Results 41 to 50 of about 176,329 (291)

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu   +20 more
wiley   +1 more source

Effets d'un traitement chronique par la morphine sur le protéome des cellules de neuroblastome humain SH-SY5Y [PDF]

open access: yes, 2007
Afin de mieux comprendre les adaptations cellulaires induites suite à une prise chronique de morphine, une stratégie de type protéomique différentielle combinant les techniques d'électrophorèse et de spectrométrie de masse a été entreprise dans des ...
Mouledous, Lionel
core  

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

An investigation of the beliefs, attitudes and practice of health care workers towards the use of oral morphine in the palliative care management of HIV/AIDS and cancer patients in the Southern Region of Malawi [PDF]

open access: yes, 2008
[Background] Palliative care has been highlighted as an urgent need for patients with both HIV/AIDS and cancer in sub-Saharan Africa. Morphine is considered by the WHO as the drug of choice for severe pain in cancer.
Bates, Jane M
core   +1 more source

Morphine Induces Apoptosis of Human Endothelial Cells through Nitric Oxide and Reactive Oxygen Species Pathways

open access: yes, 2011
Morphine has been widely used for pain management. Other than analgesia, it has effects on vascular endothellial cells, including angiogenesis and apoptosis.
蕭柏妮;張明誠;鄭文芳;陳祈安;林漢威;謝長堯;孫維仁   +1 more
core   +1 more source

Acute and chronic effects of morphine on Low-Mg2+ ACSF-induced epileptiform activity during infancy in mice hippocampal slices

open access: yesResearch in Pharmaceutical Sciences, 2019
Interaction of morphine and seizure is complex. Mouse brain hippocampal slices were used to estimate how acute and chronic morphine treatment alters the low-magnesium artificial cerebrospinal fluid (LM-ACSF)-induced seizure activity.
Yousef Panahi   +6 more
doaj   +1 more source

Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

open access: yesFrontiers in Pharmacology, 2022
Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia.
Liqiong He   +12 more
doaj   +1 more source

Application of Morphine Anesthesia for Oral Surgery [PDF]

open access: yes, 2004
P(論文)Morphine anesthesia is often applied for the cardiovascular surgery and to patients complicated with cardiovascular disease because it has a property of hemodynamic stability due to the block from nociceptive stimulation and pain. However, there are
8772   +41 more
core  

The Distribution of opiates, cocaine and their metabolites in skeletal muscle tissue and vitreous humour as an aid to post-mortem toxicological interpretation. [PDF]

open access: yes
Post-mortem blood drug concentrations vary greatly and as a consequence of post-mortem change and redistribution may not reflect the concentration at the time of death.
Rees, Kelly-Ann
core   +7 more sources

Morphine Binds Creatine Kinase B and Inhibits Its Activity

open access: yesFrontiers in Cellular Neuroscience, 2018
Morphine is an analgesic alkaloid used to relieve severe pain, and irreversible binding of morphine to specific unknown proteins has been previously observed.
Ivan Weinsanto   +13 more
doaj   +1 more source

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