Results 21 to 30 of about 22,902 (258)
Frontiers in Pharmacology, 2021 Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders.
Gabrielle M. Henriques +17 more
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Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior
Molecules, 2021 The popular tobacco and e-cigarette chemical flavorant (−)-menthol acts as a nonselective, noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs), and contributes to multiple physiological effects that exacerbates nicotine addiction ...
Skylar Y. Cooper +3 more
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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
Cell Reports, 2019 Summary: The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference
Min-Ho Nam +16 more
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Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways
Frontiers in Behavioral Neuroscience, 2019 Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV+ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely ...
Xi Chen +4 more
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Naloxone blockade of amphetamine place preference conditioning [PDF]
Psychopharmacology, 1991 Amphetamine and naloxone were examined in place conditioning, in order to study possible interactions between endogenous opioids and catecholamines in reinforcement. After initial preferences were determined, animals were conditioned with amphetamine alone (1.0 mg/kg SC), naloxone alone (0.02, 0.2 or 2.0 mg/kg SC) or combinations of amphetamine plus ...
Belluzzi, James D. +2 more
openaire +3 more sources
Brain Sciences, 2012 Reinstatement of conditioned place preferences have been used to investigate physiological mechanisms mediating drug-seeking behavior in adolescent and adult rodents; however, it is still unclear how psychostimulant exposure during adolescence affects ...
Kimberly A. Badanich, Cheryl L. Kirstein
doaj +1 more source
PLoS ONE, 2014 The function of TRPV1 (transient receptor potential vanilloid subfamily, member 1) in the central nervous system is gradually elucidated. It has been recently proved to be expressed in nucleus accumbens (NAc), a region playing an essential role in ...
Li-Jun Heng +8 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu +8 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker +11 more
wiley +1 more source
Place conditioning as evaluation of affective valence in piglets
Scientific ReportsThe emotional valence of animals is challenging to assess, despite being a key component of welfare. In this study, we attempted to assess emotional valence through memory in 1- and 3-week-old piglets.
Thomas Ede +2 more
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