Results 1 to 10 of about 905,086 (195)

Respiration in Sprague-Dawley Rats During Pregnancy

Inhalation Toxicology, 2006
Minute ventilation and tidal volume increase in humans during pregnancy. Little data exists, however, on the respiration in pregnant rats, despite their widespread use as an animal model. Since respiration will affect the pharmacokinetics of volatile compounds and ultimately the dose to the fetus, we conducted a study to evaluate respiration in rats ...
Teresa L, Leavens, Carl U, Parkinson, R Arden, James, Dennis, House, Barbara, Elswick, David C, Dorman   +5 more
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Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in sprague-dawley rats

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1977
Nitrosoazetidine was fed to rats in drinking water at three different concentrations. At 2 mmol (10 mmol total dose) all of the rats died with hepatocellular carcinomas by the 62nd week. This was a greater response than to an equivalent dose of nitrosopyrrolidine. At 0.67 mmol, 6 of 21 rats developed liver tumors, and at 0.17 millimolar 2 of 30 animals
W, Lijinsky, H W, Taylor
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Carcinogenicity of 8-nitroquinoline in Sprague—Dawley rats

Cancer Letters, 1978
8-Nitroquinoline was added to the semisynthetic diet of outbred Sprague-Dawley rats for 48 weeks. Squamous cell carcinomas of the upper digestive tract (tongue and esophagus), but especially of the forestomach, occurred among the higher concentration groups.
M, Takahashi, T, Shirai, S, Fukushima, K, Hosoda, S, Yoshida, N, Ito   +5 more
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Spontaneous brain tumours in Sprague-Dawley rats

Food and Chemical Toxicology, 1986
Data were collected over a 5-yr period on brain tumours occurring spontaneously among Sprague-Dawley-derived rats in the HRC laboratories. Gliomas, like meningiomas, tended to occur more among males than in females, and in general appeared to be lesions of older rats. Astrocytic tumours of rats were less differentiated than those in man.
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Spontaneous neoplasms in aged sprague-dawley rats

Archives of Toxicology, 1992
Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid ...
M, Chandra, M G, Riley, D E, Johnson
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Developmental Toxicity of Thiodiglycol in Sprague-Dawley Rats

International Journal of Toxicology, 2007
Thiodiglycol (TG), a hydrolysis product of sulfur mustard (HD), is a potential contaminant of soil and water at certain military sites. To establish developmental toxicity criteria for TG, an oral developmental toxicity study was conducted in Sprague-Dawley rats.
John T, Houpt, Lee C B, Crouse, Richard A, Angerhofer, Glenn J, Leach, Gunda, Reddy   +4 more
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Inherited tertiary hypothyroidism in Sprague–Dawley rats

Brain Research, 2007
Thyroid hormones (THs) are important in the development and maturation of the central nervous system (CNS). The significant actions of THs during CNS development occur at the time when TH levels are lower than those in the mother and the hypothalamic-thyroid (HPT) axis is not fully functional.
George, Stoica, Gina, Lungu, Xueyi, Xie, Louise C, Abbott, Heidi M, Stoica, John T, Jaques   +5 more
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Ozone uptake in awake Sprague-Dawley rats

Toxicology and Applied Pharmacology, 1987
Knowledge of ozone (O3) uptake in rats in integral to efforts to quantitatively extrapolate animal data to man. We have measured percentage O3 uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6, or 1.0 ppm O3. Tidal volume and breathing rate measurements, obtained by plethysmography, were time-matched with changes in ...
M J, Wiester, T B, Williams, M E, King, M G, Ménache, F J, Miller   +4 more
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The Impact of Hyperuricemia on Pharmacokinetics in Sprague–Dawley Rats

European Journal of Drug Metabolism and Pharmacokinetics
Hyperuricemia (HUA) is a metabolic disease closely associated with hypertension. It can induce liver damage, subsequently affecting drug metabolism. However, its specific impacts and underlying mechanisms remain unclear. Therefore, the pharmacokinetics and cytochrome P450 (CYP450) enzyme activities were investigated.Twelve healthy Sprague-Dawley rats ...
Xiaomeng Pan, Dandan Li, Yujuan Chen, JiaMian Lu, Yakun Yang, Yusong Guo, Dezhi Kong, Wei Guo   +7 more
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Teratogenicity of 5‐azacytidine in the Sprague‐Dawley rat

Journal of Toxicology and Environmental Health, 1990
5-Azacytidine (5-aza), a chemical that is incorporated into DNA and RNA with consequent alterations in the expression of mammalian genes, was administered to pregnant Sprague-Dawley rats on single days during gestation. Doses of 0.5, 1, and 2 mg/kg were given by intraperitoneal injection on d 9, 10, 11, or 12.
M B, Rosen, H S, House, B M, Francis, N, Chernoff   +3 more
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