Results 51 to 60 of about 55,011 (233)

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]

, 2017
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R, Copits, Bryan A, Gereau, Robert W, IV, Gomez, Adrian M, Grajales-Reyes, Jose G, O\u27Brien, Daniel E, Samineni, Vijay K, Trigg, Sarah L   +7 more
core   +2 more sources

Things We Do for No Reason™: Withholding opioids among patients with acute pain and opioid use disorder

Journal of Hospital Medicine, EarlyView.
Abstract Hospitalists care for patients with acute pain who have an opioid use disorder and require pain management. Hospitalists may withhold opioids for acute pain due to a variety of reasons. However, adequate pain management in patients with opioid use disorder, including with opioids, is the standard of care. This piece explains how to best manage
Anna‐Maria South, Susan L. Calcaterra, Marlene Martin   +2 more
wiley   +1 more source

Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: Implications for the study of the affective properties of drugs of abuse [PDF]

, 2013
Several studies suggest that 50-kHz ultrasonic vocalizations (USVs) may indicate a positive affective state in rats, and these vocalizations are increasingly being used to investigate the properties of psychoactive drugs.
FRAU L, MORELLI M, PLUMITALLO A, SIMOLA N   +3 more
core   +1 more source

Comparing leukocyte‐ and thrombocyte‐rich fibrin and autologous grafts for the treatment of experimentally induced wounds in the tarsometatarsus of chickens

Veterinary Record, EarlyView.
Abstract Background Managing open wounds in birds is challenging. This study compared leukocyte‐ and thrombocyte‐rich fibrin (L‐TRF) and autologous grafts for treating wounds in the tarsometatarsus of chickens. Methods Full‐thickness wounds were experimentally induced in the tarsometatarsus of 23 healthy adult chickens.
Vivian Ferreira Rech, Sheila Canevese Rahal, Renata Dalcol Mazaro, Luna Scarpari Rolim, Guilherme Rech Cassanego, Matheus Yuri Dos Santos, Rafael Almeida Fighera   +6 more
wiley   +1 more source

Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome [PDF]

Brazilian Journal of Pharmaceutical Sciences
Drug addiction is one of the most important global problems. Medicinal herbs have been traditionally used in the management and treatment of opioid withdrawal syndrome and pain. The aim of this study was to determine the effect of A.
Zahra Lorigooini, Fatemeh Heibati, Seyyed Matin Ahmadi, Sareh Mohammadi, Mahmoud Rafieian-Kopaei   +4 more
doaj   +1 more source

The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice. [PDF]

, 2014
The main challenge in treating opioid addicts is to maintain abstinence due to the affective consequences associated with withdrawal which may trigger relapse.
A Bailey, A Szeto, Alexis Bailey, C Goeldner, CL Kovacs, CS Carter, DL Muller, DS Carson, E Peles, EA Phelps, EB Keverne, EV Nunes, G Domes, G Gimpl, G Koob, GF Koob, GF Koob, GL Kovacs, GL Kovacs, GL Kovacs, GL Kovacs, GM Singewald, I Christensson-Nylander, Ian Kitchen, ID Neumann, IS McGregor, IS McGregor, J Qi, J Qi, J Wang, JC Veilleux, JCJ Liu, JH Broadbear, JH Jaffe, JR Mantsch, L Stinus, M Heinrichs, M Heinrichs, M Le Moal, M Lukas, M Lukas, ND Volkow, P Zanos, Panos Zanos, Polymnia Georgiou, PR Lee, Raphaëlle Winsky-Sommerer, RJ Windle, RM Craft, S Chaviaras, S Dawe, S Erb, S Erb, S Erb, SC Heinrichs, Sherie R Wright, Susanna M Hourani, T Anraku, T Engstrom, VA Redila, WR Martin, Y Zhou, Z Sarnyai, Z Sarnyai, ZD You   +64 more
core   +1 more source

Determinants of Compliance to Enhanced Recovery Protocol After Emergency Laparotomy

World Journal of Surgery, EarlyView.
Enhanced Recovery protocols (ERP) are comprehensive, evidence‐based approaches aimed at accelerating patient recovery and improving surgical results; increasing evidence exists about their adoption in emergency laparotomy. The study aimed to evaluate the compliance to the proposed postoperative pathway and the determinants of late recovery.
Marco Ceresoli, Chiara Fumagalli, Alan Biloslavo, Antonio La Greca, Michele Carlucci, Giovanni Pesenti, Savino Occhionorelli, Pietro Bisagni, Carlo Feo, Dario Tartaglia, Dario Parini, Matteo Runfola, Riccardo Somigli, Diego Visconti, Diego Mariani, Diletta Cassini, Andrea Mingoli, Marco Braga, On behalf of the Study Collaborative Group   +18 more
wiley   +1 more source

Episodic Withdrawal Promotes Psychomotor Sensitization to Morphine [PDF]

Neuropsychopharmacology, 2010
The relative intermittency or continuity of drug delivery is a major determinant of addictive liability, and also influences the impact of drug exposure on brain function and behavior. Events that occur during the offset of drug action (ie, acute withdrawal) may have an important role in the consequences of intermittent drug exposure.
Patrick E, Rothwell, Jonathan C, Gewirtz, Mark J, Thomas   +2 more
openaire   +2 more sources

Prenatal Prescription Opioid Analgesic Exposure and Academic Performance in Third Grade Children: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the association between prenatal exposure to opioids analgesics and academic performance in third grade children. Design Population‐based cohort study using linked data from New South Wales birth records, medicine dispensing data, and national standardised test results.
Bianca Varney, Helga Zoega, Malcolm B. Gillies, Claudia Bruno, Alys Havard, Antonia Shand, Natasha Nassar, Jonathan Brett   +7 more
wiley   +1 more source

Comparison between Acute and Long-Term Effects of Verapamil on Naloxane Induced Morphine Withdrawal in Mice

Journal of Research in Medical Sciences, 2004
Background: There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of Morphine dependence. Objective: To investigate the acute and long-term effects of Verapamil in Morphine dependent mice.
M Rabbani, A Jafarian, M Sobhanian
doaj