Differential Changes in Expression of Stress- and Metabolic-Related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal. [PDF]
PLoS ONE, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Bernadett Pintér-Kübler +6 more
doaj +4 more sources
Sensitization to morphine withdrawal in guinea-pigs
European Journal of Pharmacology, 2005 The aim of this study was to determine whether sensitization occurred to morphine withdrawal. Guinea-pigs were treated twice daily with increasing doses of morphine (10-100 mg/kg s.c.) for 3 days followed by injection of morphine 100 mg/kg on the fourth day.
Mizutani, Akiko +2 more
openaire +4 more sources
Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.
PLoS ONE, 2011 A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor +3 more
doaj +2 more sources
The (–)-Borneol Effect on Addiction/Abstinence by Morphine in Mice
Drugs and Drug Candidates, 2023 Opioids such as morphine are the first choice in acute and chronic pain treatment. However, they lead to addiction. Several studies have searched (i) to find a molecule that can replace morphine use or (ii) to reduce its adverse effects.
Maurício Pires de Moura do Amaral +8 more
doaj +1 more source
Effects of aging on morphine withdrawal in the rat
Experimental Gerontology, 1994 Little is known about the effects of aging on the process of opiate dependence and withdrawal in the rat. The present study was undertaken to quantitate naloxone-precipitated opiate withdrawal in young (3-4 months old) and aged (24 month old) Long-Evan female rats.
Department of Pharmacodynamics and The Center for the Neurobiology of Aging, University of Florida, Gainesville, Florida 32610, USA ( host institution ) +1 more
openaire +3 more sources
The Effects of Hydroalcoholic Extract of Satureja khuzestanica on Naloxone-Induced Morphine Withdrawal Symptoms in Wistar Rats [PDF]
International Journal of Basic Science in Medicine, 2020 Introduction: The inflammatory system, oxidative stress, and cholinergic pathways are some important factors in long-term opioid dependence withdrawal.
Bahareh Ebrahimi, Saeed Esmaeili-Mahani
doaj +1 more source
The Effect of Resistance Training on Some Markers of Apoptosis Caused by Diabetic Cardiomyopathy and Morphine withdrawal Syndrome in Diabetic Male Rats [PDF]
مجله دانشگاه علوم پزشکی جیرفت, 2023 Introduction: Morphine withdrawal syndrome is one of the aggravating factors of apoptosis in diabetic cardiomyopathy. The purpose of this research was to investigate the effect of resistance training on some markers of apoptosis caused by diabetic ...
Maryam Sadegh Joola +2 more
doaj
Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome [PDF]
Brazilian Journal of Pharmaceutical SciencesDrug addiction is one of the most important global problems. Medicinal herbs have been traditionally used in the management and treatment of opioid withdrawal syndrome and pain. The aim of this study was to determine the effect of A.
Zahra Lorigooini +4 more
doaj +1 more source
Journal of Research in Medical Sciences, 2004 Background: There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of Morphine dependence. Objective: To investigate the acute and long-term effects of Verapamil in Morphine dependent mice.
M Rabbani, A Jafarian, M Sobhanian
doaj
Evaluation of the Effects of Chronic Administration of Citrus aurantium Essential Oil on the Development of Tolerance and Dependence to Morphine [PDF]
Pharmaceutical Sciences, 2019 Background: Long-term exposure to opioids may lead to physical dependence and tolerance. The purpose of this study was to investigate the effects of Citrus aurantium essential oil (CEO) on the morphine-induced tolerance and dependence.
Alireza Parvizpur +4 more
doaj +1 more source