Results 31 to 40 of about 419,320 (165)

Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review

Antibiotics, 2022
Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development.
Laiz Campos Pereira, Marcelo Aguiar de Fátima, Valdeene Vieira Santos, Carolina Magalhães Brandão, Izabel Almeida Alves, Francine Johansson Azeredo   +5 more
doaj   +1 more source

Tacrolimus concentration/dose ratio as a therapeutic drug monitoring strategy: The influence of gender and comedication [PDF]

Vojnosanitetski Pregled, 2015
Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been commonly used immunosuppresive regimens. On the other hand, there is a growing body of evidence that male and female may differ in their response to the
Rančić Nemanja, Dragojević-Simić Viktorija, Vavić Neven, Kovačević Aleksandra, Šegrt Zoran, Drašković-Pavlović Biljana, Mikov Momir   +6 more
doaj   +1 more source

A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe

Frontiers in Pharmacology, 2021
Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Jeroen V. Koomen, Jeroen V. Koomen, Jasper Stevens, Margje H. Monster-Simons, Margje H. Monster-Simons, Hiddo J. L. Heerspink, Peter G. M. Mol, Peter G. M. Mol   +7 more
doaj   +1 more source

Evaluation of the anticoagulant effect of vitamin K antagonists in patients with non-valvular atrial fibrilation [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Despite the introduction of new oral anticoagulants (dabigatran, rivoroxaban, apixaban), vitamin K antagonists (VKA), such as warfarin and acenocoumarol are still the most widely used oral anticoagulants for the treatment of nonvalvular ...
Stanojković Zoran, Antić Ana, Balint Bela, Todorović Milena, Vučić Miodrag, Vacić Nebojša, Lazarević Milan   +6 more
doaj   +1 more source

Dose-response relationship in phase I clinical trials: A European Drug Development Network (EDDN) collaboration study. [PDF]

Journal of Clinical Oncology, 2011
Abstract Introduction: Because a dose–response relationship is characteristic of conventional chemotherapy, this concept is widely used for the development of novel cytotoxic (CTX) drugs. However, the need to reach the MTD to obtain optimal benefit with molecularly targeted agents (MTA) is controversial.
Garcia VM, Olmos D, Gomez-Roca C, Cassier PA, Morales-Barrera R, Del Conte G, Gallerani E, Brunetto AT, Schoffski P, Marsoni S, Schellens JHM, Penel N, Voest E, Evans J, Plummer R, Wilson RH, Soria JC, Tabernero J, Verweij J, Kaye SB   +19 more
openaire   +6 more sources

A strategy to model nonmonotonic dose-response curve and estimate IC50. [PDF]

PLoS ONE, 2013
The half-maximal inhibitory concentration IC[Formula: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic ...
Hui Zhang, Jeanne Holden-Wiltse, Jiong Wang, Hua Liang   +3 more
doaj   +1 more source

Efikasnost terapijskog monitoringa ciklosporina određivanjem C2 i PIK0−4 tokom prva 24 meseca posle transplantacije bubrega [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Cyclosporine (CyA) therapeutic drug monitoring (TDM) through the measurement of drug concentration in blood two hours after the administration (C2), and/or according to the calculated value of the area under the concentration - time curve
Vavić Neven, Ignjatović Ljiljana, Drašković Biljana, Hrvačević Rajko, Kovačević Zoran, Paunić Zoran   +5 more
doaj   +1 more source

Amoxicillin/Metronidazole Dose Impact as an Adjunctive Therapy for Stage II - III Grade C Periodontitis (Aggressive Periodontitis) at 3- And 6-Month Follow-Ups: a Systematic Review and Meta-Analysis

eJournal of Oral Maxillofacial Research, 2022
Objectives: This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II - III grade C periodontitis (aggressive periodontitis) after current follow-up ...
Malihe Karrabi, Zahra Baghani
doaj   +1 more source

Dose-response relationship between antimicrobial drugs and livestock-associated MRSA in pig farming.

Emerging infectious diseases, 2015
The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011-2013, an 18-month longitudinal study aimed at reducing the prevalence of LA-MRSA was conducted on 36 pig farms in the Netherlands.
Dorado-García, Alejandro, Dohmen, Wietske, Bos, Marian E H, Verstappen, Koen M, Houben, Manon, Wagenaar, Jaap A, Heederik, Dick J J   +6 more
openaire   +7 more sources

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
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