Results 21 to 30 of about 197,171 (310)
Advanced Biomedical Research, 2023 Background: The involvement of lateral habenula and the ineffective dose of morphine on reward-related learning and memory is less well-known. This study looked into the effects of electrical stimulation, GABAB receptor blockade, and a combination of ...
Elahe Amohashemi +2 more
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Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference [PDF]
, 2014 Background Phosphodiesterase (PDE) 10A is selectively expressed in medium spiny neurons of the striatum. Nucleus accumbens (NAc) is a key region that mediates drug reward and addiction-related behaviors. To investigate the potential role of PDE10A in the
Bo Gao +7 more
core +3 more sources
Intolerance of uncertainty and conditioned place preference in opioid addiction [PDF]
PeerJ, 2018 Several personality factors have been implicated in vulnerability to addiction by impacting learning and decision making. One such factor is intolerance of uncertainty (IU), the tendency to perceive uncertain situations negatively and avoid them ...
Milen L. Radell +6 more
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Journal of Biomedical Science, 2017 Background Long-term potentiation (LTP) is well recognized as a cellular-correlated synaptic plasticity of learning and memory. However, its reversal forms of synaptic plasticity, depotentiation, is less studied and its association with behaviors is also
Guan-Ling Lu, Hau-Jie Yau, Lih-Chu Chiou
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Frontiers in Pharmacology, 2021 Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders.
Gabrielle M. Henriques +17 more
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Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior
Molecules, 2021 The popular tobacco and e-cigarette chemical flavorant (−)-menthol acts as a nonselective, noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs), and contributes to multiple physiological effects that exacerbates nicotine addiction ...
Skylar Y. Cooper +3 more
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Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations [PDF]
, 2017 Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the original unconditioned stimulus.
Bruchas, Michael R +4 more
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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
Cell Reports, 2019 Summary: The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference
Min-Ho Nam +16 more
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Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors [PDF]
, 2010 Methylphenidate (MP) and amphetamine (AMPH) are the most frequently prescribed medications for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Bermeo, C. +6 more
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Parvalbumin Interneurons Determine Emotional Valence Through Modulating Accumbal Output Pathways
Frontiers in Behavioral Neuroscience, 2019 Parvalbumin (PV) expressing GABAergic interneurons provide large source of GABA to spiny projection neurons (SPNs) in the striatum. However, the roles of PV+ interneurons in the regulation of SPNs in the ventral striatum and emotional states are largely ...
Xi Chen +4 more
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