Results 11 to 20 of about 435,631 (309)

Dose-response relationship in phase I clinical trials: A European Drug Development Network (EDDN) collaboration study. [PDF]

Journal of Clinical Oncology, 2011
Abstract Introduction: Because a dose–response relationship is characteristic of conventional chemotherapy, this concept is widely used for the development of novel cytotoxic (CTX) drugs. However, the need to reach the MTD to obtain optimal benefit with molecularly targeted agents (MTA) is controversial.
Garcia VM, Olmos D, Gomez-Roca C, Cassier PA, Morales-Barrera R, Del Conte G, Gallerani E, Brunetto AT, Schoffski P, Marsoni S, Schellens JHM, Penel N, Voest E, Evans J, Plummer R, Wilson RH, Soria JC, Tabernero J, Verweij J, Kaye SB   +19 more
openaire   +9 more sources

Dose–response of an extrafine dry powder inhaler formulation of glycopyrronium bromide: randomized, double-blind, placebo-controlled, dose-ranging study (GlycoNEXT) [PDF]

International Journal of COPD, 2018
Kai M Beeh,1 Aida Emirova,2 Hélène Prunier,2 Debora Santoro,3 Marie Anna Nandeuil2 1Insaf Respiratory Research Institute, Wiesbaden, Germany; 2Global Clinical Development, Chiesi S.A.S, Bois-Colombes, France; 3Global Clinical Development ...
Beeh KM, Emirova A, Prunier H, Santoro D, Nandeuil MA   +4 more
doaj   +1 more source

The relationship between tacrolimus concentration-dose ratio and genetic polymorphism in patients subjected to renal transplantation [PDF]

Vojnosanitetski Pregled, 2018
Background/Aim. Tacrolimus concentration-dose ratio as a potential therapeutic drug monitoring strategy was suggested to be used for the patients subjected to renal transplantation.
Rančić Nemanja, Vavić Neven, Cikota-Aleksić Bojana, Magić Zvonko, Mikov Momir, Bokonjić Dubravko, Šegrt Zoran, Dragojević-Simić Viktorija   +7 more
doaj   +1 more source

Chronic inducible urticaria: confirmation through challenge tests and response to treatment

Einstein (São Paulo), 2020
Objective To evaluate the positivity of challenge tests of patients suspected of chronic inducible urticaria and the response to treatment. Methods A retrospective study of electronic medical records of patients suspected of chronic inducible ...
Amanda Rocha Firmino Pereira, Antônio Abílio Motta, Jorge Kalil, Rosana Câmara Agondi   +3 more
doaj   +2 more sources

Determination of the minimum effective volume of bupivacaine for ultrasound-guided infraclavicular brachial plexus block: a prospective, observer-blind, controlled study

Brazilian Journal of Anesthesiology, 2022
Background: We aimed to determine the minimum effective volume (MEV) of 0.5% bupivacaine for infraclavicular brachial plexus block. Methods: We assigned patients to volume groups consisting of five consecutive patients.
Semih Başkan, Çağıl Vural, Necati Alper Erdoğmuş, İsmail Aytaç   +3 more
doaj   +1 more source

Effective Dose Range of Intrathecal Isobaric Bupivacaine to Achieve T5–T10 Sensory Block Heights for Elderly and Overweight Patients: An Observational Study

Medicina, 2023
Background and Objectives: The dose selection for isobaric bupivacaine determines the success of spinal anesthesia (SA). A dose higher than the optimal dose causes high SA, whereas an underdose leads to inadequate spread of cephalad.
Ornwara Visavakul, Prangmalee Leurcharusmee, Tanyong Pipanmekaporn, Jiraporn Khorana, Jayanton Patumanond, Phichayut Phinyo   +5 more
doaj   +1 more source

Skipping a pillar does not make for strong foundations: Pharmacokinetic‐pharmacodynamic reasoning behind the shape of dose–response relationships in oncology

CPT: Pharmacometrics & Systems Pharmacology, 2023
Dose–response analysis is often applied to the quantification of drug‐effect especially for slowly responding disease end points where a comparison is made across dose levels after a particular period of treatment.
James W. T. Yates, Hitesh B. Mistry
doaj   +1 more source

Pharmacokinetic-Pharmacodynamic and Dose-Response Relationships of Antituberculosis Drugs: Recommendations and Standards for Industry and Academia [PDF]

Journal of Infectious Diseases, 2015
Antimicrobial pharmacokinetic-pharmacodynamic (PK/PD) science is vital to early antibiotic drug development to enable more efficient dose-effect study designs, identification of doses that may suppress drug resistance and choice of susceptibility breakpoints.
Gumbo, Tawanda, Angulo Barturen, Iñigo, Ferrer Bazaga, Santiago   +2 more
openaire   +3 more sources

Dose–response relationship between alcohol consumption and workplace absenteeism in Australia [PDF]

, 2023
Introduction: Workplace absenteeism is a burden in Australia. The estimated productivity losses due to alcohol were around $4.0 billion in 2017, with absenteeism driving 90% of these costs.
Livingston, Michael, Jiang, H., Jiang, H, Melvin Barrientos Marzan, Callinan, S, Michael Livingston, Heng Jiang, Marzan, M.B., Marzan, MB, Livingston, M, Sarah Callinan, Callinan, S.   +11 more
core   +1 more source

The dose-response relationship for memory impairment by anticholinergic drugs

Comprehensive Psychiatry, 1989
Twelve stabilized chronic schizophrenic outpatients receiving maintenance treatment with fluphenazine decanoate plus anticholinergic antiparkinsonian drugs underwent two challenge sessions receiving, in random sequence and double-blind, injections of either benztropine or glycopyrrolate (a peripherally active anticholinergic agent that penetrates the ...
J P, McEvoy, S, Freter
openaire   +2 more sources