Results 41 to 50 of about 161,700 (313)

Acute and chronic effects of morphine on Low-Mg2+ ACSF-induced epileptiform activity during infancy in mice hippocampal slices

Research in Pharmaceutical Sciences, 2019
Interaction of morphine and seizure is complex. Mouse brain hippocampal slices were used to estimate how acute and chronic morphine treatment alters the low-magnesium artificial cerebrospinal fluid (LM-ACSF)-induced seizure activity.
Yousef Panahi, Ehsan Saboory, Shiva Roshan-Milani, Leila Drafshpoor, Yousef Rasmi, Ali Rassouli, Goudarz Sadeghi-Hashjin   +6 more
doaj   +1 more source

Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

Frontiers in Pharmacology, 2022
Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia.
Liqiong He, Liqiong He, Wei Xu, Chengliang Zhang, Chengliang Zhang, Zhuofeng Ding, Zhuofeng Ding, Qulian Guo, Qulian Guo, Wangyuan Zou, Wangyuan Zou, Jian Wang, Jian Wang   +12 more
doaj   +1 more source

Morphine Poisoning [PDF]

The Journal of Nervous and Mental Disease, 1919
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openaire   +2 more sources

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

The effect of cannabinoid type 2 receptor agonist on morphine tolerance

IBRO Neuroscience Reports
Pain highly impacts the quality of life of patients. Morphine is used for pain treatment; however, its side effects, especially morphine tolerance, limit its use in the clinic. The problem of morphine tolerance has plagued health workers and patients for
Di Cui, Yuanyuan Zhang, Mingyue Zhang
doaj   +1 more source

Morphine Binds Creatine Kinase B and Inhibits Its Activity

Frontiers in Cellular Neuroscience, 2018
Morphine is an analgesic alkaloid used to relieve severe pain, and irreversible binding of morphine to specific unknown proteins has been previously observed.
Ivan Weinsanto, Jinane Mouheiche, Alexis Laux-Biehlmann, Alexis Laux-Biehlmann, François Delalande, Arnaud Marquette, Virginie Chavant, Virginie Chavant, Florian Gabel, Sarah Cianferani, Alexandre Charlet, Marie-Odile Parat, Yannick Goumon, Yannick Goumon   +13 more
doaj   +1 more source

Effect of oxycodone vs. morphine as first‐line opioid on new persistent opioid use after orthopaedic surgery: A prospective sequential cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Postoperative opioids, intended for short‐term analgesia, contribute to new persistent opioid use in 1%–7% of patients, adversely affecting outcomes. Oxycodone may carry higher risk than morphine, though long‐term data are limited.
Eward J. Melis, Johanna E. Vriezekolk, Frédérique H. C. Bollen, Dirk E. Schrander, Arnt F. A. Schellekens, Bart J. F. van den Bemt   +5 more
wiley   +1 more source

A Nine-Step Formal Synthesis of (±)-Morphine

, 2019
A nine-step stereoselective formal synthesis of (±)-morphine from readily available o-vanillin is presented. The carbocyclic structure of morphine was quickly assembled through an orchestration of the intermolecular Diels–Alder/Claisen/Friedel–Crafts ...
Louis Barriault, Amandine Xolin, Julie Brousseau, Amandine Xolin (6382523), Louis Barriault (1590244), Julie Brousseau (6382520)   +5 more
core   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Morphine Antagonism

Journal of Pharmacy and Pharmacology, 1957
Abstract A series of compounds which antagonise the depressant activity of morphine in dogs is described. The most active compounds are the previously described 2:4-diamino-5-phenylthiazole and tetrahydro-5-aminoacridine. A mixture of both substances is more active than either alone.
F H, SHAW, S, GERSHON, G A, BENTLEY
openaire   +2 more sources