton T. Laing, Aishwarya Jayan, Lydia J. Erbaugh, Anika S. Park, Danielle J. Wilson, Yeka Aponte, Yeka Aponte   +6 more
doaj   +1 more source

Potential of Pramipexole in Attenuating Morphine Dependence: Insights from a Conditioned Place Preference Study in Mice

Cerrahpaşa Medical Journal
Objective: Pramipexole, a selective dopamine D2/D3 receptor agonist, has been implicated in modulating dopaminergic transmission in brain reward circuits.
Andleeb Shahzadi, Oruç Yunusoğlu, Mohamad Alhakim, Selim Gökdemir, Rüveyda Rümeysa Ateşoğlu   +4 more
doaj   +1 more source

Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring

Journal of Biomedical Science, 2009
Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring.
Tao Pao-Luh, Chen Jain-Fang, Wu Ling-Yi, Huang Eagle   +3 more
doaj   +1 more source

Influence of Selective Dopamine Agonist Ropinirole on Conditioned Place Preference and Somatic Signs of Morphine Withdrawal in Rats

Frontiers in Behavioral Neuroscience, 2022
The underlying mechanism of dependence and rewarding effects of morphine is imperative to understand. The primary aim of this study was to investigate whether ropinirole D2/3 agonist affects the rewarding and reinforcing properties of morphine-induced ...
Andleeb Shahzadi, Oruc Yunusoglu, Oruc Yunusoglu, Enes Karabulut, Enes Karabulut, Haktan Sonmez, Zeliha Yazici, Zeliha Yazici   +7 more
doaj   +1 more source

The role of mPer1 in morphine dependence in mice [PDF]

Neuroscience, 2005
Investigations using Drosophila melanogaster have shown that the circadian clock gene period can influence behavioral responses to cocaine, and the mouse homologues, mPer1 and mPer2, modulate cocaine sensitization and reward. In the present study, we applied DNAzyme targeting mPer1 to interfere the expression of mPer1 in CNS in mice and studied the ...
Y, Liu, Y, Wang, C, Wan, W, Zhou, T, Peng, Y, Liu, Z, Wang, G, Li, G, Cornelisson, F, Halberg   +9 more
openaire   +2 more sources

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source