Results 51 to 60 of about 162,133 (313)
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source
Extended-release morphine sulfate in treatment of severe acute and chronic pain [PDF]
, 2010 Robert J Balch, Andrea TrescotDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA USAAbstract: Morphine is the archetypal opioid analgesic.
Robert J Balch, Andrea Trescot
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Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children
British Journal of Clinical Pharmacology, EarlyView.Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley +1 more source
Anti-CD40 antibody and toll-like receptor 3 ligand restore dendritic cell-mediated anti-tumor immunity suppressed by morphine [PDF]
, 2017 The influence of morphine on host immunity and the underlying mechanism are still unclear. In the current study, we investigated the influence of morphine on dendritic cells (DCs), its possible mechanism of action, and the molecules that could reverse ...
Chang, Ming-Cheng;Chen, Yu-Li;Chiang, Ying-Cheng;Cheng, Ya-Jung;Jen, Yu-Wei;Chen, Chi-An;Cheng, Wen-Fang;Sun, Wei-Zen +1 more
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Biotechnology and Bioengineering, EarlyView.ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian +4 more
wiley +1 more source
Basic and Clinical Neuroscience, 2011 Effects of intra-central amygdala administration of L-arginine, a nitric oxide precursor, and NG-nitro-L-arginine methyl-ester (L NAME), a nitric oxide synthase inhibitor, on the morphine-induced sensitization and also on the expression of morphine ...
Hedayat Sahraei +7 more
doaj +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Is the combination of morphine with ketamine better than morphine alone for postoperative intravenous patient-controlled analgesia? [PDF]
, 2008 BACKGROUND: The addition of ketamine to morphine for patient-controlled analgesia (PCA) is supported by previous basic and clinical research, but has been challenged by subsequent negative studies.
Eichenberger, Urs +5 more
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فصلنامه دانشگاه علوم پزشکی جهرم, 2013 The most important side effect of addictive drugs is their interaction with nervous system so that soon after taking the drug, the neurons̉ connections in nervous system are addicted to receiving the drugs frequently. The aim of this study was the effect
Eebrahim Hosseini +4 more
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