Results 11 to 20 of about 25,962 (253)
Decoding the Neural Circuit Underlying Context-Cue Association in Retrieval of Morphine Reward Memory. [PDF]
Adv Sci (Weinh)Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Shi Z +8 more
europepmc +2 more sources
Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. [PDF]
PLoS ONE, 2011 Opiates produce significant and persistent changes in synaptic transmission; knowledge of the proteins involved in these changes may help to understand the molecular mechanisms underlying opiate dependence. Using an integrated quantitative proteomics and
Noura S Abul-Husn +7 more
doaj +1 more source
Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1
Frontiers in Pharmacology, 2020 Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence.
Xian-Si Zeng +3 more
doaj +1 more source
The effect of metformin on morphine analgesic tolerance and dependence in rats
Research in Pharmaceutical Sciences, 2018 Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi +3 more
doaj +1 more source
Agmatine synthesis in morphine dependence [PDF]
Annals of General Psychiatry, 2006 Regunathan Soundar, Aricioglu Feyza
doaj +2 more sources
Preference for Morphine and Drug-Seeking Behavior in Morphine Dependent Rats.
Japanese Journal of Pharmacology, 1978 We have already reported that morphine pretreated rats prefered morphine-admixed food during choice trials with the two cup method. In the present work, we utilized both the five and two cup methods and observed the preference for morphine in rats forcedly pretreated with the drug and the increasing rate of preference for the drug in rats where the ...
YANAURA, Saizo, SUZUKI, Tsutomu
openaire +5 more sources
Zagazig Journal of Pharmaceutical Sciences, 2020 Chronic use of opioids as morphine and tramadol to control pain is associated with several side effects and tolerance to their analgesic effect and dependence. Some of the side effects of opioids can be ameliorated by naloxone, however this is associated
Waleed Barakat +3 more
doaj +1 more source
Fatal dependence on kaolin and morphine mixture [PDF]
Postgraduate Medical Journal, 1980 Summary A patient is described who had a long history of abuse of kaolin and morphine mixture which ultimately proved fatal.
J M, Barragry, D V, Morris
openaire +2 more sources
The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence
Pharmaceuticals, 2021 The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction.
Lamees Alhassen +6 more
doaj +1 more source
Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont
Angewandte Chemie, EarlyView.Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley +11 more
wiley +2 more sources