Results 1 to 10 of about 419,320 (165)

Equivalent intraperitoneal doses of ibuprofen supplemented in drinking water or in diet: a behavioral and biochemical assay using antinociceptive and thromboxane inhibitory dose–response curves in mice [PDF]

PeerJ, 2016
Background. Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life.
Raghda A.M. Salama, Nesreen H. El Gayar, Sonia S. Georgy, May Hamza   +3 more
doaj   +2 more sources

Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist

Heliyon, 2019
Objective: To identify an agonist of RXRα and RARα with reduced undesired profiles of all-trans retinoic acid for differentiation-inducing therapy of acute promyelocytic leukemia (APL), such as its susceptibility to P450 enzyme, induction of P450 enzyme,
Chie Koshiishi, Takanori Kanazawa, Eric Vangrevelinghe, Toshiyuki Honda, Shinji Hatakeyama   +4 more
doaj   +1 more source

The pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noise. [PDF]

PLoS Computational Biology, 2014
In this work we investigate, by means of a computational stochastic model, how tumor cells with wild-type p53 gene respond to the drug Nutlin, an agent that interferes with the Mdm2-mediated p53 regulation.
Krzysztof Puszynski, Alberto Gandolfi, Alberto d'Onofrio   +2 more
doaj   +1 more source

Data from Dose–Response Relationship in Phase I Clinical Trials: A European Drug Development Network (EDDN) Collaboration Study

, 2023
<div>Abstract<p><b>Introduction:</b> Because a dose–response relationship is characteristic of conventional chemotherapy, this concept is widely used for the development of novel cytotoxic (CTX) drugs. However, the need to reach the MTD to obtain optimal benefit with molecularly targeted agents (MTA) is controversial.
Stan B. Kaye, Jaap Verweij, Josep Tabernero, Jean Charles Soria, Richard H. Wilson, Ruth Plummer, Jeffrey Evans, Emile Voest, Nicolas Penel, Jan H.M. Schellens, Silvia Marsoni, Patrick Schöffski, Andre T. Brunetto, Elisa Gallerani, Gianluca Del Conte, Rafael Morales-Barrera, Philippe A. Cassier, Carlos Gomez-Roca, David Olmos, Victor Moreno García   +19 more
openaire   +1 more source

Open label, dose escalation trial of creatine monohydrate in pregnancy

Journal of the International Society of Sports Nutrition
Background Preclinical data demonstrates that creatine supplementation during pregnancy supports maternal and fetal energy homeostasis through periods of hypoxia, but its use in human pregnancy remains unexplored.
Madison Naidu, Deborah L de Guingand, Georgina Hunter, Nhi T Tran, Rod J Snow, Carl M Kirkpatrick, Stacey J Ellery, Kirsten R Palmer   +7 more
doaj   +1 more source

Efficacy of high-dose vs. low-dose intravitreal ganciclovir for cytomegalovirus retinitis: a systematic review and meta-analysis [PDF]

Journal of Yeungnam Medical Science
Background Intravitreal ganciclovir is widely used to achieve effective local antiviral concentrations for cytomegalovirus (CMV) retinitis; however, to our knowledge, standardized dosing strategies have not been established, and the reported regimens ...
Seongyong Jeong, Areum Jeong, Jae Rock Do, Yong Koo Kang, Min Sagong   +4 more
doaj   +1 more source

Are plasma drug concentrations still necessary? Rethinking the pharmacokinetic link in dose–response relationships

Frontiers in Pharmacology
Plasma drug concentrations have historically played a central role in pharmacology, serving as a measurable intermediary between administered dose and clinical response. This model, linking Dose, Concentration and Effect, underpins therapeutic drug monitoring, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and regulatory evaluation.
Nicolas Simon, Katharina von Fabeck
openaire   +4 more sources

Dose-response relationship of MSCs as living Bio-drugs in HFrEF patients: a systematic review and meta-analysis of RCTs

Stem Cell Research & Therapy
Abstract Background Mesenchymal stem cells (MSCs) have emerged as living biodrugs for myocardial repair and regeneration. Recent randomized controlled trials (RCTs) have reported that MSC-based therapy is safe and effective in heart failure patients; however, its dose-response relationship has yet to be established.
Ziyad T. Ahmed, Maha Saad Zain Al-Abeden, Mohamed Ghaith Al Abdin, Mohamad Ayham Muqresh, Ghazi I. Al Jowf, Lars M. T. Eijssen, Khawaja Husnain Haider   +6 more
openaire   +3 more sources

The 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial [PDF]

Korean Journal of Anesthesiology
Background As ultrasound imaging technology matured, stellate ganglion blocks (SGBs) have become increasingly precise and safe, and their use in clinical practice has become widespread. However, the 90% minimum effective volume (MEV90) and concentration (
Shujun Sun, Qinghua Yin, Jiwei Shen, Yang Lv, Long Li, Zhangyan Mao, Yun Lin, Xiangdong Chen, Dong Yang   +8 more
doaj   +1 more source

An Innovative Disease‐Drug‐Trial Framework to Guide Binge Eating Disorder Drug Development: A Case Study for Topiramate

Clinical and Translational Science, 2020
As with other psychiatric disorders, development of drugs to treat binge‐eating disorder (BED) has been hampered by high placebo response and dropout rates in randomized controlled trials (RCTs).
Shamir N. Kalaria, Susan L. McElroy, Jogarao Gobburu, Mathangi Gopalakrishnan   +3 more
doaj   +1 more source