Results 11 to 20 of about 757,481 (306)
The relationship between tacrolimus concentration-dose ratio and genetic polymorphism in patients subjected to renal transplantation [PDF]
Vojnosanitetski Pregled, 2018 Background/Aim. Tacrolimus concentration-dose ratio as a potential therapeutic drug monitoring strategy was suggested to be used for the patients subjected to renal transplantation.
Rančić Nemanja +7 more
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Chronic inducible urticaria: confirmation through challenge tests and response to treatment
Einstein (São Paulo), 2020 Objective To evaluate the positivity of challenge tests of patients suspected of chronic inducible urticaria and the response to treatment. Methods A retrospective study of electronic medical records of patients suspected of chronic inducible ...
Amanda Rocha Firmino Pereira +3 more
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Brazilian Journal of Anesthesiology, 2022 Background: We aimed to determine the minimum effective volume (MEV) of 0.5% bupivacaine for infraclavicular brachial plexus block. Methods: We assigned patients to volume groups consisting of five consecutive patients.
Semih Başkan +3 more
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CPT: Pharmacometrics & Systems Pharmacology, 2023 Dose–response analysis is often applied to the quantification of drug‐effect especially for slowly responding disease end points where a comparison is made across dose levels after a particular period of treatment.
James W. T. Yates, Hitesh B. Mistry
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Measurement and models accounting for cell death capture hidden variation in compound response. [PDF]
, 2020 Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including changes in cell growth, apoptosis, and
Bae, Song Yi +5 more
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Medicina, 2023 Background and Objectives: The dose selection for isobaric bupivacaine determines the success of spinal anesthesia (SA). A dose higher than the optimal dose causes high SA, whereas an underdose leads to inadequate spread of cephalad.
Ornwara Visavakul +5 more
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Model Selection versus Model Averaging in Dose Finding Studies [PDF]
, 2015 Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn +3 more
core +2 more sources
Cancer Biology & Medicine, 2010 OBJECTIVE To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. METHODS Human pancreatic carcinoma cell line MIA PaCa-2, was cultivated and divided into 5 groups: 0, 2, 5, 10, 17 ...
Ping WANG +3 more
doaj +1 more source
Dose-response relationship in phase I clinical trials: A European Drug Development Network (EDDN) collaboration study. [PDF]
Journal of Clinical Oncology, 2011 Abstract Introduction: Because a dose–response relationship is characteristic of conventional chemotherapy, this concept is widely used for the development of novel cytotoxic (CTX) drugs. However, the need to reach the MTD to obtain optimal benefit with molecularly targeted agents (MTA) is controversial.
Garcia VM +19 more
openaire +6 more sources
The dose-response relationship for memory impairment by anticholinergic drugs
Comprehensive Psychiatry, 1989 Twelve stabilized chronic schizophrenic outpatients receiving maintenance treatment with fluphenazine decanoate plus anticholinergic antiparkinsonian drugs underwent two challenge sessions receiving, in random sequence and double-blind, injections of either benztropine or glycopyrrolate (a peripherally active anticholinergic agent that penetrates the ...
J P, McEvoy, S, Freter
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