Results 1 to 10 of about 790 (211)

Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

Cell Reports, 2019
Summary: The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference
Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Woojin Won, Wuhyun Koh, Jin Young Bae, Junsung Woo, Jayoung Kim, Elliot Kwong, Tae-Yong Choi, Heejung Chun, Seung Eun Lee, Sang-Bum Kim, Ki Duk Park, Se-Young Choi, Yong Chul Bae, C. Justin Lee   +16 more
doaj   +3 more sources

Impact of Exercise on Tramadol-Conditioned Place Preference

Brain Sciences
Background: Tramadol (TRA) is an opioid that is used to manage moderate to severe pain. Long-term use of TRA can lead to the development of opioid use disorder.
Haneen Amawi, Alaa M. Hammad, Aseel Abdullah Ibrahim, Nosyba Alsbih, Frank Scott Hall, Fawaz Alasmari, Bahaa Al-Trad   +6 more
doaj   +3 more sources

Examining Sex Differences in Conditioned Place Preference or Aversion to Methamphetamine in Adolescent and Adult Mice

Frontiers in Pharmacology, 2021
Adolescence marks a particularly vulnerable period to developing substance use disorders. Human and rodent studies suggest that hypersensitivity to reward may contribute towards such vulnerability when adolescents are exposed to casual drug use ...
Ellen R. Cullity, Ellen R. Cullity, Alexandre A. Guerin, Alexandre A. Guerin, Christina J. Perry, Christina J. Perry, Jee Hyun Kim, Jee Hyun Kim, Jee Hyun Kim   +8 more
doaj   +1 more source

An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats

Scientific Reports, 2023
Inter-relationships between pain sensitivity, drug reward, and drug misuse are of considerable interest given that many analgesics exhibit misuse potential.
Ariana C. Brice-Tutt, Darrice S. Montgomery, Cassidy M. Kramer, Peter M. Novotny, Wendi L. Malphurs, Abhisheak Sharma, Robert. M. Caudle, Adriaan W. Bruijnzeel, Barry Setlow, John K. Neubert, Niall P. Murphy   +10 more
doaj   +1 more source

Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway

Pharmaceuticals, 2021
Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals.
Yusuf S. Althobaiti
doaj   +1 more source

Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction

Biomolecules, 2023
Cocaine addiction is a serious condition with potentially lethal complications and no current pharmacological approaches towards treatment. Perturbations of the mesolimbic dopamine system are crucial to the establishment of cocaine-induced conditioned ...
Daniel R. Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andressoo   +3 more
doaj   +1 more source

Spermidine prevents the reinstatement of alcohol conditioned place preference

Addiction Neuroscience, 2023
This study investigates whether spermidine (SPD), an endogenous polyamine, alters extinction and reinstatement of alcohol-induced conditioned place preference (CPP) in adult female Swiss mice.
Avner Almeida Silva, Gabrielle de Morais Henriques, Victor Nascimento-Rocha, Behaim Correia Dias-Júnior, Alexia dos Anjos Santos, Alexandre Justo Oliveira Lima, Eduardo Ary Villela Marinho, Maribel Antonello Rubin, Carlos Fernando Mello   +8 more
doaj   +1 more source

Conditioned place preference behavior in zebrafish [PDF]

Nature Protocols, 2011
This protocol describes conditioned place preference (CPP) in zebrafish following a single exposure to a substance. In the CPP paradigm, animals show a preference for an environment that has previously been associated with a substance (drug), thus indicating the positive-reinforcing qualities of that substance.
Priya, Mathur, Billy, Lau, Su, Guo
openaire   +2 more sources

Differences in the Alcohol Preference Assessment of Shy and Bold Zebrafish

Frontiers in Behavioral Neuroscience, 2022
Individuals differ in their preference for alcohol and propensity to develop alcoholism, where the behavioral profile, such as the bold-shy axis, plays an important role for such a difference.
Marina Sanson Bellot, Marina Sanson Bellot, Isabela Inforzato Guermandi, Bruno Camargo-dos-Santos, Bruno Camargo-dos-Santos, Percília Cardoso Giaquinto, Percília Cardoso Giaquinto   +6 more
doaj   +1 more source

Running Reward Conditioned Place Preference Task

Bio-Protocol, 2016
The conditioned place preference (CPP) test is a standard pre-clinical behavioral tool used to study the motivational effects of drugs and non-drug treatments in experimental animals.
Maria Fernandes, Stephanie Fulton
doaj   +1 more source