Results 31 to 40 of about 435,631 (309)

Targeted randomization dose optimization trials enable fractional dosing of scarce drugs.

PLoS ONE, 2023
Administering drug at a dose lower than that used in pivotal clinical trials, known as fractional dosing, can stretch scarce resources. Implementing fractional dosing with confidence requires understanding a drug's dose-response relationship.
Philip S Boonstra, Alex Tabarrok, Garth W Strohbehn   +2 more
doaj   +1 more source

A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe

Frontiers in Pharmacology, 2021
Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Jeroen V. Koomen, Jeroen V. Koomen, Jasper Stevens, Margje H. Monster-Simons, Margje H. Monster-Simons, Hiddo J. L. Heerspink, Peter G. M. Mol, Peter G. M. Mol   +7 more
doaj   +1 more source

Patient factors associated with SSRI dose for depression treatment in general practice:A primary care cross sectional study [PDF]

, 2014
Background: Antidepressant prescribing continues to rise. Increased long-term prescribing and higher doses are contributing to current growth; however, patient factors associated with the use of higher doses remain unknown.
Brian Williams, Dougall, Nadine J., Chris F Johnson, Buchanan, Alasdair I, Stephen A MacGillivray, MacGillivray, Stephen A, Dougall, Nadine J, Buchanan, Alasdair I., Dougall, Nadine, Nadine J Dougall, Hassett, Richard D, Johnson, Chris F, Williams, Brian, Johnson, Chris F., Hassett, Richard D., MacGillivray, Stephen A.; id_orcid, Alasdair I Buchanan, MacGillivray, Steve, Richard D Hassett   +18 more
core   +1 more source

Open-label comparative clinical study of chlorproguanil−dapsone fixed dose combination (Lapdap™) alone or with three different doses of artesunate for uncomplicated plasmodium falciparum malaria [PDF]

, 2008
The objective of this study was to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil−dapsone (CPG−DDS) for the treatment of uncomplicated falciparum ...
Peter A Winstanley, Nyirenda, Maggie, Kanjala, Maxwell K., Molyneux, Malcolm, Sam Dunyo, Stephan Duparc, Paula L Kirby, Winstanley Peter A., Kirby, Paula L., Blencowe, Hannah, Daniel G Wootton, Woessner, Mary, Thomas Kanyok, Stephen Ward, Opara, Hyginus, Molyneux Malcolm, Winstanley, Peter A, Wootton Daniel G., Maggie Nyirenda, Ward, Stephen, Dunyo, Sam, Giancarlo A Biagini, Kanjala, Maxwell K, Nyirenda Maggie, Kanyok Thomas, Maxwell K Kanjala, Opara Hyginus, Duparc, Stephan, Kanyok, Thomas, Queen Dube-Mbeye, Duparc Stephan, Malcolm Molyneux, Neate, Colin, Biagini, Giancarlo A, Biagini Giancarlo A., Ward Stephen, Kirby Paula L., Wootton, Daniel G., Wootton, Daniel G, Kirby, Paula L, Hannah Blencowe, Mary Woessner, Kanjala Maxwell K., Molyneux, Malcolm E., Biagini, Giancarlo A., Woessner Mary, Dube-Mbeye Queen, Colin Neate, Hyginus Opara, Neate Colin, Blencowe Hannah, Dunyo Sam, Winstanley, Peter, Dube-Mbeye, Queen   +53 more
core   +1 more source

A strategy to model nonmonotonic dose-response curve and estimate IC50. [PDF]

PLoS ONE, 2013
The half-maximal inhibitory concentration IC[Formula: see text] is an important pharmacodynamic index of drug effectiveness. To estimate this value, the dose response relationship needs to be established, which is generally achieved by fitting monotonic ...
Hui Zhang, Jeanne Holden-Wiltse, Jiong Wang, Hua Liang   +3 more
doaj   +1 more source

Efikasnost terapijskog monitoringa ciklosporina određivanjem C2 i PIK0−4 tokom prva 24 meseca posle transplantacije bubrega [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Cyclosporine (CyA) therapeutic drug monitoring (TDM) through the measurement of drug concentration in blood two hours after the administration (C2), and/or according to the calculated value of the area under the concentration - time curve
Vavić Neven, Ignjatović Ljiljana, Drašković Biljana, Hrvačević Rajko, Kovačević Zoran, Paunić Zoran   +5 more
doaj   +1 more source

Amoxicillin/Metronidazole Dose Impact as an Adjunctive Therapy for Stage II - III Grade C Periodontitis (Aggressive Periodontitis) at 3- And 6-Month Follow-Ups: a Systematic Review and Meta-Analysis

eJournal of Oral Maxillofacial Research, 2022
Objectives: This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II - III grade C periodontitis (aggressive periodontitis) after current follow-up ...
Malihe Karrabi, Zahra Baghani
doaj   +1 more source

Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]

, 2016
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Richard Anthony, Steinmann, P. (Peter), Mieras, Liesbeth, Bratschi, M W, Jan Hendrik Richardus, Kasang, C. (Christa), Arielle Cavaliero, Mieras, L. (Liesbeth), Lee Reichman, Jacques van den Broek, Cavaliero, A. (Arielle), Christa Kasang, Yew, W.W. (Wing Wai), Anthony, R, van Brakel, Wim, Reichman, L, Emmanuelle Cambau, Anthony, Richard, Steinmann, Peter, Perera, G, Saunderson, P. (Paul), Saunderson, Paul, Cavaliero, Arielle, Saunderson, P, Richardus, Jan hendrik; id_orcid, Kasang, Christa, van den Broek, Jacques, Kasang, C, Richardus, J.H. (Jan Hendrik), Cavaliero, A, Cambau, E. (Emmanuelle), Peter Steinmann, Anthony, R. (Richard), Yew, W W, Reichman, L. (Lee), Mieras, L, Yew, Wing Wai, Perera, G. (Geethal), Richardus, Jan Hendrik, Wim van Brakel, Brakel, W.H. (Wim) van, Bratschi, M.W. (Martin W.), Paul Saunderson, van Brakel, W, Cambau, E, Reichman, Lee, van den Broek, J, Bratschi, Martin W., Steinmann, P, Cambau, Emmanuelle, Geethal Perera, Wing Wai Yew, van den Broek, J. (Jacques), Perera, Geethal, Liesbeth Mieras, Martin W. Bratschi   +55 more
core   +1 more source

Dose-response relationship between antimicrobial drugs and livestock-associated MRSA in pig farming.

Emerging infectious diseases, 2015
The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011-2013, an 18-month longitudinal study aimed at reducing the prevalence of LA-MRSA was conducted on 36 pig farms in the Netherlands.
Dorado-García, Alejandro, Dohmen, Wietske, Bos, Marian E H, Verstappen, Koen M, Houben, Manon, Wagenaar, Jaap A, Heederik, Dick J J   +6 more
openaire   +7 more sources

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source