The gut microbiome contributes to somatic morphine withdrawal behavior and implicates a TLR2 mediated mechanism [PDF]
Gut Microbes, 2023 The ongoing opioid epidemic has left millions of people suffering from opioid use disorder due to the over-prescription of highly addictive substances.
Bridget Truitt +6 more
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AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal [PDF]
iScience, 2023 Summary: Dopamine D1 receptor-expressing medium spiny neurons (D1R-MSNs) and dopamine D2 receptor-expressing MSNs (D2R-MSNs) in nucleus accumbens (NAc) have been demonstrated to show different effects on reward and memory of abstinence.
Xiaohui Bai +10 more
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Linagliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor, Reduces Physical and Behavioral Effects of Morphine Withdrawal [PDF]
Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
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Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]
Reviews in Clinical Medicine, 2015 Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar +5 more
doaj +3 more sources
Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats [PDF]
Pharmaceutical Sciences Asia, 2022 Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia ...
Priscilla Kolibea Mante +7 more
doaj +1 more source
The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2023 Background and Aim: Serotonergic system has a role in morphine dependence and withdrawal symptoms via its receptors. On the other hand, the effect of 5-HT2A receptor on withdrawal symptoms has not been evaluated completely.
Nasrin Hashemi-Firouzi +4 more
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Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal. [PDF]
PLoS ONE, 2012 Both the hypothalamus-pituitary-adrenal (HPA) axis and the extrahypothalamic brain stress system are key elements of the neural circuitry that regulates the negative states during abstinence from chronic drug exposure.
M Luisa Laorden +7 more
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Cell Reports, 2021 Summary: Previous work has shown that the paraventricular nucleus of the thalamus (PVT) is an important region that is involved in the conditioned context-induced retrieval of morphine withdrawal memory.
Lanfang Yu +9 more
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Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal. [PDF]
PLoS ONE, 2012 Experimental and clinical findings have shown that administration of adrenoceptor antagonists alleviated different aspects of drug withdrawal and dependence. The present study tested the hypothesis that changes in CREB activation and phosphorylated TORC1
Fátima Martín +5 more
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Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice
Substance Abuse: Research and Treatment, 2010 The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth +4 more
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