Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. [PDF]
PLoS ONE, 2011 Opiates produce significant and persistent changes in synaptic transmission; knowledge of the proteins involved in these changes may help to understand the molecular mechanisms underlying opiate dependence. Using an integrated quantitative proteomics and
Noura S Abul-Husn +7 more
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Agmatine synthesis in morphine dependence [PDF]
Annals of General Psychiatry, 2006 Regunathan Soundar, Aricioglu Feyza
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Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
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Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1
Frontiers in Pharmacology, 2020 Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence.
Xian-Si Zeng +3 more
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The effect of metformin on morphine analgesic tolerance and dependence in rats
Research in Pharmaceutical Sciences, 2018 Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi +3 more
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Zagazig Journal of Pharmaceutical Sciences, 2020 Chronic use of opioids as morphine and tramadol to control pain is associated with several side effects and tolerance to their analgesic effect and dependence. Some of the side effects of opioids can be ameliorated by naloxone, however this is associated
Waleed Barakat +3 more
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Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]
, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
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Eating Pattern of Morphine Dependent Rats
Japanese Journal of Pharmacology, 1979 To analyze the drug ingestion patterns of rats in the course of dependence development while on the drug-admixed food (DAF) method, an automatic food intake measuring apparatus was developed. Rats were put on morphine-admixed food, and the food ingestion patterns were recorded with the apparatus in the course of dependence development, during drug ...
S, Yanaura, T, Suzuki
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Effects of ATPM-ET, a novel κ agonist with partial μ activity, on physical dependence and behavior sensitization in mice [PDF]
, 2014 Aim: To investigate the effects of ATPM-ET [(−)-3-N-Ethylaminothiazolo [5,4-b]-N-cyclopropylmethylmorphinan hydrochloride] on physical dependence and behavioral sensitization to morphine in mice.
Chen, Jie +11 more
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The challenge of perioperative pain management in opioid-tolerant patients [PDF]
, 2017 The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F +9 more
core +2 more sources