Results 41 to 50 of about 50,460 (257)

A Nine-Step Formal Synthesis of (±)-Morphine

, 2019
A nine-step stereoselective formal synthesis of (±)-morphine from readily available o-vanillin is presented. The carbocyclic structure of morphine was quickly assembled through an orchestration of the intermolecular Diels–Alder/Claisen/Friedel–Crafts ...
Louis Barriault, Amandine Xolin, Julie Brousseau, Amandine Xolin (6382523), Louis Barriault (1590244), Julie Brousseau (6382520)   +5 more
core   +1 more source

Cardiogenic shock induced by a high dose of intravenous morphine [PDF]

, 2021
Morphine is an opiate alkaloid characterized by various clinical effects, among which the most prominent are its analgesic and psychoactive effects. It also has a prominent depressive effect on the respiratory and cardiovascular system.
Sein Anand, Łukasz, Sein Anand, Jacek, Korolkiewicz, Paweł K., Paweł Konstanty Korolkiewicz, Jacek Sein Anand, Paweł Korolkiewicz, Łukasz Sein Anand   +6 more
core   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Acute and chronic effects of morphine on Low-Mg2+ ACSF-induced epileptiform activity during infancy in mice hippocampal slices

Research in Pharmaceutical Sciences, 2019
Interaction of morphine and seizure is complex. Mouse brain hippocampal slices were used to estimate how acute and chronic morphine treatment alters the low-magnesium artificial cerebrospinal fluid (LM-ACSF)-induced seizure activity.
Yousef Panahi, Ehsan Saboory, Shiva Roshan-Milani, Leila Drafshpoor, Yousef Rasmi, Ali Rassouli, Goudarz Sadeghi-Hashjin   +6 more
doaj   +1 more source

Morphine pre-exposure facilitates reinstatement but attenuates retention of morphine-induced place preference [PDF]

, 2010
BACKGROUND: Drug-associated conditioned stimuli are a key factor to induce morphine relapse. To date, limited evidence is available regarding the impact of drug history on propensity or vulnerability to relapse after long-term abstinence.
Yang, Xiaoyan, Sui, Nan, Zheng, Xigeng, Wang, Dongmei, Li, Yonghui   +4 more
core   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Synthesis of (−)-Morphine

, 2016
The preparation of the diastereomerically pure β-tetralone ketal 4 is reported. Intramolecular alkylidene C−H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15.
Arnold L. Rheingold (1274736), Douglass F. Taber (1568878), Timothy D. Neubert (1600189)   +2 more
core   +2 more sources

Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

Frontiers in Pharmacology, 2022
Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia.
Liqiong He, Liqiong He, Wei Xu, Chengliang Zhang, Chengliang Zhang, Zhuofeng Ding, Zhuofeng Ding, Qulian Guo, Qulian Guo, Wangyuan Zou, Wangyuan Zou, Jian Wang, Jian Wang   +12 more
doaj   +1 more source

Extended-release morphine sulfate in treatment of severe acute and chronic pain [PDF]

, 2010
Robert J Balch, Andrea TrescotDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA USAAbstract: Morphine is the archetypal opioid analgesic.
Robert J Balch, Andrea Trescot
core   +1 more source

An investigation of the beliefs, attitudes and practice of health care workers towards the use of oral morphine in the palliative care management of HIV/AIDS and cancer patients in the Southern Region of Malawi [PDF]

, 2008
[Background] Palliative care has been highlighted as an urgent need for patients with both HIV/AIDS and cancer in sub-Saharan Africa. Morphine is considered by the WHO as the drug of choice for severe pain in cancer.
Bates, Jane M
core   +1 more source