Results 31 to 40 of about 440,820 (164)

Negative Symptoms in Schizophrenia: Exploring Glutamatergic Modulation Using a Computer-Based Quantitative Systems Pharmacology Approach

Frontiers in Pharmacology, 2014
Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts   +4 more
doaj   +1 more source

Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia

Archives of Academic Emergency Medicine, 2018
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population.
Hassan Barzegari, Arash Forouzan, Kambiz Masoumi, Hassan Motamed, Behzad Zohrevandi, Shima Zeynadini Meymand   +5 more
doaj   +1 more source

Giardicidal effect of black tea (camellia sinensis) in the treatment of giardia duodenalis in swiss mice

Revista Contexto & Saúde
This study evaluated the in vivo giardicidal potential of black tea (Camellia sinensis) in male Swiss mice experimentally infected with 104 cysts of Giardia duodenalis assemblage BIV.
Liara Izabela Lopes Romera, Cristiane Maria Colli, Amanda Gubert Alves dos Santos, Gessilda de Alcântara Nogueira de Melo, Ariana Ferrari, Mônica Lúcia Gomes   +5 more
doaj   +1 more source

Estimating the turnover time of high intravenous intake of vitamin C [PDF]

Archive of Oncology, 2011
Background: Intravenous dosing is generally recognized to be the only effective means of maintaining a high concentration of vitamin C in the plasma.
Wong Alfred
doaj   +1 more source

Two-compartment pharmacokinetic model of itraconazole after single oral dose administration - gender differences [PDF]

Vojnosanitetski Pregled
Background/Aim. Itraconazole (ICZ) is a widely used antifungal drug with hypervariable pharmacokinetics (PK), which is the result of the molecule’s nature itself, as well as the influence of multiple factors.
Miljković Milijana, Kovačević Aleksandra, Mikov Momir, Stanojković Tijana, Dragojević-Simić Viktorija   +4 more
doaj   +1 more source

Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development

Clinical and Translational Science, 2021
Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the dose ...
Kayla Ann Andrews, Joel S. Owen, James McCarthy, David Wesche, Nathalie Gobeau, Thaddeus H. Grasela, Jörg J. Möhrle   +6 more
doaj   +1 more source

Dose optimisation and scarce resource allocation: two sides of the same coin

BMJ Open, 2022
Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and ...
Govind Persad, Srinivas Murthy, William F Parker, Garth Strohbehn   +3 more
doaj   +1 more source

Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel

Heliyon, 2019
Tripterygium wilfordii Hook F. (TWHF) is a Chinese traditional medicine with cardiac toxicities. However, the mechanism of acute cardiac toxicity is not very clear.
Wei Zhao, Liping Xiao, Lanying Pan, Xianfu Ke, Yanting Zhang, Dian Zhong, Jianwei Xu, Fumin Cao, Liren Wu, Yuan Chen   +9 more
doaj   +1 more source

Deep sedation with midazolam and propofol in children undergoing ambulatory magnetic resonance imaging of the brain [PDF]

Vojnosanitetski Pregled, 2011
Backround/Aim. Sedation is necessary in children undergoing magnetic resonance imaging (MRI) to ensure motionless. The success of sedation is typically measured by two factors: safety (lack of adverse events) and effectiveness of the procedure ...
Jevđić Jasna, Šurbatović Maja, Drakulić-Miletić Svetlana, Žunić Filip   +3 more
doaj   +1 more source

Dose-Response Relationship between Antimicrobial Drugs and Livestock-Associated MRSA in Pig Farming1

Emerging Infectious Diseases, 2015
The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011-2013, an 18-month longitudinal study aimed at reducing the prevalence of LA-MRSA was conducted on 36 pig farms in the Netherlands.
Dorado-García, Alejandro, Dohmen, Wietske, Bos, Marian E H, Verstappen, Koen M, Houben, Manon, Wagenaar, Jaap A, Heederik, Dick J J   +6 more
openaire   +6 more sources