Results 21 to 30 of about 54,444 (297)
The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence
Pharmaceuticals, 2021 The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction.
Lamees Alhassen +6 more
doaj +1 more source
Dopamine-dependent responses to morphine depend on glucocorticoid receptors [PDF]
Proceedings of the National Academy of Sciences, 1998 Previous work has shown that glucocorticoid hormones facilitate the behavioral and dopaminergic effects of morphine. In this study we examined the possible role in these effects of the two central corticosteroid receptor types: mineralocorticoid receptor (MR), and glucocorticoid receptor (GR).
M, Marinelli +4 more
openaire +2 more sources
Drug addiction as a physical disease:The role of physical dependence and other chronic drug-induced neurophysiological changes in compulsive drug self-administration [PDF]
, 1998 Physical-dependence-based theories of addiction regard compulsive drug taking as the behavioral manifestation of a desperate need to relieve aversive autonomic withdrawal symptoms.
Lyvers, Michael
core +1 more source
Toxicological Analysis of Some Drugs of Abuse in Biological Samples [PDF]
, 2015 Consumption of drugs of abuse is a scourge of modern world. Abuse, drug addiction and their consequences are one of the major current problems of European society because of the significant repercussions in individual, family, social and economic level ...
Baconi, Daniela Luiza +5 more
core +3 more sources
Rat brain proteome in morphine dependence
Neurochemistry International, 2006 The aim of this study was to reveal potential markers associated with drug dependence, using the proteomic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem ...
Bierczyńska-Krzysik, Anna +8 more
openaire +3 more sources
Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]
, 2012 Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi +42 more
core +2 more sources
Narcotics Addiction and Its Treatment [PDF]
, 1957 The ongoing mythologizing of the poet in both criticism and, as recently in a play produced by Wasa teater (Vasa), is reductive, and needs to be confronted.
Winick, Charles
core +4 more sources
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis ...
Siavash Parvardeh +3 more
doaj
BMC Neuroscience, 2012 Background Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence.
Wen Di +6 more
doaj +1 more source
Frontiers in Neural Circuits, 2022 Dysregulation of body weight maintenance and opioid dependence are often treated as independent disorders. Here, we assessed the effects of both acute and long-term administration of morphine with and without chemogenetic activation of agouti-related ...
Brenton T. Laing +6 more
doaj +1 more source