Results 41 to 50 of about 55,011 (233)

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

The Effects of Hydroalcoholic Extract of Satureja khuzestanica on Naloxone-Induced Morphine Withdrawal Symptoms in Wistar Rats [PDF]

International Journal of Basic Science in Medicine, 2020
Introduction: The inflammatory system, oxidative stress, and cholinergic pathways are some important factors in long-term opioid dependence withdrawal.
Bahareh Ebrahimi, Saeed Esmaeili-Mahani
doaj   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo, Sarah N. Hilmer, David J. Hunter, Stephanie Mathieson, Riyaas Mohamed, Leo Li, Natalie Fung, Anthony Yue, Manuela L. Ferreira   +8 more
wiley   +1 more source

Mitragynine attenuates withdrawal syndrome in morphine-withdrawn zebrafish.

PLoS ONE, 2011
A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to ...
Beng-Siang Khor, Mohd Fadzly Amar Jamil, Mohamad Ilham Adenan, Alexander Chong Shu-Chien   +3 more
doaj   +1 more source

The Effect of Resistance Training on Some Markers of Apoptosis Caused by Diabetic Cardiomyopathy and Morphine withdrawal Syndrome in Diabetic Male Rats [PDF]

مجله دانشگاه علوم پزشکی جیرفت, 2023
Introduction: Morphine withdrawal syndrome is one of the aggravating factors of apoptosis in diabetic cardiomyopathy. The purpose of this research was to investigate the effect of resistance training on some markers of apoptosis caused by diabetic ...
Maryam Sadegh Joola, Abbas Saremi, Mojtaba Khansooz   +2 more
doaj  

Dopamine D4 receptor counteracts morphine-induced changes in M opioid receptor signaling in the striosomes of the rat caudate putamen. [PDF]

, 2015
Morphine is one of the most potent analgesic drugs used to relieve moderate to severe pain. After long-term use of morphine, neuroadaptive changes in the brain promotes tolerance, which result in a reduced sensitivity to most of its effects with ...
De-la-Calle-Martin, Adelaida, Medina-Luque, José, Rivera-Ramirez, Alicia, Roales-Buján, Ruth, Shumilov, Kirill, Suárez-Boomgaard, Diana, Valderrama-Carvajal, Alejandra   +6 more
core  

Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome [PDF]

, 2017
No abstract ...
Allocco, Bier, Desai, Dryden, Gibson, Hodgson, Jones, Kocherlakota, Liu, Mactier, Maeda, McGlone, McGlone, Noormohammadi, Steinhorn, Yuan   +15 more
core   +1 more source

Hofmann Degradation of Asparagine and Glutamine as an Efficient Approach for the Synthesis of Derivatized Lysine Homologs

European Journal of Organic Chemistry, EarlyView.
A practical and scalable route to C1 and C2 lysine homologs has been developed using Hofmann degradation of N‐protected L‐asparagine and L‐glutamine as the key step. These short‐tether scaffolds enable efficient synthesis of diverse Fmoc‐protected noncanonical amino acids (ncAAs) bearing donor, acceptor, redox‐active, and fluorescent residues.
Adelaide R. Mashweu, François J. De Beer, Jolien Bertouille, Steven Ballet, Charlotte Martin, Ulrich Hennecke, Charlene Marais, Vladimir A. Azov   +7 more
wiley   +1 more source